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Increasing Inpatient Volume and Efficiency Through Decreasing Readmission Rates at Fox Chase Cancer Center

Author: Victorin Islande
Pokallus Courtney
Publication venue
Publication date: 2023
Field of study

This paper outlines the semester long strategic plan created by Islande Victorin and Courtney Pokallus for Fox Chase Cancer Center. This strategic plan includes a background of the organization, SWOT analysis on the organization, identification of potential problems and a gap analysis, a strategic summary, and all outlines and plans for the strategic plan

Arcadia University

Full-term pregnancy induces a specific genomic signature in the human breast

Author: Balogh Gabriela Andrea
Russo Irma H.
Fox Chase Cancer Center Hospital Network Participants
Russo José
Publication venue
Publication date: 16/01/2008
Field of study

Breast cancer riskhas traditionally been linked to nulliparity or late first full-term pregnancy, whereas young age at first childbirth, multiparity, and breastfeeding are associated with a reduced risk. Early pregnancy confers protection by inducing breast differentiation, which imprints a specific and permanent genomic signature in experimental rodent models. For testing whether the same phenomenon was detectable in the atrophic breast of postmenopausal parous women, we designed a case-control study for the analysis of the gene expression profile of RNA extracted from epithelial cells microdissected from normal breast tissues obtained from 18 parous and 7 nulliparous women free of breast pathology (controls), and 41 parous and 8 nulliparous women with history of breast cancer (cases). RNA was hybridized to cDNA glass microarrays containing 40,000 genes; arrays were scanned and the images were analyzed using ImaGene software version 4.2. Normalization and statistical analysis were carried out using Linear Models for Microarrays and GeneSight software for hierarchical clustering. The parous control group contained 2,541 gene sequences representing 18 biological processes that were differentially expressed in comparison with the other three groups. Hierarchical clustering of these genes revealed that the combined parity/absence of breast cancer data generated a distinct genomic profile that differed from those of the breast cancer groups, irrespective of parity history, and from the nulliparous cancer-free group, which has been traditionally identified as a high-risk group. The signature that identifies those women in whom parity has been protective will serve as a molecular biomarker of differentiation for evaluating the potential use of preventive agents.Fil: Russo, José. Breast Cancer Research Laboratory. Fox Chase Cancer Center; Estados UnidosFil: Balogh, Gabriela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; ArgentinaFil: Russo, Irma H.. Breast Cancer Research Laboratory. Fox Chase Cancer Center; Estados UnidosFil: Fox Chase Cancer Center Hospital Network Participants

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