242 research outputs found
L'assordante silenzio nero e le ostentate rivendicazioni rosse: gli antitetici modelli comunicativi dei due terrorismi italiani
No full textThe author introduces a comparative examination among the antithetical communicative expressions of the two terrorist experiences, appeared in the second Italian postwar period: the "black carnages" and the "red paramilitary attacks". Starting from their inverse correlation among the "meaning" and the "meant" of the terrorist "sign", the author reconstruct the opposite languages communicated by these different typologies of attempts
Tampa Natives Show: Guest, Paul Guzzo, Author & \u3ci\u3eTribune\u3c/i\u3e History Writer, January 9, 2014
No full textYou\u27ll enjoy this great show with special guest, Paul Guzzo. Paul is an Author and history writer for the Tampa Tribune. Watch as Paul shares how he became involved in his search of Tampa\u27s past! He recently wrote and article about the Tampa Natives Show, which was published on January 1st, 2014
Un’analisi delle relazioni tra la struttura finanziaria e il costo del capitale nelle aziende del distretto cartario lucchese. Alcune evidenze empiriche
No full textLa creazione di valore economico, come noto, è condizione per la sopravvivenza e lo sviluppo delle unità aziendali operanti nei diversi contesti economici. Lo studio dell’attitudine delle aziende a creare valore presuppone l’osservazione della redditività e del costo delle fonti di finanziamento. Ragionando secondo la logica del coeteris paribus, appare evidente come il valore creato da qualsiasi unità produttiva cresca al diminuire del costo del capitale investito. Il costo del capitale, peraltro, è una grandezza che risulta influenzata dall’agire composito di alcune variabili, tra cui, in primis, quelle riferibili al rischio operativo e finanziario. A parità di rendimento del capitale, dunque, i suddetti rischi costituiscono le principali leve (driver) su cui agire allo scopo di contenere il costo del capitale e, quindi, di massimizzare il valore dell’azienda.
Il presente lavoro si basa sull’analisi del secondo driver di valore citato, ossia il rischio finanziario. Con esclusivo riferimento all’aspetto sopra delineato, la ricerca mira ad individuare gli effetti della politica finanziaria sul costo del capitale. A tale scopo, è stata condotta un’indagine empirica su un campione di aziende appartenenti al distretto cartario lucchese (cartiere e cartotecniche, che operano per la realizzazione di carta tissue) con riguardo ai periodi amministrativi del triennio 2004-2006. Dai bilanci riclassificati e dalle informazioni acquisite, sottoponendo specifici questionari alle aziende campionate, sono state determinate le variabili necessarie per la stima del costo medio ponderato del capitale, ottenuto, per quanto attiene al costo del capitale proprio, mediante l’impiego del Capital Asset Pricing Model (CAPM).
I risultati della ricerca sono stati utilizzati per osservare le variazioni sia del costo delle singole fonti di finanziamento (capitale proprio e capitale di debito) sia del rapporto tra ciascuna delle suddette fonti di finanziamento e il capitale investito, al variare del rapporto di leverage. In termini più generali, dunque, l’indagine condotta mira a delineare alcune conclusioni relative alla variabilità del costo medio ponderato del capitale (nel linguaggio anglosassone WACC) in relazione al mutamento della struttura finanziaria
Plant Derived Natural Products against Pseudomonas aeruginosa and Staphylococcus aureus: Antibiofilm Activity and Molecular Mechanisms
No full textBacteria are social organisms able to build complex structures, such as biofilms, that are highly organized surface-associated communities of microorganisms, encased within a self- produced extracellular matrix. Biofilm is commonly associated with many health problems since its formation increases resistance to antibiotics and antimicrobial agents, as in the case of Pseudomonas aeruginosa and Staphylococcus aureus, two human pathogens causing major concern. P. aeruginosa is responsible for severe nosocomial infections, the most frequent of which is ventilator-associated pneumonia, while S. aureus causes several problems, like skin infections, septic arthritis, and endocarditis, to name just a few. Literature data suggest that natural products from plants, bacteria, fungi, and marine organisms have proven to be effective as anti-biofilm agents, inhibiting the formation of the polymer matrix, suppressing cell adhesion and attachment, and decreasing the virulence factors’ production, thereby blocking the quorum sensing network. Here, we focus on plant derived chemicals, and provide an updated literature review on the anti-biofilm properties of terpenes, flavonoids, alkaloids, and phenolic compounds. Moreover, whenever information is available, we also report the mechanisms of actio
Phytochemical Investigation of Myrcianthes cisplatensis: Structural Characterization of New p-Coumaroyl Alkylphloroglucinols and Antimicrobial Evaluation Against Staphylococcus aureus
No full textSpecies of Myrtaceae Juss., the ninth largest family of flowering plants, are a valuable source of bioactive specialized metabolites. A leading position belongs to phloroglucinol derivatives, thanks to their unusual structural features and biological and pharmacological properties. Myrcianthes cisplatensis (Cambess.) O. Berg, a common tree on the banks of rivers and streams of Uruguay, southern Brazil, and northern Argentina, with aromatic leaves, is known as a diuretic, febrifuge, tonic, and good remedy for lung and bronchial diseases. Despite knowledge about traditional use, few data on its phytochemical properties have been reported in the literature. The methanol extract of M. cisplatensis, grown in Arizona, USA, was first partitioned between dichloromethane and water and then with ethyl acetate. The enriched fractions were evaluated using a broth microdilution assay against Staphylococcus aureus ATCC 29213 and 43300 (methicillin-resistant S. aureus (MRSA)). The potential antimicrobial activity seemed to increase in the dichloromethane extract, with a MIC value of 16 μg/mL against both strains. Following a bio-guided approach, chromatographic techniques allowed for isolating three coumarin derivatives, namely endoperoxide G3, catechin, and quercitrin, and four new p-coumaroyl alkylphloroglucinol glucosides, named p-coumaroylmyrciacommulone A-D. Their structures were characterized through spectroscopic techniques: 2D-NMR experiments (HSQC, HMBC, and HSQC-TOCSY) and spectrometric analyses (HR-MS). The antimicrobial assessment of pure compounds against S. aureus ATCC 29213 and ATCC 43300 demonstrated the best activity for p-coumaroylmyrciacommulone C and D with the growth inhibition of 50% at 32 μg/mL against both strains of S. aureus
Genetic Analysis of Growth in Performance Tested Young Bulls accounting for Indirect Genetic Effects.
No full textL’amministrazione dei beni degli enti ecclesiastici, tra diritto canonico e diritto dello Stato
No full textIn this article the author examines the normative discipline of the Ecclesiastical Bodies’ administration, between Canon law and Italian law. The subject is included in the perspective of Pope Francis’ reform, also as a deontological issue
Scelte tragiche. Criteri per il “Triage” dei pazienti Covid-19 che hanno bisogno di terapia intensiva
No full textIn the present paper, the Author stresses the point that far from being a state of emergency where law and legal principles are suspended, Triage is a legal question to be faced with formal criteria. Every form of consequentialist thinking adopting different kind of material criteria, such those embraced in the guidelines drawn up by national medical societies in order to manage the pandemic, by necessarily involving a discrimination against fragile patients is incompatible with the basic principle of fundamental equality of human lives. The Author particularly focuses on the German case, where for its special constitutional tradition this basic principle is strongly avowed
Metabolomic Profiling and Antioxidant Activity of Fruits Representing Diverse Apple and Pear Cultivars
Get PDFThe false fruits of apple (Malus domestica) and pear (Pyrus communis) are consumed all over the world, contributing to the dietary intake of health-promoting antioxidant phytochemicals. For example, polyphenols confer many beneficial effects (according to their chemical structure, bioavailability, and absorption efficiency in the gut) and the consumption of polyphenol-rich apple and pear fruits may therefore reduce the risk of some diseases. However, the content of such molecules is highly dependent on the specific fruit cultivar. To examine this metabolic diversity in detail, we used metabolomic analysis (NMR and HPLC-DAD/MS) to profile the metabolome of six apple and five pear cultivars. We also determined the antioxidant capacity of the extracts (FRAP assay) and correlated this with the metabolomic composition and abundance of specific metabolites. We observed the cultivar-specific accumulation of sugars, amino acids, malic acid, and various polyphenols, which was also related to the growing season for some cultivars. We found that the ancient Italian apple Pom Prussian was enriched for chlorogenic acid as well as more characteristic polyphenols (phloretin derivatives), the pear cultivar Abate Fetel was low in sucrose, and both cultivars displayed high in vitro antioxidant activity. These cultivars may, therefore, be particularly attractive to health-conscious consumers
- …
