23 research outputs found
A comparison of the recycle and no-recycle options in light water reactors
No full textThe author wishes to express his appreciation to Dr. Forrest J. Remick for the professional guidance and encouragement he provided during this study, and also to Dr. Warren F. Witzig for his assistance in the preparation of this work. This work and the author's course of study were made possible by the U. S. Naval Postgraduate Educational Program.http://archive.org/details/acomparisonofrec109451804
Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72-hour continuous infusion with and without dipyridamole.
No full text During a phase I trial of 3-day simultaneous continuous intravenous infusions of varying doses of fluorouracil (5FUra) and 7.7 mg/kg/d of dipyridamole, we examined the relationships between 5FUra dose and steady-state plasma concentration (Css) and the percentage reduction in WBCs, as well as the percentage frequency of stomatitis. The 5FUra was administered at doses ranging from 185 mg/m2/d times three to 3,600 mg/m2/d times three. In 42 patients, 86 cycles of 5FUra plus dipyridamole and 28 cycles of 5FUra alone were analyzed. The Css of 5FUra varied even within the same dose level. When patients receiving the same 5FUra dose were considered, the interpatient coefficient of variation of 5FUra Css in cycles of 5FUra plus dipyridamole was 23% +/- 4.2%. For courses of 5FUra alone, the coefficient of variation of 5FUra was 15.6% +/- 6.5%. When the occurrence of any degree of stomatitis was related to the Css 5FUra, with patients grouped in cohorts of 2-mumol/L increments, the following equations accurately described the frequency of stomatitis: for 5FUra plus dipyridamole, percentage frequency of stomatitis = 100(1-e-0.114Css), r2 = 0.88; for 5FUra alone, percentage frequency stomatitis = 100(1-e0.122Css), r2 = 0.80. When 5FUra dose was substituted for Css, these relationships were as follows: percentage frequency of stomatitis = 100(1-e-0.00031 [dose]), r2 = 0.85; and percentage frequency of stomatitis = 100(1-e-0.00051 [dose]), r2 = 0.80. When the relationship between the percentage reduction in WBC and Css 5FUra was examined, statistically significant relationships were also apparent: for 5FUra plus dipyridamole, percentage reduction in WBC = 100(1-e-0.085Css), r2 = 0.46; for 5FUra alone, percentage reduction in WBC = 100(1-e-0.060Css), r2 = 0.61. When 5FUra dose was substituted for Css, these relatinships were as follows: percentage reduction in WBC = 100(1-e-0.00023 [dose]), r2 = 0.40; percentage reduction in WBC = 100(1-e-0.00024 [dose]), r2 = 0.65. The relationship between either Css 5FUra or dose 5FUra and either stomatitis or myelosuppression were also well described by the modified Hill equation (J Theor Biol 20:171-201, 1968). These analyses indicate that it should be possible to develop therapeutic regimens wherein 5FUra is administered to achieve a targeted Css determined by the risk and severity of toxicity deemed acceptable. </jats:p
Songs of San Francisco
No full text48 p.; With an introduction by Evelyn Wells, famous California author, and a foreword by Frank E. Feliz, Director of Publications, Golden Gate International Exposition. At head of title: Souvenir song book of 1939 worlds fair on San Francisco Bay. On cover: Containing new and old California songs including: California, here I come; Illustrated with pictures of the exposition and latest views of the San Francisco Bay Area; Other Composers and Lyricists as noted: "California Here I Come" By Al Jolson, Bud de Sylva and Joseph Meyer; "Abalone Song" Verses by: George Sterling, Jack London, Ambrose Bierce, Gelett Burgess. Music adapted by: Sterling Sherwin; "Telygraft Hill" Words by: Wallace Irwin. Music by: John Milton Hagen; "The Ballad of Mr. Cooke" Words by: Bret Harte. Music by: John Milton Hagen; "Chinatown, My Chinatown" Words by: William Jerome. Music by: Jean Schwartz; "San Francisco Fog" Words by: Wallace Irwin. Music by: John Milton Hagen; "California, My Homeland" Lyric by: J. Keirn Brennan. Music by Ernest R. Ball; "Out San Francisco Way" Words by: Vincent Bryan and Sam Marley. Music by: Gertrude Hoffman; "A Chinatown Ballad" Words by: Wallace Irwin. Music by: John Milton Hagen; All other songs not noted, credited to Sterling Sherwin
Sweet butter.
No full textGift of Dr. Mary Jane Esplen.By the author of "Yes! We have no bananas" [note]Piano vocal [instrumentation]Right near the drugstore on our street there is a restaurant [first line]Sweet butter sweet butter sweet butter on my toast [first line of chorus]C major [key]Moderato [tempo]Popular song [form/genre]Man, butter dish; photo: Dell Lampe and his orchestra [illustration]Starmer [engraver]Publisher's advertisement on back cover [note
Water Quality Control Through Flow Augmentation
No full textABSTRACT
To evaluate effects of flow augmentation from upground reservoirs on water quality, studies of the relationship between water quality and flow volume were undertaken in a 60-mile section of the Sandusky River in North Central Ohio.
Chemicals such as calcium, magnesium, fluoride and sodium, which enter the river primarily as components of ground and surface runoff water, had lower concentrations at high flow volumes and higher concentrations during low flow periods. In contrast, for most river sections concentrations of total phosphorus and soluble orthophosphorus were lower during low flow periods and increased as flow volume increased. These increases in phosphorus concentration were probably due to agricultural surface runoff. Immediately downstream from sewage treatment plants, orthophosphorus concentrations did increase with decreasing river flow. During most of the study period the total phosphorus flux at the downstream station was much less than the total upstream input from sewage treatment plants. Nitrate and potassium concentrations were variable and showed no correlation with river flow.
Oxygen concentrations were near saturation at medium and high flows but varied widely above and below saturation at low flows. It was concluded that in most river sections algal respiration rather than B.O.D. was responsible for low D.O. values. It is predicted that flow augmentation will significantly reduce algal growth in the stream. This effect would probably arise from increased flow velocity rather than dilution of algal nutrients.
This report was submitted in fulfillment of Grant 16080 DFO under the sponsorship of the Environmental Protection Agency.This study was an outgrowth of consultations with the Ohio Department of Natural Resources. Thanks are especially due to Mr. A. F. Woldorf of the Division of Water who was instrumental in setting up the early planning and coordination for this project. Mr. J. J. Molloy, District Chief of the U.S. Geological Survey, has been extremely helpful throughout this project in supplying stage-discharge tables, interim water flow data and interim water
quality data.
The Environmental Protection Agency is to be thanked, not only for supporting this project, but also for the technical support extended by Dr. M. W. Lammering and Mr. B. Smith of the National Field Investigations Center in Cincinnati and Messrs. G. Harlow, E. Kramer and C. Klevene of the Lake Erie Program Office. The loan of a fluorometer system for dye tracer studies from the National Field Investigation Center and a current meter from the Lake Erie Program Office is greatly appreciated. The help of the Project Officer, Dr. W. R. Duffer of the National Water Quality Control Research Program, Water Quality Office, Environmental Protection Agency, Robert S. Kerr Water Research Center, is also greatly appreciated.
The participation of several of our colleagues in the science departments at Heidelberg College contributed greatly to this project. These include Dr. J. J. Jackobs of the Computer Center, Mr. R. A. Wise of the Physics Department, Dr. D. Allenson of the Chemistry Department (now with the Division of Water Pollution Control, Department of Public Utilities, Cleveland, Ohio), and Mr. E. T. Ashworth of the Geology Department. Student technicians who participated in the study included B. Remick, J. Lather, and R. Stanforth.
The work of Mrs. D. B. Baker and Mrs. G. D. Knutson in preparing the figures and tables and in typing the final manuscript has been greatly appreciated by the authors
Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood
No full textAim : To elucidate the mechanisms underlying homocysteine (Hcy)-induced chemokine production. Methods : Human whole blood was pretreated with inhibitors of calmodulin (CaM), protein kinase C (PKC), protein tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK), and NF-ΚB and activators of PPARΓ for 60 min followed by incubation with Hcy 100 Μmol/L for 32 h. The levels of mitogen chemokine protein (MCP)-1 and interleukin-8 (IL-8) were determined by enzyme-linked immunosorbant assay (ELISA). Results : Inhibitors of PKC (calphostin C, 50-500 nmol/L and RO-31-8220, 10–100 nmol/L), CaM (W7, 28–280 Μmol/L), ERK1/2 MAPK (PD 98059, 2–20 Μmol/L), p38 MAPK (SB 203580, 0.6–6 Μmol/L), JNK MAPK (curcumin, 2–10 Μmol/L), and NF-ΚB (PDTC, 10-100 nmol/L) markedly reduced Hcy 100 Μmol/L-induced production of MCP-1 and IL-8 in human cultured whole blood, but the inhibitors of PTK (genistein, 2.6–26 Μmol/L and tyrphostin, 0.5-5 Μmol/L) had no obvious effect on MCP-1 and IL-8 production. PPARΓ activators (ciglitazone 30 Μmol/L and troglitazone 10 Μmol/L) depressed the Hcy-induced MCP-1 production but not IL-8 production in the cultured whole blood. Conclusion : Hcy-induced MCP-1 and IL-8 production is mediated by activated signaling pathways such as PKC, CaM, MAPK, and NF-ΚB. Our results not only provide clues for the signal transduction pathways mediating Hcy-induced chemokine production, but also offer a plausible explanation for a pathogenic role of hyperhomocysteinemia in these diseases.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75644/1/j.1745-7254.2005.00005.x.pd
Serious Music Survey Forms Filled Out by Florence Price for Selected Compositions to Be Submitted to ASCAP
No full textHome Copy
Serious Music Survey
AMERICAN SOCIETY OF COMPOSERS, AUTHORS and PUBLISHERS
30 ROCKEFELLER PLAZA * NEW YORK 20, N.Y.
FORM 3. Use this form for VOCAL ENSEMBLES requiring three or more singers, with or without instrumental accompaniment
(excepting those requiring orchestral accompaniment.)
Section I.
(a) COMPOSER'S NAME Florence B. Price (b) CITIZENSHIP AMERICAN
(c) TITLE OF COMPOSITION [Moonbridge]
(d) (e)
IF TITLE IS NOT IN ENGLISH, GIVE TRANSLATION ON THIS LINE OPUS No.
(f) SUBTITLE, if any
(g)
TITLES OF INDIVIDUAL MOVEMENTS
(h) (i) (j) (k) ASCAP
COMPOSED (YEAR) PERFORMANCE TIME FOR EACH MOVEMENTS TOTAL PERFORMANCE TIME WHO CONTROLS PERFORMANCE RIGHTS?
(l) Remick Music Corp (m) 1950
IN WHOSE NAME IS COPYRIGHT HELD? DATE OF COPYRIGHT
(n) (o)
IF THERE IS A TEXT, GIVE NAME OF AUTHOR PUBLISHER TEXT
(p) HAVE YOU OBTAINED PERMISSION TO USE TEXT FROM COPYRIGHT HOLDER? Yes (q) Florence B. Price
IF THIS IS AN ARRANGEMENT, GIVE NAME OF THE ORIGINAL COMPOSER
SECTION 2. Is this composition intended for Chorus or for Vocal Ensemble? Yes, for either, (women)
CHECK SINGERS REQUIRED:
X First SOPRANO(S) X First ALTO(S) First TENOR(S) First BARITONE(S) First BASS(ES)
X Second SOPRANO(S) Second ALTO(S) Second TENOR(S) Second BARITONE(S) Second BASS(ES)
Third SOPRANO(S) Third ALTO(S) Third TENIR(S) Third BARITONE(S) Third BASS(ES)
If any soloist (not included in the above indicated ensemble) are required, list them here.
If this work is NOT a cappella, indicate instruments required for accompaniment: Piano
ADDITIONAL INFORMATION My arrgt. of the sup solo, [orig.] [pub,] [by] [Gamble Hanzel]
Mrs [xx], Chigo. Now [pub] [by] [Remick] Mus. [Corp.] N.Y.
SECTION 3. If this composition has been PUBLISHED, fill in this section.
(r) Remick Mus. Corp (s) 1950
NAME OF PUBLISHER YEAR PUBLISHED
(t) IS SCORE PRINTED: Yes (u) PRICE OF SCORE
(x) ARE SCORE AND PARTS BOTH FOR RENT? (y) ARE ONLY THE PARTS FOR RENT?
(z)
IF PUBLISHER IS NOT RENTAL AGENT, GIVE NAME AND ADDRESSES OF AGENT ON THIS LINE
SECTION 4. If this composition is UNpublished, but CONTROLLED BY AGENT, fill in this section.
(aa) (bb) MAY SCORE AND PARTS BE RENTED FROM AGENT?
NAME AND ADDRESS OF AGENT
SECTION 5. If this composition is UNPUBLISHED, and is NOT controlled by an agent, fill in this section.
(cc) ARE SCORE AND PARTS AVAILABLE FOR PERFORMANCES? (dd) WOULD YOU BE ABLE AND WILLING TO FURNISH A COPY OF THE SCORE FOR A REFERENCE LIBRARY?
NOTE: Use a separate sheet for each composition. Fill out SECTIONS 1 and 2 and appropriate sections among SECTIONS 3, 4,
5 and 6. Information requested under SECTIONS 7, 8, 9, and 10 is optional.
PLEASE SIGN ON REVERSE (OVER
Calcitonin Gene-Related Peptide Partially Reverses Decreased Production of Chemokines KC and MIP-2 Following Murine Sepsis
No full textThe secretion of calcitonin gene-related peptide (CGRP) and the chemokines KC and MIP-2 are increased in the animal models of endotoxemic and septic shock. We tested whether CGRP could modulate KC and MIP-2 secretion from different sources of macrophages after murine sepsis induced by cecal ligation and puncture (CLP). Macrophages were obtained from the peritoneal exudate and lung of female BALB/c mice 16 h after CLP and plated in culture with CGRP and/or LPS for 12 h. The results showed that peritoneal macrophage production of the chemokines (KC, MIP-2) and cytokines (TNF-α, IL-6) was markedly decreased in CLP mice. Alveolar macrophages did not display decreased cytokine/chemokines production after CLP. CGRP (0.1 nM–10 nM) partially reversed this decreased production of LPS-induced KC and MIP-2 from peritoneal macrophages. These results suggest that CGRP might be intimately involved in recruitment of neutrophils by promoting local production of the chemokines KC and MIP-2 in murine sepsis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44531/1/10753_2004_Article_376569.pd
