547 research outputs found
El Tlacuache Núm. 365 (2009). 365 Año 9 (2009) mayo. El Tlacuache
No full textRubén Jaramillo: las intenciones del crimen por Aura Hernández. - Jaramillo y la disputa el sentido de la vida por Flavio Barbosa. - De campesinos a obreros: una comunidad surgida entre las flores por Rafael Gutiérrez
Personnalisation et leadership Le cas du Mouvement Cinq Étoiles
No full textThe article draws a characterisation of the late comer among the Italian populist parties, the Five Star’ Movement, led by the ancient comedian Beppe Grillo. Starting with a definition of what he means by “political personalisation”, the Author first describe this party as a political organisation in which the leader masters all the key areas – notably, communication, rules setting, and resolution of internal conflicts. Then, he argue that the Five Star Movement is a “personalist party”, in which Beppe Grillo embodies a powerful but non-charismatic leader. In the closing section, the Author tries to shed light above the probable evolutions of the party, particularly dealing with its institutionalisation process
Outcome of treating advanced neuroendocrine tumours with radiolabelled somatostatin analogues
No full textTo evaluate the initial response and outcomes (quality of life and presence of side effects) in patients with advanced neuroendocrine tumours (NET) after treatment with radiolabelled somatostatin analogues: (90)Y-DOTATyr3- octreotide ((90)Y-DOTATOC) and (177)Lu-DOTA-Tyr3- octreotate ((177)Lu-DOTATATE)
Un capitolo della fortuna delle "Decades" di Biondo Flavio: da Pio II a Giovanni Albino
No full textL’articolo concentra l’attenzione sul contenuto del ms. München, Bayerische Staatsbibliothek, Clm 11 324, descritto dal catalogo come «Albini Lucani excerpta ex Blondi decadibus». Ma il codice non contiene gli excerpta delle Historiae ab inclinatione Romano rum imperii di Biondo Flavio, bensí una sintesi della Abbreviatio supra Decades Blondi di papa Pio II. L’autore Giovanni Albino Lucano, storiografo e curatore della biblioteca dei re aragonesi di Napoli, nella dedica al re Alfonso II non fa alcuna menzione del testo di Pio II da lui usato. L’epitome offre una curiosa attestazione indiretta della fortuna di Biondo Flavio, il quale intrattenne diverse relazioni con la corte napoletana di Alfonso il Magnanimo.This article focuses on the contents of MS Munich Bayerische Staatsbibliothek, Clm 11324, described in the catalogue as «Albini Lucani excerpta ex Blondi decadibus». But the MS does not contain the excerpts of the ‘Historiae ab inclinatione Romanorum imperii’ of Biondo Flavio, but a summary of the ‘Abbreviatio supra Decades Blondi’ by Pope Pius II. The author, Giovanni Albino Lucano, historian and librarian for the Aragonese kings of Naples, makes no mention in his preface of the work by Pius II which he had used. The epitome is a curious indirect proof of the influence of Biondo Flavio, who had various contacts with the Neapolitan court of Alfonso il Magnanimo
Correction: Muniz-Santos et al. The Influence of Competition Day Loads on the Metabolic and Immune Response of Olympic Female Beach Volleyball Athletes: A Sportomics Analysis. Nutrients 2025, 17, 1924
No full textFlavio Bachini was not included as an author in the original publication [...
Radiopeptide imaging and therapy in Europe
No full textReceptor targeting with radiolabeled peptides has become an important topic, particularly in nuclear oncology. Strong research efforts are under way in radiopharmaceutical science laboratories and in nuclear medicine departments in Europe. The target receptors belong to the large family of G-protein–coupled receptors. The prototypes of these radiopeptides are based on analogs of somatostatin targeting somatostatin receptor–positive tumors, particularly well-differentiated neuroendocrine tumors. These radiopeptides have an important impact not only on diagnosis but also on targeted radionuclide therapy of these tumors. Besides the registered radiopeptide 111In-pentetreotide, efficient SPECT tracers labeled with 99mTc and PET agents based on generator-produced 68Ga have been developed and used in the clinic. In parallel to the development of diagnostic agents, radiopeptides labeled with the β− emitters 90Y and 177Lu are also widely used. Because the same chelators and therefore the same conjugates can be used in diagnosis and therapy, they constitute ideal theranostic pairs. This progress is driven not only by scientists and clinicians but also by patient interest groups. New radiopeptides targeting other G-protein–coupled receptors are entering the clinic, among them glucagon-like peptide 1 receptor–targeting molecules. This receptor is overexpressed on literally all benign insulinomas. 111In-labeled derivatives of the insulinotropic 39-mer peptide exendin-4 were beneficial in the pre- and perioperative localization of these benign lesions. In contrast, lack of localization may indicate malignant insulinoma. The bombesin- and gastrin-releasing peptide receptor family is potentially important because these receptors are overexpressed on major human tumors such as prostate tumors, breast tumors, gastrointestinal stromal tumors, and vessels of ovarian cancer. 99mTc-labeled peptides for SPECT and 68Ga-, as well as 64Cu-labeled agonists or antagonists, have been studied in breast tumors, prostate tumors, gastrointestinal stromal tumors, and gliomas with considerable success. A phase I therapeutic study with a 177Lu-labeled agonist has been completed. There are not enough clinical data available to reveal the significance of these new modalities in patient care, but several phase I studies are under way in larger patient cohorts using PET agents. Another G-protein–coupled receptor with high overexpression on human tumors is the gastrin/cholecystokinin-2 receptor. It is overexpressed in more than 90% of cases of medullary thyroid cancer, in small cell lung cancer, and in a subgroup of neuroendocrine tumors. Correlating with in vitro receptor localization using autoradiography of 27 patients with metastasized medullary thyroid cancer, SPECT or planar imaging of these patients resulted in a 95% sensitivity of tumor localization. Finally, another G-protein–coupled receptor is found in brain tumors and peritumoral vessels. Literally all cases of glioblastoma multiforme overexpress the neurokinin type 1 receptor; the natural ligand is substance P, which was metabolically stabilized, labeled with 90Y and 213Bi, and injected into resection cavities or directly into tumors, which were critically located via a catheter system. The major advantage of this approach appeared to be the facilitated resectability of tumors, particularly in those patients who had been treated up front with the locoregional approach. It appears that neoadjuvant treatment before resection is a valid concept. Finally, another peptide family, the arginine-glycine-aspartate–based radiotracers, has made it to the clinic labeled with a variety of radioisotopes for monitoring the integrins αvβ3 overexpressed during tumor angiogenesis
Dopo la trincea: Gramsci, “L’Ordine Nuovo” e la rivoluzione italiana
No full textThrough the articles written by Antonio Gramsci during the first year and a half of release of “L’Ordine Nuovo”, you can see the development lines of what the author has established during the World War I on the historical and political analysis of Italian and European society. These ideas deal directly with Factory Council’s doctrine: Gramsci, inspired by the voluntary initia-tives in Turin factories, builds, since the summer of 1919, a revolutionary theory gathered on the role of working-class institutions. The extensive task of the Factory, in a devastated post-war industrial society, forces the political thinker to reshape the traditional functions of the two representative proletarian institutions: Labor Union and Political Party. Only rethinking about how they work, it’s possible to lead to success the revolutionary movement of the most aware Italian workers: from Turin industries can arise the future construction of Italian Soviet repub-lic that, after the victory of the Revolution in all countries, will be melted in international communist society. This theory stands in a particular position between socialist thinkers of that period, not only towards Reformists or Unitarians Maximalists, but also towards elements of the Communist faction that breaks up with the PSI during national congress of Livorno (Janu-ary 1921) to create a new revolutionary Party
Targeted radionuclide therapy: current status and potentials for future improvements
No full texttarget cell while the absorption of the radioactivity in non-target tissue should be as low as
achievable. Usually, this goal is reached by coupling the radionuclide to a vector which
recognises a structure, e.g. receptor, on the target cell. By far the most established
combination is the somatostatin receptor (sst) and radiolabeled somatostatin analogues.
The majority of neuroendocrine tumours feature a strong over-expression of the somatostatin
receptors (sst), mainly subtype 2 (sst2). Somatostatin receptors are attractive targets for
radiolabelled peptides since the density of sst on tumours is vastly higher than on non tumour
tissue. In addition to the favourable receptor distribution, sst2 internalises into the cell
after a ligand bound to the receptor. Consequently, radioactivity delivered by the vector is
captured in the target cell after binding
17. Dall’etica alla politica: potenza e atto della virtù umana in Dante, tra Convivio e Monarchia
No full textThis paper moves from an analysis of the connection, in Dante’s Monarchia, between the activity of the Monarcha, who establishes the general Law, by which men can regain philosophical(-moral) virtue, and the multitudo, which includes all individuals and countries congregated in the political Empire. It is only in this universal political system that, according to Dante, humankind actualizes both intellectual and practical virtues. Possible only as a result of a righteous individual experience of life, in fact, virtue becomes actual if pursued within the collective experience of humankind as a whole, to be intended exactly as a unified and universal Monarchy. Dante can, therefore, show in the Latin treatise three stages of the human life on earth, where peculiar conditions of virtue are linked to specific political situations: 1. the individual, undermined by sin in his own rational nature, lives in a world where, since there is no universal authority, conflict prevails; 2. human beings can restore their potential of virtue and intellect, if they choose to follow the teachings of the Monarch; 3. this condition occurs when the human race, through a collective action, has reached the act of philosophy, living in a world ruled as a multitude. In defining such a harmonious project of the human wills (concordance in aims and purposes, which concerns all individuals ruled by the perfect philosopher/king), Dante’s treatise relies on the coeval Aristotelian sources. In particular, the author intertwines the fundamental Averroistic issues with the synthesis elaborated by Thomism thus creating an innovative theoretical frame that includes rational, ethical and theological aspects of human beings as political animals, intended by Nature (as a consequence of the will of Providence) to live together in perfect peace
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