3,676 research outputs found
Letter from Patrick M. Duignan to Hagan
No full textHolograph letter from Patrick M. Duignan, Summer Hill College Sligo, to Hagan. At the wish of the bishop, enclosing three documents of correspondence between the O'Conor Don, Clonalis, Castlerea, County Roscommon, and Bishop Bernard Coyne, St. Mary's, Sligo: the O'Conor Don recommends his friend Fr. Roche, now of St. John's Church, Brentford, London, for the rectorship at the Irish College. He has good command of Italian (marginal comment 'no Irish!') and is a 'kind zealous and polished priest'. The bishop replies that the present vice-rector �'a distinguished writer and author'- has a prior claim; the O'Conor Don concurs. Duignan offers himself as a potential vice-rector; asking for frank reply. Musing that the bishop's interest in the matter is surprising; he is intolerant of English interference and whole-heartedly supports Hagan
Art, Biography, Sexuality: Patrick Procktor and Keith Vaughan
No full textThis critical review forms a reflection on the research published within the following publications:
Patrick Procktor: Art and Life (Unicorn Press, 2010)
Keith Vaughan: The Mature Oils 1946-1977, (Sansom & Co., 2012)
The research is on two artists, Patrick Procktor (1936-2003), and Keith Vaughan (1912-1977). The monograph on Procktor – previously one of the least documented of the generation of artists who came to prominence in London in the Sixties – positions him in a history of art from which he had been notably absent. The research on Vaughan asserts a new reading of his work, one that is both deeper and more nuanced in its analysis of the ways in which personal experience and sexuality are encoded autobiographically within his work. Crucially, in both artists biography and work are symbiotically linked; the research therefore examines the links between life and art.
Revisionary in intent, the work examines trajectories of experience of gay British (or rather, English) artists in the twentieth century, artists who sought to express themselves and forge careers within the constraints of a heteronormative society, albeit one in which attitudes to sexuality were undergoing change. As gay men, both were constrained by the social mores of their times, and each used painting as a means to affirm personal and sexual identities. A key research interest is in the ways in which sexuality and persona are reflected in critical responses to the artist’s work: in Vaughan, Procktor and other gay male artists of the period. The writing on both Procktor and Vaughan examines the relationship between their personal and professional/artistic lives, framed within a broader socio-political and art historical context. It asserts the place of biography as a means to understand and form new readings of the work. The work adds substantially to the literature and wider discourse on post-war British painting and social history
Postfazione. Utopia e speranza: Bologna per Patrick Zaki
No full textThe essay elaborates on the talk the author delivered during the ceremony that took place after the liberation from prison of the UNIBO and honorary citizen of Bologna, Patrick Zaki. The essay elaborates on the following issues: the support of the university and city, the value of human rights, academic freedom, and public squares as spaces of democracy. It includes a longer part on utopia (as a literary genre and a political instrument of change) and hope, quoting academic scholars (Karl Mannheim, Ernst Bloch, Ursula Le Guin, Antonio Gramsci, Howard Zinn) and it explains the function of hope in utopia
Studies of the chemical and regulatory mechanisms of tyrosine hydroxylase
No full textTyrosine hydroxylase (TyrH) catalyzes the pterin-dependent hydroxylation of
tyrosine to form dihydroxyphenylalanine. The enzyme requires one atom of ferrous iron
for activity. Using deuterated 4-methylphenylalanine substrates, intrinsic primary and
secondary isotope effects of 9.6 ���� 0.9 and 1.21 ���� 0.08 have been determined for benzylic
hydroxylation catalyzed by TyrH. The large, normal secondary isotope effect is
consistent with a mechanism involving hydrogen atom abstraction to generate a radical
intermediate. The similarity of the isotope effects to those measured for benzylic
hydroxylation catalyzed by cytochrome P-450 suggests that a high-valent, ferryl-oxo
species is the hydroxylating species in TyrH. Uncoupled mutant forms of TyrH have
been utilized to unmask isotope effects on steps in the aromatic hydroxylation pathway
which also implicate a ferryl-oxo intermediate. Inverse secondary isotope effects were
seen when 3,5-2H2-tyrosine was used as a substrate for several mutant enzyme forms.
This result is consistent with a direct attack by a ferryl-oxo species on the aromatic ring
of tyrosine forming a cationic intermediate. Rapid-freeze quench M����ssbauer studies have provided preliminary spectroscopic evidence for an Fe(IV) intermediate in the reaction
catalyzed by TyrH.
The role of the iron atom in the regulatory mechanism has also been investigated.
The iron atom in TyrH, as isolated, is in the ferric form and must be reduced for activity.
The iron can be reduced by a number of one-electron reductants including
tetrahydrobiopterin, ascorbate, and glutathione; however, it appears that BH4 (kred = 2.8 ����
0.1 mM-1 s-1) is the most likely candidate for reducing the enzyme in vivo. A one-electron
transfer would require a pterin radical. Rapid-freeze quench EPR experiments aimed at
detecting the intermediate were unsuccessful, suggesting that it decays very rapidly by
reducing another equivalent of enzyme. The active Fe(II) form can also become oxidized
by oxygen (210 ���� 30 M-1 s-1); this increases the affinity of catecholamine inhibitors.
Serine 40 can be phosphorylated to relieve the inhibition; however, results with S40E
TyrH show phosphorylation does not have an effect on the rate constant for reduction of
the enzyme but causes a 40% decrease in the rate constant of oxidation
Spectral flow and bifurcation of critical points of strongly indefinite functionals I
No full textSpectral flow is a well-known homotopy invariant of paths of self-adjoint Fredholm operators. We describe here a new construction of this invariant and prove the following theorem: Let f : I × U -> R be a C2 function defined on the product of a real interval I = [a, b] with a neighborhood U of the origin of a real separable Hilbert space H and such that for each t in I, 0 is a critical point of the functional f (t, ·). Assume that the Hessian L of f at 0 is Fredholm and moreover that L_a and L_b are nonsingular. If the spectral flow of the path L does not vanish, then the interval I contains at least one bifurcation point from the trivial branch for solutions of the equation Grad f (t, x) = 0. Equivalently: every neighborhood of I × {0} contains points of the form (t,x) where x is a critical point of f_t different from 0
Pedo-geophysics teaching and research in the Adelaide hills
No full textPlease see page 6 of PDF for this item.Graham Heinson, Nick Direen, Mark Thomas, Andrew Baker, Rob Fitzpatrick, Patrick James, Brendan Coleman, Matthew Hutchens, Hashim Carey and the 3rd year Mineral and Environmental Geophysics Clas
M. Patrick Graham & Steven L. McKenzie (ed.), The Chronicler as Author. Studies in Text and Texture, Sheffield, Sheffield Academic Press, 1999, (Journal for the Study of the Old Testament, Supplement Series, 263), ISBN 1-84127-057-1
No full textRobert Philippe de. M. Patrick Graham & Steven L. McKenzie (ed.), The Chronicler as Author. Studies in Text and Texture, Sheffield, Sheffield Academic Press, 1999, (Journal for the Study of the Old Testament, Supplement Series, 263), ISBN 1-84127-057-1. In: Revue d'histoire et de philosophie religieuses, 80e année n°2, Avril-juin 2000. p. 297
A numerical study of mesoscale convection in a rotating tropical atmosphere
No full textDue to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references.Not availabl
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
"The honor of firing before His Majesty": Patrick Ferguson's will and the Royal Armouries’ Ferguson rifle
No full textPatrick Ferguson (1744-80) designed the first breech-loading rifle to be used by the British Army. In November 2000, the Royal Armouries purchased an early example, formerly in the possession of the Fergusons of Pitfour, descendants of Patrick's younger brother, George. Patrick Ferguson's will has helped the author identify the Royal Armouries' Ferguson Rifle as the one which Patrick Ferguson used when he demonstrated it before George III and Queen Charlotte at Windsor in 1776
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