86,550 research outputs found
The need for identifying standardized indices for measuring glucose variability.
No full textWe read the article by Siegelaar and colleagues,1 which clearly suggests the lack of association between glycemic
variability (GV) and oxidative stress estimated by 8-iso-prostaglandin F2α (8-iso-PGF2α) excretion rate in patients with
type 2 diabetes mellitus (T2DM) with good metabolic control by oral glucose lowering agents. We have, however,
some concerns.
As an index of GV, mean amplitude of glycemic excursions (MAGE), one of the most widely used indexes for measuring
GV, was chosen; although a gold-standard procedure is still lacking. In our article,2 we observed a positive correlation
between 8-iso-PGF2α and GV, measured as continuous overall net glycemic action (CONGA-2), in diabetic patients
with short-term disease and optimal metabolic control. However, we were unable to show a significant correlation
between MAGE and 8-iso-PGF2α. The observation of a different behavior between CONGA-2 and MAGE, in terms
of association with oxidative stress, is possibly due to the metabolic characteristics of our patients. In fact, CONGA-2 is
known to detect small glycemic swings, occurring over short-time intervals,3 thus appropriately describing the glycemic
fluctuations of patients in optimal metabolic balance, without peaks and valleys. On the other side, MAGE displays
several limitations, the most important being the arbitrary definition of significant peaks and nadirs in units of
standard deviations. Moreover, the raw glycemic data, obtained by continuous glucose monitoring, are usually asymmetric
(hypoglycemic is much narrower than hyperglycemic range). Hence we believe that because MAGE analysis is based
on the standard deviation value, as a consequence, we can predict that MAGE will preferentially look at hyperglycemic
peaks and will be relatively insensitive to hypoglycemic nadirs.3 Therefore, we suggest applying different indices for
the measurement of GV, depending on the aim of the study and the metabolic characteristics of the studied population.
We should also consider the possible confounding effect of insulin secretagogues and of the various drugs used in the
population studied by Siegelaar and colleagues1 on GV and on oxidative stress parameters.4
In our study, in order to avoid these important confounding factors, we selected patients treated only by either diet
alone or diet plus metformin. On the other side, it should be noted that, in agreement with our data, the population
studied by Siegelaar and associates1 showed an optimal glycemic control, thus excluding the possible interference of
glucotoxicity5 on the results observed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Impact of glycemic variability on cardiovascular outcomes beyond glycated hemoglobin. Evidence and clinical perspectives.
No full textAims: The aim of this review is to focus on intra-day glucose variability (GV),
specifically reviewing its correlation with HbA1c, the methods currently available to measure
it, and finally the relationship between GV and cardiovascular outcomes, in type 1 and type 2
diabetic patients, and in the non-diabetic population.
Data synthesis: The term GV has been used in the literature to express many different
concepts; in the present review, we focus our attention on intra-day GV. In particular, we
try to assess whether GV provides additional information on glycemic control beyond HbA1c,
since GV seems to be incompletely expressed by HbA1c, particularly in patients with good
metabolic control. Many different indexes have been proposed to measure GV, however at
the moment no “gold standard” procedure is available. Evidence in vitro, in experimental
settings and in animal studies, shows that fluctuating glucose levels display a more deleterious
effect than constantly high glucose exposure. However, these findings are not completely
reproducible in human settings. Moreover, the relationship between GV and cardiovascular
events is still controversial.
Conclusions: The term GV should be reserved to indicate intra-day variability and different
indexes of GV should be used, depending on the metabolic profile of the population studied
and the specific issue to be investigated. Self glucose monitoring or continuous glucose monitoring
should be used for assessing glucose variability
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
John F. Kennedy telegram to Roosevelt
No full textJersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe. President John F. Kennedy sent a telegram to the citizens of Roosevelt, New Jersey, apologizing for not being able to attend the memorial dedication in honor of former President Franklin Delano Roosevelt. (Jersey Homesteads became Roosevelt in 1945 in honor of the president.) President Kennedy expressed his gratitude to the people of Roosevelt for constructing the memorial, and commented that it will serve as a constant reminder of Roosevelt's good works
Logarithmic variance profiles and the corresponding f-1 spectra of temperature fluctuations in turbulent Rayleigh-Bénard convection
No full textWe report experimental results for the temperature variance 2(z) and the corresponding frequency spectra P(f) in turbulent Rayleigh-Bénard convection (RBC) in a cylindrical sample of aspect ratioT= D/L = 1:00 (D = 1:12 m is the diameter and L = 1:12 m the height). The measurements were conducted in the Rayleigh-number range 1011 < Ra < 1:35 1014 and Pr ' 0:8. For Ra = 1:35x1014, 2(z) could be described well by a logarithmic dependence on the vertical position z in a range of z 1 < z < z 2 with z 1 ' 70 and z 2 = 0:1L. Here L=(2Nu) is the thickness of a thin thermal sublayer adjacent to the horizontal plate where the heat flux (denoted by the Nusselt number Nu) is carried mostly by thermal diffusion. In the log layer, we found that the temperature spectra had a significant frequency range over which P(f) f with close to 1. As Ra decreased, increased so that the log layer became thinner. At Ra = 2:05 1011, z 2 < z 1 and therefore there was no range for a log layer. Correspondingly, the temperature spectrum near the horizontal plate did not have the f1 scaling form either
Maine author Franklin F. Gould recalls his first glimpse of the outside world
No full textMaine author Franklin F. Gould recalls his first glimpse of the outside world as he relates how, as a young farm boy in the late 1800\u27s, he drove his father\u27s horses on an errand to an icebound river
Mapping the Discipline of the Olympic Games An Author-Cocitation Analysis
No full textThe authors conducted an author cocitation analysis on prominent authors writing about the Olympics during the 1990s. Author cocitation is an established bibliometric technique that can be used to measure the relative similarities of topics written about by the cited authors. This enables a visual representation of the “intellectual space” of the discipline, in this case the Olympics, to be created for the period under review. So core and peripheral research areas are identified, along with their major contributors. The representation appears as a two-dimensional cluster-enhanced map. Subject expertise was then applied to the results to place labels on the generated clusters of authors and their topics
Acute caloric restriction improves glomerular filtration rate in patients with morbid obesity and type 2 diabetes
No full textThe role of caloric restriction in the improvement of renal function following bariatric surgery is still unclear; with some evidence showing that calorie restriction can reduce proteinuria. However, data on the impact of caloric restriction on renal function are still lacking
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