4,997 research outputs found
Fleming, adaptation, and the author biopic
No full textThe mini-series Fleming: The Man Who Would Be Bond, which aired in the U.S. on BBC America and in the U.K. on Sky Atlantic in 2014, offered an entertaining and glamorised account of Ian Fleming, creator of James Bond. Focusing in particular on Fleming’s time during the Second World War, a period in which he served in British Naval Intelligence, successive episodes comprised embroidered accounts of his experiences, with a heavy emphasis on scenes and motifs that chimed with the doings of his most famous character. This approach to the author’s life-story foregrounded the same elements upon which previous small-screen biographies of Ian Fleming had focused, especially his creation of Bond. The TV film Goldeneye: The Secret Life of Ian Fleming (1989) addressed his wartime experiences and subsequent Bond writing, while Spymaker: The Secret Life of Ian Fleming (1990) doubled down on its Bond connections by casting Jason Connery (son of original film 007, Sean Connery) as Fleming in a Second World War adventure with numerous James Bond parallels. Likewise, Ian Fleming: Bondmaker (2005) and Ian Fleming: Where Bond Began (2008) both framed Fleming first and foremost in terms of his literary creation.
With high production values, and a strong cast that included Dominic Cooper, Lara Pulver, and Samuel West, Fleming bore several of the hallmarks of what has come to be called “quality television” (Thompson, 1997) , and was heavily promoted in the weeks running up to its broadcast. However, a contemporary review in Wired by Graeme McMillan saw it as evidence of a problematic tendency in recent biopics. McMillan asserted that while such texts were previously “a mix of entertainment, education and guilt-free voyeurism,” they have become “a contradictory mix of hagiography and revisionism, lionizing their subjects while somehow managing to diminish them in comparison to the products of their imagination” (McMillan, 2014). In this chapter I will look to unpick this contention, and—in particular—to approach Fleming and the author biopic in terms of adaptation
Metabolism and motility of head and neck cancer: characterisation, prognostication and novel target identification
No full textHead and neck cancer (HNSCC) worldwide affects over 500,000 new people each year and overall mortality has remained at 50% despite promising new treatments. Although FDGPET imaging is in widespread clinical practice, the unique metabolic features of this disease and its subtypes remain poorly understood. We have previously identified Cterminal tensin-like (CTEN; TNS4), a member of the TENSIN gene family that encodes focal adhesion adaptor proteins, as being a likely target geneof a cell’s metabolic sensors (CtBPs). CTEN is also emerging as a prognostic marker in many cancer types but its mechanism of action and clinical relevance in HNSCC was unknown.Clinical relevance was examined through tissue microarray immuno histochemistry analysis of 260 consecutively treated oropharyngeal cancer patients, demonstrating CTEN expression to have a significant inverse correlation with disease-specific survival, as well as a determinant of chemoradiotherapy resistance. RNA sequencing analysis andin vivo results helped direct in vitro functional assays, utilising gene knockdown methods, resulting in discovery of a novel CTEN function promoting cell survival in HNSCCcell lines, potentially through a TGFβ-dependent pathway.Linking tumour cell metabolism, we proposed a novel mechanism whereby increasing glycolytic stimuli could regulate CTEN expression via a CtBP2 dependent pathway. We revealed a binding site for the CtBPs on the CTEN promoter viachromatin immuno precipitation analyses. Given the clinical relevance of the human papilloma virus (HPV) in clinical practice,we proceeded to classify the metabolic profiles of both HPV-positive and HPV-negative HNSCC and identified one potential metabolic target, the monocarboxylic acid transporter 1(MCT1). Metabolic profiling confirmed HPV-negative HNSCCas an ideal candidate disease for targeting with a novel MCT1-inhibitor and in vitro treatment resulted in potentially beneficial effects on both metabolic activity and radiosensitivity of cells. We therefore highlighted the potential therapeutic benefits of metabolic agents in novel combination therapy strategies
Jason Bond Family History
No full textJason Bond authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Fall 2017 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]
Jason vs GIJOE
No full textThesis (Master's)--University of Washington, 2019Jason vs GI JOE is partly an exercise in autobiography, an experiment in relational aesthetics, and an interdisciplinary artist project at the intersection of comic books, creative writing and performance art. This comic book, Jason vs. GIJOE, is a postmodern double erasure, based on the comic book GIJOE: Cobra II (Issue 1). The original pictures from the comic book have been removed, and replaced by a series of short narratives, describing autobiographical events from the life of the author: me, Jason. Speech bubbles from the original have been left to comment back over top of the stories, obscuring meaning but creating moments of unplanned dialogue. The comic is a readymade, twice erased: once to replace the drawings of the initial comic, and again when using the original dialogue bubbles to speak back to the narrative
Oral history interview with Jason Poudrier
No full textJason Poudrier, author, discusses growing up in a military family and living in Alaska, North Dakota, Oregon, and finally Oklahoma. He describes what it was like enlisting in the Army after high school in 2001 and how his military service affected him. A recipient of the Purple Heart, he shares his experiences getting injured by shrapnel in Iraq. He later talks about how he uses poetry and writing to cope with his memories of war, and how he hopes to help others do the same.The Deep Roots: Oklahoma Authors Collection is a series of interviews with authors who discuss their lives, work, and creative processes
Lynn Brunelle and Jason Chin: Cook Prize 2025, Gold Medal Acceptance Speech
No full textAuthor Lynn Brunelle and illustrator Jason Chin give an acceptance speech for Life After Whale: The Amazing Ecosystem of a Whale Fall (Neal Porter Books/Holiday House)https://educate.bankstreet.edu/cook/1016/thumbnail.jp
The people behind the papers – Jason Ko and Daniel Lobo
No full textPlanarians grow when they are fed and shrink during periods of starvation. However, it is unclear how they maintain appropriate body proportions as their size changes. A new paper in Development investigates the differences between growth and shrinkage dynamics and builds a mathematical model to explore the mechanisms underpinning these two processes. To learn more about the story behind the paper, we caught up with first author, Jason Ko, and corresponding author, Daniel Lobo, Associate Professor at the University of Maryland.https://doi.org/10.1242/dev.20298
Ep. #085 - Jason W. Moore
No full textThis recording and transcript form part of a collection of podcasts conducted by the Cultures of Energy at Rice University. Cultures of Energy brings writers, artists and scholars together to talk, think and feel their way into the Anthropocene. We cover serious issues like climate change, species extinction and energy transition. But we also try to confront seemingly huge and insurmountable problems with insight, creativity and laughter.Cymene and Dominic talk capital and Vanilla Isis and then (11:21) we welcome to the podcast the one and only Jason W. Moore from Binghamton University, author of Capitalism in the Web of Life (Verso, 2015) and Anthropocene or Capitalocene? (PM Press, 2016). We chat with Jason about his most recent work, co-authored with Raj Patel, A History of the World in Seven Cheap Things (U California Press, 2017), forthcoming this October. We talk about why he wanted to write a book for a broader audience, the problems with the “anthropocene” concept in the human sciences, how “capitalocene” can improve our thinking about world history, and how we can avoid vulgar materialism in critical environmental research and activism today. We cover the role that states and agriculture have played in shaping modern capitalism and Jason calls for a seriously engaged pluralism to tackle the urgent challenges of our era. We discuss the cheapening or thingification of life, capitalism as a gravitational field, the importance of frontiers, the violence of the Great Domestication, and why if green energy remains in the mode of “cheap fuel” nothing will change about capitalist accumulation. Jason explains why racial and gender domination are so often lacunae in critiques of petromodernity. Finally we ruminate on how to unmake the capitalist world-ecology and the key principles of the “reparation ecology” that Jason and his colleagues are calling for. Tired of the debate within the left about whether to prioritize jobs or the environment? Then you’ll want to listen on
NPS Concludes Sleep Study aboard Jason Dunham
No full texthttp://www.navy.mil/submit/display.asp?story_id=71230Article author is Mass Communication Specialist 2nd Class Deven King, USS Jason Dunham Public AffairsUSS JASON DUNHAM, At Sea (NNS) -- Sailors aboard guided-missile destroyer USS Jason Dunham
(DDG 109) concluded their participation in a two-week sleep study, Dec. 17.
The study was conducted by personnel from the Naval Postgraduate School (NPS) who came
aboard Jason Dunham to interview crewmembers about their watch rotations and monitor their
sleep patterns, activity periods and reaction times
- …
