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PC-Based Decision-Support System for Trinity River, Texas
No full textTextA personal computer (PC) based decision-support system (DSS) can provide real-time information for improved flood prevention and control in the Trinity River basin in Texas. It uses specialized versions of the well-known programs HEC-1 and HEC-5 for forecasting runoff and simulating reservoir operation, respectively. The DSS integrates these components with a specialized program manager. Although not yet used as designed, potential improved flood prevention and control with the DSS are demonstrated with historical storm data.David Ford Consulting Engineers, Inc. and Halff Associates, Inc.Center for Water and the Environmen
A PC parallel port button box provides millisecond response time accuracy under Linux
No full textFor psychologists, it is sometimes necessary to measure people's reaction times to the nearest millisecond. This article describes how to use the PC parallel port to receive signals from a button box to achieve millisecond response time accuracy. The workings of the parallel port, the corresponding port addresses, and a simple Linux program for controlling the port are described. A test of the speed and reliability of button box signal detection is reported. If the reader is moderately familiar with Linux, this article should provide sufficient instruction for him or her to build and test his or her own parallel port button box. This article also describes how the parallel port could be used to control an external apparatus
1949 Ford Pirsch PC-67 500 _ GM taken 1976
No full textPhotograph of Claremore FD 1949 Ford-Pirsch pumper
Millisecond accuracy video display using OpenGL under Linux
No full textTo measure people’s reaction times to the nearest millisecond, it is necessary to know exactly when
a stimulus is displayed. This article describes how to display stimuli with millisecond accuracy on a
normal CRT monitor, using a PC running Linux. A simple C program is presented to illustrate how this
may be done within X Windows using the OpenGL rendering system. A test of this system is reported
that demonstrates that stimuli may be consistently displayed with millisecond accuracy. An algorithm
is presented that allows the exact time of stimulus presentation to be deduced, even if there are relatively
large errors in measuring the display time
1949 Ford Pirsch PC-67 500 _ GM factory photo
No full textPhotograph of Claremore FD 1949 Ford-Pirsch pumper. Factory photo taken at the completion of building the truck
Frontmatter (Titlepage, Table of Contents, Author List, PC List, Reviewer List)
No full textFront matter including table of contents, author list, PC list, and reviewer list
DNA damaging therapies in patients (pts) with prostate cancer (PC) and pathogenic alterations in homologous recombination repair (HRR) genes
No full textBackground: Pathogenic HRR gene mutations may confer sensitivity to PARP inhibitors (PARPi) and/or platinum chemotherapy (chemo). While pts harboring mutations in BRCA1/2 appear to benefit from these DNA damaging therapeutics, outcomes data for those with non-BRCA1/2 mutations are less robust. We evaluated outcomes in men with HRR gene-mutated PC who received treatment with PARPi and/or platinum-based chemo stratified by type of HRR alteration. Methods: Retrospective data from the PROMISE Consortium was utilized (PMID: 34363009). PC pts with pathogenic HRR mutations who received PARPi and/or platinum-based chemo were included. Differences in PSA progression-free survival (PFS), clinical/radiographic PFS (rPFS), and overall survival (OS) between those with BRCA1/2 mutations (Cohort A) and those with mutations in HRR genes that do not directly interact with the BRCA complex (Cohort B: ATM, CDK12, CHEK1, CHEK2, FANCL) were evaluated. We also evaluated outcomes in pts with HRR gene mutations known to interact with the BRCA complex aside from BRCA1/2 (Cohort C: RAD51B/C/D, RAD54L2, BARD1, GEN1, PALB2, FANCA, BRIP1). Results: Of 361 pts identified with HRR gene alterations, 89 received PARPi and 70 received platinum-based chemo. Prior therapy and metastatic disease sites were similar between cohorts. PSA PFS, rPFS, and OS were significantly improved in Cohort A vs. Cohort B with PARPi but not platinum-based chemo (Table). Sample size in cohort C was too small to allow for statistical comparison, although PSA PFS, PFS and OS were reasonably long. Conclusions: PC pts with BRCA1/2 mutations had improved outcomes to PARPi compared to those with mutations in HRR genes not directly interacting with the BRCA complex. Platinum-based chemo appeared effective regardless of which HRR gene was affected
Long-term Cancer Control Outcomes After Robot-assisted Radical Prostatectomy in Pathologically Non-organ-confined High-risk Prostate Cancer: 20-year Report from a Single Tertiary Referral Center
No full textBACKGROUND AND OBJECTIVE: Exhaustive evidence on the long-term efficacy of robot-assisted laparoscopic prostatectomy (RALP) in non-organ-confined high-risk prostate cancer (PC) is still lacking. Our aim was to evaluate long-term oncological outcomes in this subset of patients treated with RALP at a single referral center.
METHODS: We included 803 patients with pathologically non-organ-confined high-risk PC (≥ pT3a and/or pN1) at RALP between 2001 and 2022 at Henry Ford Hospital (Detroit, MI, USA). All patient underwent RALP using the Vattikuti Institute technique, with or without extended pelvic lymph node dissection (external iliac, obturator, and internal iliac nodes). The Kaplan-Meier method was used to estimate overall survival (OS) and additional treatment-free survival. The probability of PC-specific survival (PCSS) was estimated via the competing-risks method. Competing-risk and Cox regression analyses were used to identify potential predictors of PC-specific mortality (PCSM), any-cause mortality (ACM), and additional treatment.
KEY FINDINGS AND LIMITATIONS: We included 803 patients, of whom 415 (51.5%) had pT3a, 385 (47.9%) had ≥ pT3b, 323 (40%) had pN1, and 670 (84%) had grade group 4-5 PC. Of the 635 patients with status information regarding additional treatment, 416 received further therapy after surgery. Specifically, 46, 110, and 260 underwent RT only, HT only, or RT + HT, respectively. Median follow-up was 72 mo (interquartile range 28-120). The 20-yr survival rates were 72.7% (95% confidence interval [CI] 56.8-86,5%) for PCSS and 45.2% (95% CI 29.1-60.1%) for OS. The rates of survival free from additional treatment were 31.3% (95% CI 26.1-36.5%) at 10 yr and 20.3% (95% CI 14.9-26.4%) at 15 yr. Multivariable regression revealed pT3b-4 stage as an independent predictor of PCSM (hazard ratio [HR] 2.50; p = 0.008), ACM (HR 1.84; p = 0.006), and additional treatment (HR 1.69; p \u3c 0.001).
CONCLUSIONS AND CLINICAL IMPLICATIONS: For patients with non-organ-confined high-risk PC, RALP achieves long-term oncological control. This study provides the longest follow-up after RALP as the primary local treatment for patients with truly aggressive PC forms and offers valuable insights for patient counseling on long-term outcomes
[Photograph of Henry Barrenger, public servant with J. Rogers (left) and Kingsland (right) at a reception at the Canberra Rex Hotel, 3 May 1965] [picture] /
No full textTitle devised by cataloguer based on caption on compactus card.; "L50986. Barrenger Reception, Canberra Rex 3/5/65, PC Ford. H Barrenger (centre) with J. Rogers (left) and Kingsland (right)"--On negative bag.; Condition: Good.; AIS no.L50986.; Contact print at BOX PIC/10150.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3663263
High efficiency implementation of PC and PC stable algorithms yields three-dimensional graphs of information flow for the Earth' atmosphere
No full textSeptember 3, 2014.Causal discovery algorithms have recently been applied to several climate applications. In particular, in prior work we have developed methods to recover pathways of interaction in the global climate system, using the classic PC algorithm. However, standard implementations of the PC algorithm cannot handle the large number of variables and temporal models required for this application. This technical report shows that a more efficient implementation of the PC algorithm can provide speed gains of a factor of 1,000 or more. This in turn enables us to calculate graphs of information flow with much higher resolution grids. Furthermore, we can now - for the first time ever - calculate information flow graphs that extend over three dimensions, i.e. rather than just including one layer of the planet's atmosphere we can now capture interactions across several height layers
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