1,721,338 research outputs found

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    Presentazione della poesia di Miłosz nell'ambito del Festival "Venezia di Miłosz" (Direzione: Francesca Fornari - Jarosław Mikołajewski

    Wprowadzenie

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    Presentazione della poesia di Miłosz nell'ambito del Festival "Venezia di Miłosz" (Direzione: Francesca Fornari - Jarosław Mikołajewski

    Wprowadzenie

    No full text
    Presentazione della poesia di Miłosz nell'ambito del Festival "Venezia di Miłosz" (Direzione: Francesca Fornari - Jarosław Mikołajewski

    On the importance of CI/CD practices for database applications

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    Continuous integration and continuous delivery (CI/CD) automate software integration and reduce repetitive engineering work. While the use of CI/CD presents efficiency gains, in database application development, this potential has not been fully exploited. We explore the state of the art in this area, with a focus on current practices, common software tools, challenges, and preconditions that apply to database applications. The work is grounded in a synoptic literature review and contributes a novel generic CI/CD pipeline for database system application development. Our generic pipeline was tailored to three industrial development use cases in which we measured the benefits of integration and deployment automation. The measurements demonstrate clearly that introducing CI/CD had significant benefits. It reduced the number of failed deployments, improved their stability, and increased the number of deployments. Interviews with the developers before and after the implementation of the CI/CD show that the pipeline brings clear benefits to the development team (i.e., a reduced cognitive load). These findings put current database release practices driven by business expectations, such as fixed release windows, in question

    MicroRNA and hepatocellular carcinoma: biology and prognostic significance

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    Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the third most common cause of cancer-related death worldwide. In 90% of cases, HCC arises on a background of cirrhosis which, in turns, results from hepatitis (HBV and HCV) infections, alcohol abuse, metabolic disorders including NASH, and genetic metabolic diseases, autoimmune hepatitis, primary biliary cirrhosis and exposure to environmental carcinogens. The molecular mechanisms underlying HCC development are still only partially known. Despite a high molecular variability, the deregulation of definite oncogenic pathways has been confirmed as a common finding in HCC. Among these, the molecular ways controlling proliferation, apoptosis and migration play a major role. In recent years, a new class of regulatory RNAs, the microRNAs, has been discovered and their deregulated expression has been linked to the molecular pathogenesis of many cancers because of their ability to strongly impact on the expression of crucial messenger RNAs. This review focuses on some of the most relevant evidence concerning the contribution of microRNA aberrant expression to HCC developmen

    Robustness and Consequence Based Assessment of an Existing Dam

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    Robustness plays a relevant role in the capacity of a structure to sustain abnormal loads or to deal with unexpected events with large effects, such as explosions and terroristic attacks. Such situations on dams may have extremely large consequences. For buildings, the design approach that best implements robustness concepts is represented by the so called "Consequence Based Design": even if nothing is known about the cause, selective element removals and extreme load on the structure are modeled, and their effects are determined with respect to progressive collapse and damage arrest. In the paper we try to set-up a "Consequence Based Assessment" of a typical example of a gravity dam built between the ‘30s and ‘40s of the last century in the northwestern Italian Alps. A simplified model of the structure is adopted. Removal of parts of the dam cross-section is assumed to occur: the effects of the extent of damage is discussed on the bases of the tension generated within the body of the da
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