500 research outputs found
Differential regulation of the phenazine biosynthetic operons by quorum sensing in Pseudomonas aeruginosa PAO1-N
No full textThe Pseudomonas aeruginosa quorum sensing (QS) network plays a key role in the adaptation to environmental changes and the control of virulence factor production in this opportunistic human pathogen. Three interlinked QS systems, namely las, rhl, and pqs, are central to the production of pyocyanin, a phenazine virulence factor which is typically used as phenotypic marker for analysing QS. Pyocyanin production in P. aeruginosa is a complex process involving two almost identical operons termed phzA1B1C1D1E1F1G1 (phz1) and phzA2B2C2D2E2F2G2 (phz2), which drive the production of phenazine-1-carboxylic acid (PCA) which is further converted to pyocyanin by two modifying enzymes PhzM and PhzS. Due to the high sequence conservation between the phz1 and phz2 operons (nucleotide identity > 98%), analysis of their individual expression by RNA hybridization, qRT-PCR or transcriptomics is challenging. To overcome this difficulty, we utilized luminescence based promoter fusions of each phenazine operon to measure in planktonic cultures their transcriptional activity in P. aeruginosa PAO1-N genetic backgrounds impaired in different components of the las, rhl, and pqs QS systems, in the presence or absence of different QS signal molecules. Using this approach, we found that all three QS systems play a role in differentially regulating the phz1 and phz2 phenazine operons, thus uncovering a higher level of complexity to the QS regulation of PCA biosynthesis in P. aeruginosa than previously appreciated
The Research Potential and Significance of the Egyptian Collections within Yorkshire Museums
No full textThis research project addresses the Research Potential and Significance of Egyptian Material within
Yorkshire Museums. This scoping project ascertains what Egyptian material is present in Yorkshire,
particularly in storage, to open the material up for further study.
This material has been put under little or no examination in the past, with the exception of the ongoing
studies of Dr. J. Fletcher. There have been several cases, highlighted by Fletcher, of museums that hold a
significant and unique collection of Egyptian artefacts that were hitherto unknown, an example being
Harrogate Museums and Arts. This lack of knowledge is not only in the public domain but also present in
the knowledge of museums themselves.
Through highlighting the material that is present in Yorkshire, the project has identified specific areas of
research that can be expanded on. Research potential is discussed constantly throughout the thesis,
indicating how significant this material is.
This thesis also highlights the local significance of the material, which is a contentious issue as Egyptian
material is clearly not excavated within Yorkshire. The author has argued that once assimilated into
museum or private collections, the material becomes part of the local history.
This study records many items of individual interest for future study as well as addressing conditions in
which the materials are currently held. This includes consideration of material damage and corrosion, which
in some cases is ongoing and requires attention.
Public awareness has been a strong influence in the development of this research. Through studying and
highlighting this material, it is anticipated that museums can be encouraged to better utilise their
collections and to construct a foundation for further academic research. This research also comes at a
pertinent time, with museums being hard hit by funding and budget cuts, which are noted to have affected
the study and display of Egyptian material
A short account of the malignant fever, lately prevalent in Philadelphia [electronic resource] : with a statement of the proceedings that took place on the subject in different parts of the United States. By Mathew Carey.
No full textAlso issued as the fifth title in: Select pamphlets: viz. 1. Lessons to a young prince .. Philadelphia : Published by Mathew Carey, 1796 (Evans 31172).Two states noted. In one, the last word on p. 61 is "un-". In the other, the last word is "'till".Partial list of those who died in Philadelphia between August and November, 1793, p. 100-103.Statistics gathered in Philadelphia, August to November, 1793, including meteorological observations compiled by David Rittenhouse, [9] p. at end.Signatures: [A]p4s B-Np4s Op2s Pp2sEvans,Austin, R.B. Early Amer. medical imprints,Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Correction to: The role of resection in hepatocellular carcinoma BCLC stage B: A multi-institutional patient-level meta-analysis and systematic review (Langenbeck's Archives of Surgery, (2024), 409, 1, (277), 10.1007/s00423-024-03466-x)
No full textCorrection to: Langenbeck’s Archives of Surgery (2024) 409:277. https://doi.org/10.1007/s00423-024-03466-x. This article unfortunately contained a mistake. The author name ‘Mathew Vithayathil’ was incorrectly written as ‘Vithayathil Mathew K.’. The original article has been corrected
[George Washington Parke Custis, half-length portrait, three-quarters to the left, wearing white waistcoat]
No full textBuilder and original owner of Arlington House, later the Lee Mansion, Arlington (Va.); author, historian, artist (painter).Identification from The Atlas, August 26, 1849, p. 1.Scratched on back of plate: 207; Custis, G.W.P.Original served by appointment only.Produced by Mathew Brady's studio.Transfer; U.S. War College; 1920; (DLC/PP-1920:46153).Forms part of: Daguerreotype collection (Library of Congress)
[Xavier Donald MacLeod, half-length portrait, nearly facing front, with mustache and spectacles]
No full textAuthor, teacher, editor of the St. Louis Leader.Alternative identification: McLoud.Scratched on back of plate: Mc-Loud. Written in ink on back of plate: 434.Identification from engraving by Capewell & Kimmel in Knickerbocker Gallery, 1854, p. 135.Original served by appointment only.Produced by Mathew Brady's studio.Transfer; U.S. War College; 1920. (DLC/PP-1920:46153).Forms part of: Daguerreotype collection (Library of Congress)
Author Correction:Global diversity and biogeography of bacterial communities in wastewater treatment plants (Nature Microbiology, (2019), 4, 7, (1183-1195), 10.1038/s41564-019-0426-5)
No full textIn the version of this Article originally published, the name of the author ‘Mathew Robert Brown’ was incorrectly written as ‘Mathew Brown’ in the main author list and as ‘Matthew Brown’ in the Global Water Microbiome Consortium list. In addition, in the Global Water Microbiome Consortium list, the names of the authors ‘Kevin F. Boehnke’, ‘Janeth Sanabria’ and ‘Adalberto Noyola’ were incorrectly written as ‘Kevin Boehnke’, ‘Janeth Sanabria Gómez’ and ‘Adalberto Noyola Robles’, respectively. The names have now been corrected and the author initials in the author contributions section updated accordingly.</p
Author Correction:Global diversity and biogeography of bacterial communities in wastewater treatment plants (Nature Microbiology, (2019), 4, 7, (1183-1195), 10.1038/s41564-019-0426-5)
No full textIn the version of this Article originally published, the name of the author ‘Mathew Robert Brown’ was incorrectly written as ‘Mathew Brown’ in the main author list and as ‘Matthew Brown’ in the Global Water Microbiome Consortium list. In addition, in the Global Water Microbiome Consortium list, the names of the authors ‘Kevin F. Boehnke’, ‘Janeth Sanabria’ and ‘Adalberto Noyola’ were incorrectly written as ‘Kevin Boehnke’, ‘Janeth Sanabria Gómez’ and ‘Adalberto Noyola Robles’, respectively. The names have now been corrected and the author initials in the author contributions section updated accordingly.</p
Who is security and privacy research for? Analysis on meta-data from relevant publications
No full textSubmission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01The student, Raima Mathew, accepted the attached license on 2022-04-22 at 10:42.The student, Raima Mathew, submitted this Thesis for approval on 2022-04-22 at 11:41.This Thesis was approved for publication on 2022-04-26 at 15:47.DSpace SAF Submission Ingestion Package generated from Vireo submission #17918 on 2022-11-11 at 12:12:01Security and privacy (S&P) research aims to protect people by mitigating potential risks of technology. While there are many success stories in our field doing just this, the impact of the research remains unclear. The understanding of who is the security and privacy research for can be achieved by exploring the Usable S&P papers along with traditional security privacy papers. I seek to contribute a better understanding of who is the S&P research for by performing an analysis of metadata (e.g., author affiliation, geographic location, user study conducted, citations) of 907 security and privacy papers published at the USENIX Security Symposium (USENIX) and Symposium on Usable Privacy and Security (SOUPS) between 2015 and 2021. In this paper, I present these results and use evidence from prior work to consider the implications of our findings in terms of who benefits most from S&P work. I also highlight the differences and similarities between general S&P, and Usable S&P, along with the prior work on Human-Computer Interaction (HCI). For example, in all three, a disproportionate amount of research is conducted in western countries, which likely means that the work disproportionately addresses the needs of people in those locales and excludes people in other places. I conclude by providing discussions and recommendations to diversify the conference such that it includes different viewpoints, cultures, and values
An investigation into the effects of different warm-up modalities on specific motor skills related to soccer performance
No full textFletcher, IM and Monte-Colombo, MM. An investigation into the effects of different warm-up modalities on specific motor skills related to soccer performance. J Strength Cond Res 24(8): 2096-2101, 2010-The aim of this study was to investigate the effect of different warm-up stretch modalities on specific high-speed motor capabilities important to soccer performance. Twenty-seven male soccer players performed 3 warm-up conditions, active warm-up (WU), WU with static stretching (SPS), and WU with dynamic stretching (ADS). Heart rate, countermovement jump, 20-m sprint, and Balsom agility tests were performed after each intervention. Vertical jump heights were significantly greater (p < 0.01) in the WU and ADS conditions compared to those in the SPS trial. The 20-m sprint and agility times showed that the SPS condition was significantly slower (p < 0.01) than the WU and ADS conditions, with the ADS trial being significantly faster (p < 0.05) than the WU condition. Heart rate was significantly higher (p < 0.01) for participants post-WU and -ADS trials compared to the SPS condition. These findings suggest that the superior performance of the dynamic stretch and warm-up-only conditions compared to the static stretch condition may be linked to increases in heart rate. The reasons for the dynamic stretch trial superiority compared to the warm-up condition are less clear and as yet to be established. We recommend for optimal performance, specific dynamic stretches be employed as part of a warm-up, rather than the traditional static stretches
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