91 research outputs found
Cathepsin F of Teladorsagia circumcincta is a recently evolved cysteine protease
No full text© The Author(s) 2020. Parasitic cysteine proteases are involved in parasite stage transition, invasion of host tissues, nutrient uptake, and immune evasion. The cysteine protease cathepsin F is the most abundant protein produced by fourth-stage larvae (L4) of the nematode Teladorsagia circumcincta, while its transcript is only detectable in L4 and adults. T. circumcincta cathepsin F is a recently evolved cysteine protease that does not fall clearly into either of the cathepsin L or F subfamilies. This protein exhibits characteristics of both cathepsins F and L, and its phylogenetic relationship to its closest homologs is distant, including proteins of closely related nematodes of the same subfamily
Carta sobre el progreso de la conversión indígena en la Misión del Santísimo Rosario de Viñadaco, 1775 septiembre 10
No full textCarta de Fray Manuel Pérez y Fray Francisco Galisteo a Fray Vicente Mora reportando sobre el progreso de la conversión en la Misión del Santísimo Rosario de Viñadaco. En el informe, los dominicos brindan un breve desglose del número de personas que han "convertido". Luego dan un relato detallado de una confrontación que tuvo el capitán español que los acompaña con hombres indígenas hostiles, uno de ellos llamado Macapa. Los frailes indican que la enfermedad aquejaba a la comunidad indígena, proporcionando algunas cifras de la población enferma. El relato también describe otras excursiones que realizaron los frailes a comunidades cercanas, expresando la necesidad de más soldados dada la hostilidad que experimentaban. —— Letter from Fray Manuel Pérez and Fray Francisco Galisteo to Fray Vicente Mora reporting on their progress indoctrinating Indigenous people at Mission of Santísimo Rosario de Viñadaco. In the report, the Dominicans provide a brief breakdown of the number of people they have "converted". They then provide a detailed account of a confrontation the accompanying Spanish captain had with hostile Indigenous men, one of them named Macapa. The friars indicate that illness was afflicting the unfriendly Indigenous community, providing some population numbers on the ill. The account also describes other excursions the friars made to nearby communities, expressing the need for more soldiers to accompany them given the hostility they encounter. 2 f. (4 p.
Experiencing Debussy's sound: a phenomenological approach
No full textThis paper applies phenomenological concepts regarding music to concrete musical examples, namely the first movement of Debussy's La mer. It explores the compositional techniques inherent in his composition that govern how they present themselves to the consciousness of the listener, thereby affecting his or her perception. This phenomenological approach recognizes the experiential features of music and broadens the historically informed methods of analysis in adherence to the definition of music as an experience. The author of this paper adopts the views of the founding father of phenomenology, Edmund Husserl, and the renowned researcher in the field, F. Joseph Smith. Of primary importance are the structures of time-consciousness that unify a musical work as a single phenomenon (called akoumenon by Smith), as the listener perceives music sounding in time. The philosophical discussion that constitutes the first half of this paper will be followed by the phenomenological analysis of Debussy's "De l'aube a midi sur la mer," using the procedure introduced in the musicologist Lawrence Ferrara's research
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Prison of the Setting Sun: A Translation of Ono Fuyumi's Rakushō no goku
No full textIn this thesis, I have presented my translation of the novella Rakushō no goku (落照の獄) by Ono Fuyumi, preceded by a critical introduction. In this introduction, I have provided brief biographical information about the author, context for the story and its place in the Twelve Kingdoms series of novels, an analysis of the story's use of the death penalty as allegory, and an explanation for some of my choices in the translation. In my introduction, my main purpose was to present the author, who has written multiple best-selling, award-winning novels that have received both popular and critical acclaim, yet has received little notice abroad and even less scholarly attention both in and out of Japan, as a writer meriting further study. To this end, I have used my own translation of Rakushō no goku as a primary example of the depth and value of her work, presenting my reading of the conflict in Rakushō no goku as an oblique criticism of the death penalty in Japan, and attempting to tie the story into a longstanding literary tradition of using the fantastic as allegory in order to comment on and critique contemporary culture.Master of Arts (M.A.
Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
No full textSARS-CoV-2 Tests: Bridging the Gap between Laboratory Sensors and Clinical Applications
No full textThis is the author accepted manuscript. The final version is available from the American Chemical Society via the DOI in this recordThis review covers emerging biosensors for SARS-CoV-2 detection together with a review of the biochemical and clinical assays that are in use in hospitals and clinical laboratories. We discuss the gap in bridging the current practice of testing laboratories with nucleic acid amplification methods, and the robustness of assays the laboratories seek, and what emerging SARS-CoV-2 sensors have currently addressed in the literature. Together with the established nucleic acid and biochemical tests, we review emerging technology and antibody tests to determine the effectiveness of vaccines on individuals
The responsiveness and validity of the Rotator Cuff Quality of Life (RC-QOL) index in a 2-year follow-up study
No full textBackground: The Rotator Cuff Quality of Life (RC-QOL) index was developed to evaluate quality of life in patients with rotator cuff disease. This study provides additional psychometric testing in accordance with the Consensus-Based Standards for the Selection of Health Measurement Instruments guidelines. Methods: This was a 2-year follow-up study on 66 patients (mean age, 59 ± 10 years) originally presenting with chronic full-thickness rotator cuff tears to a tertiary care center. The methodology involved testing internal consistency, content validity, and criterion validity. Responsiveness was evaluated using 3 strategies: 1) standardized response mean of the raw change scores; 2) Guyatt’s Responsiveness Index; and 3) Global Rating Scales of improvement correlated to a quality of life measure. Results: Content validity was confirmed with a Cronbach a of 0.92 (95% confidence interval, 0.92-0.95) and absence of floor and ceiling effects. Criterion validity was confirmed using the Western Ontario Rotator Cuff Index as a reference standard (r ¼ 0.87, P < .001). The effect size of distribution-based methods of determining responsiveness was large (0.99-1.09) compared to that of mixed- and anchorbased methods (0.47-0.89). All responsiveness calculations met minimum requirements for acceptable thresholds. Conclusion: The RC-QOL is a valid and responsive measure of health-related quality of life in patients with chronic rotator cuff pathology. The results of this study added to the methodologic quality assessment of the RC-QOL, completarticl
The Natural Products Atlas 2.0: a database of microbially-derived natural products
No full textWithin the natural products field there is an increasing emphasis on the study of compounds from microbial sources. This has been fuelled by interest in the central role that microorganisms play in mediating both interspecies interactions and host-microbe relationships. To support the study of natural products chemistry produced by microorganisms we released the Natural Products Atlas, a database of known microbial natural products structures, in 2019. This paper reports the release of a new version of the database which includes a full RESTful application programming interface (API), a new website framework, and an expanded database that includes 8128 new compounds, bringing the total to 32 552. In addition to these structural and content changes we have added full taxonomic descriptions for all microbial taxa and have added chemical ontology terms from both NP Classifier and ClassyFire. We have also performed manual curation to review all entries with incomplete configurational assignments and have integrated data from external resources, including CyanoMetDB. Finally, we have improved the user experience by updating the Overview dashboard and creating a dashboard for taxonomic origin. The database can be accessed via the new interactive website at https://www.npatlas.org
ENDOTHELIAL VASODILATOR FUNCTION IN NORMAL WEIGHT ADULTS WITH METABOLIC SYNDROME
No full textMetabolic Syndrome (MetS) typically presents with obesity; however, obesity is not a requisite characteristic for MetS classification and related vascular risk. We tested the hypothesis that MetS, independent of excess adiposity, is associated with impaired endothelial vasodilator dysfunction. Thirty-two sedentary, middle-aged adults were studied: 11 normal weight (9 M/2 F; BMI 24.0±0.3 kg/m2); 11 normal weight with MetS (9 M/2 F; 24.7±0.3 kg/m2); and 10 obese without MetS (8 M/2 F; 31.4±0.5 kg/m2). MetS was established according to NCEP ATP III criteria. Forearm blood flow (FBF) responses to intra-arterial infusions of acetylcholine and sodium nitroprusside were measured via strain-gauge plethysmography. FBF responses to acetylcholine were ~20% lower (PThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Neurochemical and cognitive changes precede structural abnormalities in the TgF344-AD rat model
No full textRaw data for manuscript accepted in Brain Communications, awaiting official publication. All datasets contain subject information and modality-specific data. Data was acquired longitudinally at four timepoints from hemizygous TgF344-AD rats (transgenic AD model bred on a Fischer 344 background) and wildtype littermates.
1) Barnes Maze probe data. Probe data acquired 48 hours after last training trial.
2) Magnetic Resonance Spectroscopy data: absolute concentrations are provided, as well as relative to total creatine.
3) Magnetic Resonance Imaging data: absolute brain volumes generated from absolute jacobians. "Brain-size-corrected" volumes are referred to as "relative" volumes and are generated from relative jacobians.This research was supported by the Canadian Institutes of Health Research (PJT-148751) and the Fonds de la Recherche en Santé du Québec (Chercheur boursiers # 0000035275). C.F.F. is supported by funding provided by McGill University's Faculty of Medicine Internal Studentship and Healthy Brains for Healthy Lives Doctoral Fellowship
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