75 research outputs found

    Cristiani evangelici nella polis: il contributo metodista al Patto di integrazione e alle intese

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    Il contributo presenta i risultati di una ricerca volta a comprendere l’idea di unità e di integrazione emersa all’interno del metodismo italiano in epoca repubblicana, al fine di individuare lo spazio pubblico nel quale esso ha ambito a collocarsi e delineare lo specifico contributo metodista al dibattito sulle intese con lo Stato. L’analisi si concentra principalmente sulla teologia politica che Sergio Aquilante, Franco Becchino e Giorgio Spini posero prima alla base del progetto di integrazione con la chiesa valdese e di federazione delle chiese evangeliche italiane e poi nella scelta della strada per l’intesa

    Né vicino né distante

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    In the first phase of the COVID-19 pandemic, the scientific community has tried to place itself in a “post-pandemic” perspective, seeking the “new at all costs”. But it is difficult reasoning in a “post-Covid” key, both due to the obvious contradiction of doing so while the health crisis was still ongoing, and because the critical distance from the present had not yet matured. Faced with the effort of the project sciences to demonstrate the ability to ‘project’, that is, to be able to manage prospects for the future, this reflection intends to formulate -at the same time- critical and proactive reasoning that starts from the extraordinary experience underway to reconstruct the conditions of the public space. The health issue has heavily invested the public space, which in turn has become problematic, strongly requiring elements of innovation from the project to guarantee safety in the situations of presence, reinventing the conditions of proximity, directing action to define new geometric and proxemics logics. In the direction to find different questions from the one that asks “what is the good distance from the other?”, the author thinks it is good to start a reflection about the new way experienced during the pandemic, finally finding the conditions in which we can stay together again

    Refractory IgA Nephropathy: A Challenge for Future Nephrologists

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    IgA nephropathy (IgAN) represents the most prevalent form of primary glomerulonephritis, and, on a global scale, it ranks among the leading culprits behind end-stage kidney disease (ESKD). Presently, the primary strategy for managing IgAN revolves around optimizing blood pressure and mitigating proteinuria. This is achieved through the utilization of renin–angiotensin system (RAS) inhibitors, namely, angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). As outlined by the KDIGO guidelines, individuals who continue to show a persistent high risk of progressive ESKD, even with comprehensive supportive care, are candidates for glucocorticoid therapy. Despite these therapies, some patients have a disease refractory to treatment, defined as individuals that present a 24 h urinary protein persistently >1 g after at least two rounds of regular steroids (methylprednisolone or prednisone) and/or immunosuppressant therapy (e.g., mycophenolate mofetil), or who do not tolerate regular steroids and/or immunosuppressant therapy. The aim of this Systematic Review is to revise the current literature, using the biomedical database PubMed, to investigate possible therapeutic strategies, including SGLT2 inhibitors, endothelin receptor blockers, targeted-release budesonide, B cell proliferation and differentiation inhibitors, fecal microbiota transplantation, as well as blockade of complement components

    Tutor’s Role in WhatsApp Learning Groups: A Quali-Quantitative Methodological Approach

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    In recent years, digital tools, such as WhatsApp, have been increasingly deployed to support group interaction and collaboration in higher education contexts. To understand contemporary, digitally-mediated collaborative dynamics – including the role played by tutors and the situated nature of group development – robust and innovative methodologies are needed. In this paper, we illustrate how integrating qualitative methods with quantitative tools used in qualitative ways makes it possible to trace how tutors adapt their style to support group development, which in turn triggers student development in a circular and responsive process. To make visible this contemporary phenomenon, we combine thematic content analysis – a qualitative tool – with a quantitative method: Social Network Analysis. Drawing on data generated by two WhatsApp learning groups (six students and four academic tutors) in research exploring the collaborative construction of boundary objects in a master’s level “E-learning Psychology” course, we suggest that our methodological approach has the potential to support interrogation of complex and dynamic digitally-mediated group interactions. Our results show the situational nature of an effective tutorship style through its complex adaptation to learners’ maturity, digital tools, and learning goals

    Residenze Universitarie inclusive e accessibili. Il progetto del recupero del compendio architettonico “Lina Meneghetti” a Padova

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    The 'Lina Meneghetti' architectural complex, consisting of a 16th-century building of considerable historical-architectural value, flanked by, and connected to, a 1950s building, was the subject of a restoration and refunctionalization project to be used as a residence for university students. The integration of design disciplines, restoration, structural engineering and plant engineering technologies has allowed the development of a proposal capable of guiding the design choices through a multidisciplinary approach aimed at the functionality of a specialized typology and, at the same time, at the conservation and enhancement of the historical-artistic heritage. The contribution reports the main phases of the case study with particular attention to the urban and social quality in relation to the inclusiveness of the historical building in the city centre. The experience was approached with the awareness that a residential structure, in order to be truly inclusive, must allow all users to move and orient themselves independently and safely

    The Landscape of IgA Nephropathy Treatment Strategy: A Pharmacological Overview

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    IgA Nephropathy (IgAN) is the most common form of primary glomerulonephritis and is one of the most common causes of end-stage kidney disease (ESKD) worldwide. The immunopathogenic mechanism underlying IgAN is poorly identified. Currently, the mainstay treatment of IgAN is centered on the optimization of blood pressure and a reduction in proteinuria, using an angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs). According to KDIGO, patients who persistently remain at a high risk of progressive ESKD, despite maximal supportive care, are candidates for glucocorticoid therapy. Recent discoveries regarding the pathogenesis of this disease have led to the testing of new therapeutic drugs targeting, in particular, the excessive mucosal immune reaction and the resulting systemic response as well as the complement activation and the following kidney damage and fibrosis. In this review, we examine the various therapeutic approaches to this intriguing disease

    ANALYSIS OF CANDIDATE GENES ON CHROMOSOMES 5q AND 19p IN COELIAC DISEASE.

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    BACKGROUND AND AIM: Celiac disease (CD) is a multifactorial disease with involvement of both environmental and genetic susceptibility factors. The HLA-DQ loci account for 2000 CD patients and 4000 control individuals) question the role of MYO9B at the CELIAC4 locus as a disease-causing gene. Moreover, none of the investigated SNPs explain the linkage at the CELIAC2 locus
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