13,668 research outputs found
An interdisciplinary study of information systems: Christopher Alexander and IS failure.
No full textThis paper describes work carried out at the University of York; its contents do not represent the views or opinions of BT. It provides an example of how insights into the field of IS can be gained by looking at it from the perspective of other academic disciplines. Based on the idea that physical and virtual office spaces exist to serve parallel organisational requirements, it is argued that designers of information systems (IS) should be able to learn from the experience of architects in order to improve their methods and redefine their objectives. Firstly, the work of Christopher Alexander is reviewed to show how his work on architectural patterns has been of value to the designers object-oriented systems. Secondly, similarities in the literature between notions of failure in architecture and IS design are identified. These are then examined through interviews with practitioners to establish the relevance of the approach. Finally, the area that Alexander described as ‘the quality without a name’ is highlighted as a topic for further research.Information Systems, Patterns, Virtual Office, Christopher Alexander
Replication Data for: Evaluating the Effects of Shelter-in-Place Policies during the COVID-19 Pandemic
No full textThis data set contains the data and code necessary to replicate all tables and figures in "Evaluating the Effects of Shelter-in-Place Policies during the COVID-19 Pandemic," by Christopher Berry, Anthony Fowler, Tamara Glazer, Samantha Handel-Meyer, and Alec MacMillen
On discourse and materiality: personhood in the Neolithic of the Isle of Man
No full textThis research project takes a fresh look at the Neolithic archaeology of the Isle of Man, using that material to evaluate a number of themes in contemporary archaeology. The theme of personhood in prehistory is most central to the study. This project discusses the prevalent interpretative schemes which archaeologists use to understand prehistoric people, prehistoric bodies, and prehistoric social relationships. As such it joins with a number of current themes in archaeological interpretation, most notably; the role of phenomenology in inferring past experience; the use of ethnographic analogy in understanding past and present ideas and experiences of the person and body; the impact of modernity in forming current ideas of the person (particularly the impact on archaeological thought); and the relationship between the material world, social activity and discourse, both in modernity and in prehistory. Two main types of theory are employed in this project. Both are geared towards understanding social relationships and the way that personhood is generated through activity. The first theory is a theory of performativity, adapted from the work of Judith Butler. The second is a relational approach to personhood, following the work of Marilyn Strathern and other social and cultural anthropologists. These approaches offer a critical basis for the re-consideration of past and present bodies, and past and present relations of personhood. They also provide the basis for reinterpreting past material culture, architecture and landscapes. The project situates archaeology as a product of different modern discourses, and argues that these have shaped the interpretation of past discourses. It sets out todeconstruct those present discourses, and re-evaluate the role of conflicting experiences of the self and world in the present. In this approach concepts of archaeological units; the house; the culture; the individual; the family; are all open to question. They are considered as types of metonym which condition archaeological interpretation. By refuting the authority of these metonyms, and by illustrating how they have become sedimented inarchaeological discourse (specifically for the Neolithic on the Isle of Man), the project explores the possibilities for more context-specific interpretations. Finally, this thesis offers some new interpretations of Neolithic activity on the Isle of Man, interpretations which focus more on the social production of self and world than on capturing the 'meaning' of the past. These interpretations are not totalising, but partial, and seek to explore the possibility of conflict and subversion in Neolithic activities
Interview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American City
No full textInterview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American Cit
Regulation of Outer Membrane Porins in P. aeruginosa Strains Collected from Patients with Cystic Fibrosis
No full textPseudomonas aeruginosa is a versatile opportunistic pathogen capable of causing a variety of serve and chronic infections in healthy and immunocompromised hosts. Individuals with the genetic disorder, cystic fibrosis, are particularly susceptible to P. aeruginosa infections, leading to higher morbidity and mortality in this patient population. In the CF lung environment, this microorganism is subjected to stressful conditions including chronic antibiotic exposure, elevated sodium chloride levels, reduced oxygen availability, and variable nutrient content. Under these variable and often hostile conditions, P. aeruginosa is able to rapidly develop resistance to antibiotics and alter its cellular physiology and metabolism to successfully colonize, grow, and survive. These adaptations have been associated with specific outer membrane porins of P. aeruginosa and their ability to affect cell structure and stability, adhesion to surfaces, and transport of small molecules. However, little is known about how P. aeruginosa is able to adapt and persist within the CF airways. In part, the lack of knowledge in this area can be attributed to the majority of studies conducted on laboratory adapted and/or derived P. aeruginosa strains. The experiments described in this dissertation sought to determine how P. aeruginosa emerges resistant to antibiotics and how specific porins are regulated under different growth conditions typically found in the CF lung environment. It was hypothesized that the regulation of antibiotic resistance determinants and outer membrane porins of P. aeruginosa involves multiple regulatory mechanisms and is dependent on specific environmental cues found in the hostile CF lung environment. Multiple isogenic panels of carbapenem-resistant P. aeruginosa mutants and clinical P. aeruginosa strains in addition to the prototypic strain PAO1were used to test this hypothesis. Four main findings resulted from testing this hypothesis. 1) The novel ISPa8 element was associated with the emergence of carbapenem resistance through the inactivation of the OprD porin in P. aeruginosa, along with an increased expression of the mexAB-oprM efflux pump with a concomitant down-regulation or loss of the OprD porin. 2) Carbapenem exposure can select mutants that exhibit increased susceptibility to multiple antibiotics, which is not associated with modifications in the expression of chromosomal resistance mechanisms or loss of plasmid(s). 3) The OpdQ porin was found to be associated with but not required for P. aeruginosa to exhibit increased susceptibility to antibiotics. Transcriptional analysis demonstrated opdQ transcription was initiated from a single σ70-like promoter, and requires DNA sequences directly upstream of the -35 promoter element. Under elevated sodium chloride, nitrate-rich, and oxygen-poor conditions, transcript and protein levels varied within and among the clinical strains indicating OpdQ is regulated by multiple regulatory mechanisms at the transcriptional and post-transcriptional levels, and its regulation is dependent on specific growth environments. 4) Transcription of the OprF porin gene was initiated equally by σ70 and σX-dependent promoters, and only weakly by a distal σ22-dependent promoter. In addition, the -10 element of the σ70-dependent promoter was shown to be required for oprF transcription. The transcription and production of OprF were affected by the presence of sodium chloride in a majority of the clinical strains, whereas nitrate-rich and oxygen-poor conditions did not. Taken together, these findings suggest that P. aeruginosa perceives and responds to specific environmental cues by modulating antibiotic resistance determinants and porins through multiple levels of regulation. The mechanisms that contribute to the regulation of porins in the presence of nitrate, sodium chloride, and/or oxygen-limiting conditions will still need to be elucidated.ProQuest Traditional Publishing Optionxxvi, 390 page
10-0283 EPPS v. FOWLER
No full text10-0283 Christopher N. Epps and Laura L. Epps v. Bruce Fowler Jr. and Stephanie L. Fowler from Williamson County and the Third District Court of Appeals, Austin For petitioners: Mr. N. West Short, Georgetown For respondents: Mr. Frank B. Lyon, Austin In
EPN906154 Supplemental Material - Supplemental material for Bridging the gap between geographic concept and the data we have: The case of labor markets in the USA
No full textSupplemental material, EPN906154 Supplemental Material for Bridging the gap between geographic concept and the data we have: The case of labor markets in the USA by Christopher S Fowler and Leif Jensen in Environment and Planning A: Economy and Space</p
Matt Christopher Papers - Accession 1309
No full textThe collection includes letters written by the children’s book author, Matt Christopher, to his son, Marty Christopher. Many of the letters also contain newspaper articles of interest to Matt Christopher, which deal with local sports teams, his writing career, his participation in an exhibition baseball game against the New York Giants in 1938, and other of general interest. Most of the letters are personal in nature, however, a majority of the letters delve into Matt Christopher’s writing career, personal interests, the author’s health, as well as his family life.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/2649/thumbnail.jp
Matt Christopher Papers - Accession 1221
No full textMatt Christopher (1917-1997) was a prolific author of children’s books having written over 100 books as well as over 300 short stories, articles, poems, and screenplays. Most of his writings dealt with sports themes, but he also wrote fantasy and mystery themed stories as well. The Matt Christopher Papers consist of both published and unpublished manuscripts, articles, and short stories. Also included are personal and business correspondence, biographical information, scrapbooks, photographs, and memorabilia.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1976/thumbnail.jp
Dr. Christopher von Rueden – Faculty Author Interview
No full textDr. Christopher von Rueden, an anthropologist and Assistant Professor in the Jepson School of Leadership Studies, discusses a recent article entitled, “Men’s status and reproductive success in 33 non-industrial societies: Effects of subsistence, marriage system, and reproductive strategy,” which he co-authored with Dr. Adrian Jaeggi, an anthropologist at Emory University. Their findings were recently published in the journal, Proceedings of the National Academy of Sciences
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