1,117 research outputs found
Supplemental_Material_Covalent_BTK_by_Harris,_et_al – Supplemental material for Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton’s Tyrosine Kinase
No full textSupplemental material, Supplemental_Material_Covalent_BTK_by_Harris,_et_al for Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton’s Tyrosine Kinase by Christopher M. Harris, Sage E. Foley, Eric R. Goedken, Mark Michalak, Sara Murdock and Noel S. Wilson in SLAS Discovery</p
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Three Air Quality Studies: Great Lakes Ozone Formation and Nitrogen Dry Deposition; and Tucson Aerosol Chemical Characterization
No full textThe Clean Air Act of 1970 was promulgated after thousands of lives were lost in four catastrophic air pollution events. It authorized the establishment of National Ambient Air Quality Standards or (NAAQS) for six pollutants that are harmful to human health and welfare: carbon monoxide, lead, nitrogen dioxide, particulate matter, ozone and sulfur dioxide. The Clean Air Act also led to the establishment of the United Stated Environmental Protection Agency (US EPA) to set and enforce regulations. The first paper in this dissertation studies ozone in the Lake Michigan region (Foley, T., Betterton, E.A., Jacko, R., Hillery, J., 2011. Lake Michigan air quality: The 1994-2003 LADCO Aircraft Project (LAP). Atmospheric Environment 45, 3192-3202.) The Chicago-Milwaukee-Gary metropolitan area has been unable to meet the ozone NAAQS since the Clean Air Act was implemented. The Lake Michigan Air Directors' Consortium (LADCO) hypothesized that land breezes transport ozone precursor compounds over the lake, where a large air/water temperature difference creates a shallow conduction layer, which is an efficient reaction chamber for ozone formation. In the afternoon, lake breezes and prevailing synoptic winds then transport ozone back over the land. To further evaluate this hypothesis, LADCO sponsored the 1994-2003 LADCO Aircraft Project (LAP) to measure the air quality over Lake Michigan and the surrounding areas. This study has found that the LAP data supports this hypothesis of ozone formation, which has strong implications for ozone control strategies in the Lake Michigan region. The second paper is this dissertation (Foley, T., Betterton, E.A., Wolf, A.M.A., 2012. Ambient PM10 and metal concentrations measured in the Sunnyside Unified School District, Tucson, Arizona. Journal of the Arizona-Nevada Academy of Science, 43, 67-76) evaluated the airborne concentrations of PM10 (particulate matter with an aerodynamic diameter of 10 microns or less) and eight metalloids and metals (arsenic, beryllium, cadmium, chromium, cobalt, lead, manganese, and nickel) in the southern Tucson metropolitan area. A Tucson company that uses beryllium oxide to manufacture thermally conductive ceramics has prompted strong citizen concern. This study found that the study area has good air quality with respect to PM₁₀ and metals, with ambient concentrations meeting US Environmental Protection Agency and World Health Organization standards. Beryllium was detected only once (during a dust storm) and was ascribed to naturally-occurring beryllium in the suspended soil. The third paper (to be submitted to the Journal of Great Lakes Research) studies nitrogen dry deposition over Lake Michigan and Lake Superior. Numerous studies have shown that wet and dry deposition of nitrogen has contributed to the eutrophication of coastal waters and declining productivity of marine fisheries. Nitrogen dry deposition over the Great Lakes themselves, as opposed to the shorelines, has not been documented in the peer-reviewed literature. This paper calculates nitrogen dry deposition over Lake Michigan and Lake Superior, using aircraft measurements from the LADCO Aircraft Study, and finds that over-water, nitrogen dry deposition is a significant source of nitrogen to Lake Michigan and Lake Superior
The Course and Predictors of Patient Participation in Inpatient Occupational Therapy: Understanding the Impact on Outcomes and Implementation Barriers
No full textAbstract
Date Presented 3/31/2017
Patient participation (engagement) is a keystone of patient-centered care. This study provided evidence to support how active participation in occupational therapy would enhance patient outcomes at discharge and 1 yr postinjury. We also identified barriers to patient participation in rehabilitation.
Primary Author and Speaker: Alex Wong
Contributing Authors: Christina Papadimitriou, Arielle Goldsmith, Katrina Christopher, Gale Whiteneck, Anne Deutsch, Eric Lenze, Allen W. Heinemann</jats:p
Self-directed work teams at an aerospace company
No full textThesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1995.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (leaf 79).by Eric C. Sorenson.M.S
Can Iterative Learning Control (ILC) mediated by Functional Electrical Stimulation (FES) be used in the re-education of upper limb function post stroke?
No full text"Where now the harp?" Listening for the sounds of Old English verse, from Beowulf to the twentieth century
No full textAdditional multimedia to accompany this article is available from http://journal.oraltradition.org/issues/24ii/jonesThis essay examines the representation or staging of oral performance and poetic composition within Beowulf, in order to argue that poem thematizes and mythologizes its own origins, and is as much interested in recovering the sounds of oral performances that pre-date its own manuscript inscription as modern Anglo-Saxon scholarship has been. The second half of the essay considers the recovery and reimagining of an Anglo-Saxon “soundscape” in the work of two twentieth-century poets, W. S. Graham and Edwin Morgan. The invocation of this “Saxonesque” patterning of sound invokes or triggers a historically constituted set of associations with the whole body of Old English poetry; that is, an allusion to a corpus, rather than to a specific text, is made through sound patterning.Peer reviewe
Distribution, density, and habitat associations of the narrowly endemic coldwater crayfish (faxonius eupunctus) in the Eleven Point River drainage, Arkansas and Missouri, U.S.
No full textNorth America harbors an exceptionally high number of rare or narrowly distributed crayfishes, and many of these species are threatened with displacement by a variety of biological, chemical, and physical factors. Detailed distributional and ecological data are lacking for many North American crayfishes, making the assignment of appropriate conservation protection designations difficult. A better understanding of the distribution, population densities, and habitat associations of rare and narrowly distributed crayfishes is therefore warranted to most effectively protect and manage these species. The purpose of this research was to assess the distribution and local population densities of the narrowly endemic Coldwater Crayfish (Faxonius eupunctus) in the Eleven Point River drainage, Arkansas and Missouri, U.S. My principle objectives were to: (1) assess the distribution of F. eupunctus within the Eleven Point River drainage to further evaluate its potential use of tributary streams; (2) estimate local F. eupunctus population densities to determine where the species is most abundant; and (3) investigate physical habitat variables relating to, and potentially influencing, local F. eupunctus densities. I used multiple sampling approaches, including environmental DNA sampling, to assess the distribution, density, and habitat of F. eupunctus throughout the Eleven Point River drainage. Faxonius eupunctus occurred primarily in the main stem Eleven Point River but was detected in a downstream reach of one of its largest tributary streams. Faxonius eupunctus site densities were highest in the middle reaches of the species’ range in the main stem Eleven Point River, and my analyses showed that F. eupunctus density was strongly related to current velocity, in-stream temperature, and streambed substrate size. Results from this study corroborate evidence from previous research in supporting that F. eupunctus is restricted to large streams within its range. Further, I present new evidence that F. eupunctus is most abundant in the middle reaches of its range in the main stem Eleven Point River, and I discuss a variety of local-scale physical habitat variables potentially influencing this noteworthy spatial abundance pattern. I also present support for the use of environmental DNA for the detection of rare lotic-dwelling crayfish species, although I highlight potential limitations of eDNA applications in lotic environments.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-12-01The student, Christopher Rice, accepted the attached license on 2017-12-11 at 16:08.The student, Christopher Rice, submitted this Thesis for approval on 2017-12-12 at 11:08.This Thesis was approved for publication on 2017-12-14 at 13:05.DSpace SAF Submission Ingestion Package generated from Vireo submission #11942 on 2018-03-13 at 09:57:44Made available in DSpace on 2018-03-13T15:28:42Z (GMT). No. of bitstreams: 3
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Deception and Britain's road to war in Iraq
No full textEver since the 2003 invasion of Iraq, there has been a widely shared public perception in the UK and beyond that the British government lied in making the case for war. One major theme has been the view that the Blair government lied about the strength of the intelligence about alleged Iraqi weapons of mass destruction (WMD) and the extent of the WMD capabilities claimed by that intelligence. A second theme that has received less attention has been the view that the Blair government lied in claiming that its actions at the United Nations (UN) were aimed at securing peaceful Iraqi compliance with its disarmament obligations. Instead, most think that the UK was actually committed to a policy of regime change by force and did not want the ‘UN route’ to produce a peaceful outcome. The article argues that the conceptual focus of the discussion needs to be broadened from lying to also considering deception by omission and deception by distortion as part of a campaign of organized political persuasion. It argues that, on the WMD intelligence, it is now apparent that a campaign of deceptive organized political persuasion was conducted by UK officials. With respect to the UN route, there is mounting evidence that the Blair government ran a campaign of deception on this issue as well to pave Britain’s road to war in Iraq
A formal, historical, and interpretive analysis of Equus and October for wind ensemble by composer Eric Whitacre
No full textThe purpose of this essay is to examine two selected works by composer Eric Whitacre: Equus and October. This discussion not only presents a model for performance-practice encompassing analytical and stylistic considerations, but also addresses Whitacre's compositional processes, attitudes on the wind band, and thoughts on contemporary music - all of which gives some greater insight into his compositional psyche. It is through these concepts in combination that we may more fully understand this complex composer and musician known worldwide for his innovative music. Whitacre's Equus, commissioned by Gary Green and the University of Miami Wind Ensemble, and October, commissioned by Brian Anderson and the Nebraska Wind Consortium, dually serve as the foci of the essay. Further, the author uses these works as a springboard for discussion into areas that present Whitacre as an artist, composer and human being. These concepts, while worthy of inclusion, are difficult to substantiate, prove, or even document; likewise, they are often omitted from essays of similar nature. The music of Eric Whitacre has been performed throughout the world and with much acclaim in nearly every genre, including opera. His music and, indeed he, is deserving of a sincere and intense study. Such was the intent of this essay
Development of microbial community structure in turfgrass rootzone mixtures varying by amendment, age, presence of plants, and environment:
No full textThe stability of turfgrass golf green rootzone mixtures depends on the development of a stable microbial community structure. Factors affecting microbial community development are age of the turfgrass, the location of golf greens, and the amendments added. The objective of this study was to evaluate methods for assessment of turfgrass rootzone microbial community structure and function and to apply them to field situations. Methods were identified to evaluate the microbial community in these rootzone mixtures. Metabolic diversity (BIOLOG), dehydrogenase activity, bacterial plate counts, and phospholipid fatty acid analysis were performed on turfgrass green rootzone mixture samples collected from a bench top study, established golf courses, a greenhouse study, and replicated field plots.
The utility of each of the measures of microbial communities in evaluating turfgreen stability varied between the levels of complexitiy of the study (i.e. laboratory vs. greenhouse vs. field situation). In the bench top study, BIOLOG, dehydrogenase activity, and bacterial plate counts revealed differences in the microbial community as affected by the base material of the rootzone (sand, soil) and rate of peat moss amendment. In sampling of established golf courses, BIOLOG showed differences in the microbial community, based on age of the rootzone; it was not clear if these differences were due to age or other factors such as management. In a greenhouse study, BIOLOG showed differences in the microbial community, in rootzones varying by amendement and presence of turfgrass. Fatty acid data indicated some grouping based on amendment. Dehydrogenase and bacterial plate counts did not correlate to amendment or presence of turfgrass. Dehydrogenase did show correlation with bacterial signature fatty acids detected. A final study evaluated replicate field plots varying by amendment and microclimates. BIOLOG showed grouping based on microclimate and amendment. Fatty acid data did not vary based on amendment, yet showed slight, seasonal differences in the microbial community. Dehydrogenase did show correlation with bacterial fatty acids detected.
This research demonstrated that the selected methods of microbial community activity and function were useful for evaluating rootzone mixtures, although it appears that the specific combination of tests used will depend upon the system examined.Ph.D.Includes bibliographical references (p. 270-282).by Eric Richard Gauli
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