6 research outputs found
Cardiovascular involvement in children with COVID-19 temporally related multisystem inflammatory syndrome (MIS-C): can cardiac magnetic resonance arrive to the heart of the problem?
Background: Multisystem inflammatory syndrome in children (MIS-C) shows a significant overlap of symptoms with other hyper-inflammatory diseases such as Kawasaki disease (KD), but the real difference of the two conditions is still matter of debate. Coronary artery lesions (CAL) are the most relevant complication in KD. Nonetheless, CAL, myocarditis, pericarditis, arrhythmia are the main cardiovascular complications in MIS-C. A close clinical assessment is mandatory, both at the diagnosis and during the follow-up, by ECG and echocardiography. Cardiac magnetic resonance (MRI) adds important data to ultrasound findings. However, cardiac MRI studies in MIS-C are limited to a small number of cohorts. Methods: We enrolled 20 children (age:1-16 years; 11 F; 9 M) with cardiac involvement secondary to MIS-C, all evaluated by cardiac MRI. Results: 8 children showed pathological cardiac MRI: 2 showed pericardial effusion; 2 showed myocardial oedema; 1 showed aortic insufficiency; 3 showed delayed enhancement (one for acute myocarditis with oedema; 2 for myocardial fibrosis). Delayed enhancement was reduced significantly 5.6-9 months after the first MRI evaluation. 25% of patients with pathological MRI had CAL associated with valvular insufficiency of 2 valves. 17% of patients with normal MRI had CAL, associated with valvular insufficiency of 1 valve in 1 patient. The correlations between haematological, clinical, cardiologic parameters, treatment, did not reach the statistical significance. 4 patients were treated with anakinra. Among those, 2 patients showed a normal cardiac MRI. Cardiac lesions resolved in all the patients during the follow-up. Some patients with pathological cardiac MRI could not underwent a control with MRI, for the low compliance. However, echocardiography and ECG, documented the resolution of the pathological data in these cases. Conclusions: A higher risk of CAL was documented in patients with an association of other cardiac lesions. Cardiac MRI is difficult to perform routinely; however, it is useful for evaluating the acute myocardial damage and the outcome of patients with MIS-C
La MIS-C fra presente e futuro: cardio-RMN e prognosi cardiologica a medio e lungo termine. Esperienza di un singolo centro.
Optimization of perovskite/c-Si tandem module for energy yield maximization under real-world conditions
Tandem technology has emerged as one of the most promising innovations in the field of photovoltaics. Higher conversion efficiencies than standard single-junction cells have already been achieved. Proving how these laboratory conversion capabilities translate into real-world performance is therefore a main interest drive within the photovoltaic research community.Typically, photovoltaic device performance is assessed in Standard Test Conditions (STC). For the majority of climates, this is however not representative of actual operating conditions. With the aim of studying potential system applications, the energy yield prediction method adopted in this thesis analyzes tandem technology performance considering real-world conditions. For this scope, the PVMD Toolbox for PV system modeling is employed.The tandem device investigated in this work is a perovskite/c-Si based structure in a two-terminal architecture. In particular, a TU Delft own poly-SiOx based crystalline silicon bottom cell is utilized in the configuration. This structure is implemented in the Toolbox to carry out Optical simulations from cell to module system level. Operating conditions are introduced through use of the Toolbox Weather and Thermal models. These recreate real-world illumination and climate settings for the selected locations of Reykjavik, Rome and Alice Springs. With an STC-optimized perovskite thickness of 515 nm, the hourly implied photocurrent density of the device is calculated and validated. The jph annual average is 1.92, 3.34 and 5.01 mA/cm2 for the three locations, respectively. These values take into account a sub-cells current mis-match loss between 5 and 8% depending on location. To reproduce real-world cell electrical parameters behavior, the variable irradiance and temperature sub-cells J-V curves have been obtained. A poly-SiOx based silicon prototype was tested in laboratory settings and its curves then utilized in simulations after measurements validation.The module annual energy yield is computed through simulations with the Toolbox Electric model. In terms of specific DC yield, the STC-optimized module delivers 820, 1,427 and 2,161 kWh/kWp/year in the three locations. The power mismatch lowering effect due to the fill factor gain compensates the current mismatch in this 2T configuration, reducing energy mismatch losses. This performance is then compared to a reference single-junction poly-SiOx based silicon module, to show how tandem technology potentially outperforms standard modules differently depending on climatic conditions. The tandem module is also assessed in terms of DC performance ratio (PR), exhibiting values over 0.94 for all three locations. The structure is then real-world optimized by varying perovskite thickness, with the goal of maximizinglocation-specific energy yield and PR. Slight improvements are obtained for the Reykjavik and Alice Springs locations, where the energy yield increases by few relative percentage points along with PR.Electrical Engineering | Sustainable Energy Technolog
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Peritoneal dialysis‐related hydrothorax: A conservative approach should be the best beginning option
Thoracic imaging of coronavirus disease 2019 (COVID-19) in children: a series of 91 cases
Background: Pulmonary infection with SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2; COVID-19) has rapidly spread worldwide to become a global pandemic. Objective: To collect paediatric COVID-19 cases worldwide and to summarize both clinical and imaging findings in children who tested positive on polymerase chain reaction testing for SARS-CoV-2. Materials and methods: Data were collected by completion of a standardised case report form submitted to the office of the European Society of Paediatric Radiology from March 12 to April 8, 2020. Chest imaging findings in children younger than 18 years old who tested positive on polymerase chain reaction testing for SARS-CoV-2 were included. Representative imaging studies were evaluated by multiple senior paediatric radiologists from this group with expertise in paediatric chest imaging. Results: Ninety-one children were included (49 males; median age: 6.1 years, interquartile range: 1.0 to 13.0 years, range: 9 days–17 years). Most had mild symptoms, mostly fever and cough, and one-third had coexisting medical conditions. Eleven percent of children presented with severe symptoms and required intensive unit care. Chest radiographs were available in 89% of patients and 10% of them were normal. Abnormal chest radiographs showed mainly perihilar bronchial wall thickening (58%) and/or airspace consolidation (35%). Computed tomography (CT) scans were available in 26% of cases, with the most common abnormality being ground glass opacities (88%) and/or airspace consolidation (58%). Tree in bud opacities were seen in 6 of 24 CTs (25%). Lung ultrasound and chest magnetic resonance imaging were rarely utilized. Conclusion: It seems unnecessary to perform chest imaging in children to diagnose COVID-19. Chest radiography can be used in symptomatic children to assess airway infection or pneumonia. CT should be reserved for when there is clinical concern to assess for possible complications, especially in children with coexisting medical conditions
