163,853 research outputs found
Dearest Ellen! dearest Ellen! I'll love you no more! [first line of chorus]
No full textstrophic with choruspiano and voiceJohns Hopkins University, Levy Sheet Music Collection, Box
115, Item 181Words by E.J.B. Fitzsimons, Esqr. Music by Sir J. Stevenson, Mus. Doc.Engraved by T. Birc
Dearest Ellen! dearest Ellen! I'll love you no more! [first line of chorus]
No full textstrophic with choruspiano and voiceJohns Hopkins University, Levy Sheet Music Collection, Box
115, Item 181Words by E.J.B. Fitzsimons, Esqr. Music by Sir J. Stevenson, Mus. Doc.Engraved by T. Birc
Thirst
No full text J. T. Fitzsimons, “Thirst,” vol. 52, no. 2, April 1972, p. 481, line 6, the formula should read: [See PDF for Equation] </jats:p
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
HuettelSupplementalMaterial – Supplemental material for Indulgent Foods Can Paradoxically Promote Disciplined Dietary Choices
No full textSupplemental material, HuettelSupplementalMaterial for Indulgent Foods Can Paradoxically Promote Disciplined Dietary Choices by Nicolette J. Sullivan, Gavan J. Fitzsimons, Michael L. Platt and Scott A. Huettel in Psychological Science</p
HuettelOpenPracticesDisclosure – Supplemental material for Indulgent Foods Can Paradoxically Promote Disciplined Dietary Choices
No full textSupplemental material, HuettelOpenPracticesDisclosure for Indulgent Foods Can Paradoxically Promote Disciplined Dietary Choices by Nicolette J. Sullivan, Gavan J. Fitzsimons, Michael L. Platt and Scott A. Huettel in Psychological Science</p
Suppressors of cytokine signalling (SOCS) 2 and 3 diametrically control macrophage polarisation
No full textSuppressors of cytokine signalling (SOCS) 2 and 3 diametrically
control macrophage polarisation
S. Spence,* A. Fitzsimons,* C. Boyd,* J. Kessler,* D. Fitzgerald,*
J. Elliott,* J. Ni Gabhann, S. Smith, A. Sica, E. Hams,§
S. P. Saunders,§ C. Jefferies, P. Fallon,§ D. Mcauley,*
A. Kissenpfennig* & J. Johnston*
*Queen’s University Belfast, Belfast, UK, Royal College of Surgeons in
Ireland, Dubin, Ireland, Instituto Clinca Humanitas, Milan, Italy,
§Trinity College Dublin, Dublin, Ireland
M1 macrophages, induced by pro-inflammatory stimuli, and involved
in the acute response. M2 macrophages are polarised by anti-inflammatory
stimuli and mainly involved in healing. The Suppressors of
cytokine signalling (SOCS) are important regulators of both LPS and
cytokine responses but their role in macrophage polarisation is unknown.
Myeloid restricted SOCS3 deletion (SOCS3LysMcre) resulted
in profound resistance to endotoxic shock, whereas SOCS2)/) mice
were highly susceptible. This was associated with striking bias towards
M2-like macrophages in SOCS3LysMcre mice, whereas the M1-like
population was enriched in SOCS2)/) mice. Through adoptive
transfer experiments we show that these antipodal responses to endotoxic
shock and to polymicrobial sepsis (caecal ligation puncture)
were both transferable and entirely macrophage-dependent. Critically
this dichotomous response was associated with enhanced T-reg recruitment
by SOCS3)/) cells, yet in the presence of SOCS2)/)
macrophages, Foxp3+ T cells were completely absent at the inflammatory
site. The altered polarisation coincided with enhanced
IFNc- induced STAT1 in SOCS2)/) macrophages and enhanced IL-4/
IL-13 induced STAT6 phosphorylation in SOCS3)/) cells corresponding
to altered binding to traditional gene markers of M1 and M2
macrophages (iNOS, TNFa, ARG-1 and CCL-17,). In the absence of
SOCS2, macrophages seem unable to elicit an anti- inflammatory response
even when stimulated with typical M2 stimulus (IL-4/IL-13, IL-
10), whilst the absence of SOCS3 prevents a pro-inflammatory response
even in the presence of LPS/IFNc. Interestingly, the polarisation
of macrophages in the absence of SOCS2 or SOCS3 seems fixed and
irreversible. Therefore SOCS are essential controllers of macrophage
polarisation and regulate the inflammatory response
publications PAVE sur la recherche dans les ENSA
No full textTéléchargez ici le dernier numéro de la revue Culture et Recherche (Ministère de la Culture) dédié aux pratiques plurielles de la recherche en architecture (n°138 - hiver 2018). Parmi les articles de ce numéro figurent : "Mobilités durables et énergie. Recherche et innovation pédagogique" de J. Kent Fitzsimons "Architectes, les voies du changement" de Laura Rosenbaum (Brown) et Guy Tapi
sj-pdf-1-mrj-10.1177_00222437231184830 - Supplemental material for Sharing Food Can Backfire: When Healthy Choices for Children Lead Parents to Make Unhealthy Choices for Themselves
No full textSupplemental material, sj-pdf-1-mrj-10.1177_00222437231184830 for Sharing Food Can Backfire: When Healthy Choices for Children Lead Parents to Make Unhealthy Choices for Themselves by Kelley Gullo Wight, Peggy J. Liu, Lingrui Zhou and Gavan J. Fitzsimons in Journal of Marketing Research</p
- …
