2,862 research outputs found
Reformulating the rj-McMC Algorithm for 3D Inversion of Passive Seismic Data for Near-Surface Characterization
No full textGeophysical subsurface characterization techniques could, due to their non-invasive nature, play a crucial role in the design and subsequent construction of infrastructure in urban & industrial environ- ments. Geo-data specialist company Fugro sees potential in upgrading their current ambient-seismic- noise-tomography workflow, to make use of state-of-the-art inversion schemes with the main goal of increasing the quality and accuracy of the initial-site characterization delivered to clients. In this thesis I explore the feasibility of utilizing the reverse-jump Markov chain Monte Carlo (rj-McMC) algorithm for the inversion of ambient seismic noise for characterization in urban & industrial environments. Specif- ically, testing the potential of scaling down this inversion algorithm to fit in a small scale, near-surface framework. To achieve this, I first carried out analyses to evaluate the appropriate Rayleigh wave frequency range, after which realistic noise hyperparameters, suited for this reduced scale problem, were obtained. Because of the potential exploitation of in-situ borehole measurements, I reformulated the Bayesian prior within the rj-McMC algorithm to implement these constraining shear wave velocity values appropriately. I conducted extensive synthetic experiments to gain insight into the behavior of this adapted algorithm, from which it was concluded that the inherent dynamic discretization partially prevents these constraints from being implemented to their full extent. Nevertheless, promising results lead me to conclude that the use of the rj-McMC algorithm for application in near-surface urban & industrial environments is feasible.Applied Geophysics | IDEA Leagu
Androgen receptors and experimental bone loss - an in vivo and in vitro study
No full textTestosterone is a sex hormone that exhibits many functions beyond reproduction; one such function is the regulation of bone metabolism. The role played by androgen receptors during testosterone-mediated biological processes associated with bone metabolism is largely unknown. This study aims to use a periodontal disease model in vivo in order to assess the involvement of androgen receptors on microbial-induced inflammation and alveolar bone resorption in experimental bone loss. The impact of hormone deprivation was tested through both orchiectomy and chemical blockage of androgen receptor using flutamide (FLU). Additionally, the direct effect of exogenous testosterone, and the role of the androgen receptor, on osteoclastogenesis were investigated. Thirty male adult rats (n=10/group) were subjected to: 1-orchiectomy (OCX); 2-OCX sham surgery; or 3-OCX sham surgery plus FLU, four weeks before the induction of experimental bone loss. Ten OCX sham-operated rats were not subjected to experimental bone loss and served as healthy controls. The rats were euthanized two weeks later, so as to assess bone resorption and the production of inflammatory cytokines in the gingival tissue and serum. In order to study the in vitro impact of testosterone, osteoclasts were differentiated from RAW264.7 cells and testosterone was added at increasing concentrations. Both OCX and FLU increased bone resorption, but OCX alone was observed to increase osteoclast count. IL-1β production was increased only in the gingival tissue of OCX animals, whereas FLU-treated animals presented a decreased expression of IL-6. Testosterone reduced the osteoclast formation in a dose-dependent manner, and significantly impacted the production of TNF-α; FLU partially reversed these actions. When taken together, our results indicate that testosterone modulates experimental bone loss, and that this action is mediated, at least in part, via the androgen receptor.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)National Institute of Health (NIH)Departamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara (FOAR), Universidade Estadual Paulista (UNESP), Araraquara, SP, BrasilDepartment of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA, USADepartamento de Formação Específica, Faculdade de Odontologia, Universidade Federal Fluminse (UFF), Nova Friburgo, RJ, BrasilDepartamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara (FOAR), Universidade Estadual Paulista (UNESP), Araraquara, SP, BrasilDepartment of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA, USADepartamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara (FOAR), Universidade Estadual Paulista (UNESP), Araraquara, SP, BrasilDepartamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara (FOAR), Universidade Estadual Paulista (UNESP), Araraquara, SP, BrasilFAPESP: 2010/12021-4FAPESP: 2010/09658-0CNPq: 470870/2011-7CAPES: 5258-11-1NIH: DE015566NIH: DE02090
Clowns, Fools, and Killers: An Exploration of Horror, Comedy, and Madness Through the Roles of Murderer 2 and Sir Richard Ratcliffe in William Shakespeare\u27s Richard III
No full textThis document is a thesis submitted in partial fulfillment of the Master of Fine Arts degree in Theatre Arts with a Concentration in Musical Theatre. It is a detailed account of author RJ Magee’s artistic and scholarly process in creating the roles of Murderer 2 and Sir Richard Ratcliffe in William Shakespeare’s Richard III. The production was performed as part of Minnesota State University, Mankato’s mainstage season in October of 2022. In five chapters, this thesis chronicles the actor’s process: a preproduction analysis, a historical and critical perspective, a rehearsal and performance journal, a post-production analysis, and a process development analysis. Appendices and works cited are included
Neurological and cognitive decline in adolescence
No full textThe evaluation of progressive neurological and/or cognitive decline poses one of the greatest challenges to the paediatric neurologist. While the potential causes are individually quite rare, collectively neurodegenerative disorders are quite common with an incidence of approximately 0.5/1000 live births.(1) Faced with an individual child, it is easy to feel daunted by textbooks\u27 that tend to be organised according to pathology, rather than presentation, and which emphasise that many of these conditions have "variants" that can present at widely differing ages. Confusing terminologies, and non-specific presentations, tend to add to a sense of despair at ever getting to grips with the field. Confining the scope of this paper to conditions presenting in adolescence limits the number of conditions under discussion, simplifying matters considerably. However, considerations pertinent to the evaluation of progressive disease across the paediatric age range still arise
Efficient translational rehabilitation randomised controlled trial designs using disease progress modelling and trial simulation
No full textGiven the challenges inherent in randomised trials of rehabilitation interventions, methods are required to increase trial efficiency and information yield. This paper discusses, in a non-technical manner, a class of statistical models that is particularly suited to the task of detecting potential treatment effects against a background of spontaneous change
Voices from the past : Feuerstein, R., Rand, Y., Hoffman, M. et al.: Cognitive modifiability in retarded adolescents: Effects of Instrumental Enrichment ; American Journal of Mental Deficiency 83: 539–550, 1979.
No full text
Back to the future: rehabilitation of children after brain injury
No full textA mistaken optimism persists that outcomes for childhood acquired brain injury (ABI) are in general superior to those for similar injuries in adults, a misconception based on naive concepts of greater \u27plasticity\u27 in the immature brain. The challenges of rehabilitation after ABI, of bringing children \u27back\u27 to face the \u27future\u27 of completing childhood development with an injured brain, are reviewed in the context of the science of brain recovery from injury. Unrealistic expectations of recovery may cause subsequent events to be perceived as academic or employment \u27failure\u27. The challenges of supporting children and families after ABI are reviewed
Voices from the past: Cognitive modifiability in retarded adolescents: effects of instrumental enrichment
No full text
- …
