168,377 research outputs found
WHAT WE KNOW ABOUT LIFE IS NOT EVEN A DROP OF WATER!
No full textIn the past twenty-five years, early biological concepts based on reductionist inference have been largely revisited and overshadowed by more recent molecular and pathogenetic findings, creating a brand new cultural approach. One of the most impressive discoveries was the ability of water to induce biological activity of specific substances to emit electromagnetic waves and to capture it. In July 2005, Luc Montagnier’s team discovered that new property of DNA: the induction of electromagnetic waves in water dilutions. As a matter of fact, water can serve as both the inductor and the template for the synthesis of specific DNA sequence by PCR [1]. In December 2012, by using double-blind encoding protocol, the principle of DNA biological activity on aqueous systems electronic transmission was replicated by the molecular biology laboratory of the University of Benevento, Italy. By receiving a data transmission from Montagnier’s laboratory in Paris region, a new copy of original DNA was synthesized by PCR. The final result was validated and confirmed by a third independent laboratory (UNESCO): the original and the transduced DNA sequences were nearly completely identical [2]. Incredibly small groups of atoms, much too small to display exact statistical laws, do play a dominating role and have control of the observable large-scale characteristics of organism functioning; and in all this very sharp and very strict biophysical and biological laws are displayed. They cannot be modelled by neither traditional nor more advanced statistical approach (Science 1.0 approach) alone [3]. To grasp a more reliable representation of reality and to get stronger biological and physical system correlates, researchers and scientists need the courage to raise the traditional statistical veil. We need a new, fresh "Science 2.0" approach [3]. To get stronger solution to advanced multiscale biophysics modelling problems, like clustered water characterization, biological activity of specific substances on aqueous systems modelling, etc., we have to look for convenient bottom-up modelling (from discrete to continuum, under the “discreteness hypothesis”) approach to start from first, and NOT the other way around. We need to extend our computational and systemic tools to overcome the information double-bind (IDB) dilemma first [4] and then to develop more effective and competitive modelling framework [3]. New computational information conservation theory (CICT) can offer computational earth-shaking solution to it [4]. A few examples are presented and discussed.
[1] Montagnier L, Aissa J, Del Giudice E, Lavallee C, Tedeschi A and Vitiello G. DNA waves and water. Journal of Physics: Conferences Series, 306: 012007, 2011. [2] Water Memory (Documentary of 2014 about Nobel Prize laureate Luc Montagnier. Retrieved on July 26, 2016 from: https://www.youtube.com/watch?v=R8VyUsVOic0. [3] Fiorini RA, Arbitrary multi-scale (AMS) systems biology and biomedical engineering effective modeling and simulation, Int. J. Biol. Biomed. Eng., Vol. 10, pp. 61-71, 2016. [4] Fiorini RA, The Information Double Bind (IDB) Problem in Current Science, 15th IEEE International Conference on Cognitive Informatics and Cognitive Computing, plenary panel, August 22-23, 2016, Stanford University, CA, USA
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Il ballo
No full textTraduzione del saggio di J. Lotman, inedito in Italia, intitolato "il ballo" , tratto dalle "Conversazioni sulla cultura russa". Traduzione ed introduzione di Cinzia De Lott
A systematic review on drugs absorption modifications after eradication in Helicobacter pylori positive patients undergoing replacement therapy
No full textBackground & Aims: Helicobacter pylori (H. pylori) infection has been suggested as a cause of impaired drug absorption. This infection leads to alteration of the gastric acid secretion that may change the conformational characteristics of drugs and their intestinal absorption leading to uncertainties about the dose to administer and the therapeutic results. A systematic review was undertaken to clarify the implications of drug absorption during the administration of replacement therapies.
Methods: Electronic databases such as MEDLINE/Pubmed, EMBASE and The Cochrane Library [which includes Cochrane Database of Systematic Review (CDSR), the Cochrane Central Register of Controlled Trials (CENTRAL), the Database of Abstract of Reviews of Effect (DARE)] were searched. Grey literature databases (e.g. the International clinical trials registry platform, Trials Register, Clinical Trials.gov, Controlled Trials and TrialsCentral), Theses database, Government publication and LILACS database were also searched. No language restriction was applied.
Results: Infection and altered drug absorption were evaluated in patients under replacement therapies with iron, thyroxin and L-dopa. In all, seven studies included an improvement in drug absorption after eradication and an existing inverse correlation between the grade of gastric inflammation and indices of drug absorption were noticed.
Conclusion: This systematic review confirmed the presence of an interaction between infection and drug absorption of orally administered replacement therapies. Gastric acid reduction and subsequent alteration of drug composition seem to lead this mechanism. Clinicians should be aware of this possible interaction when starting a replacement therapy in patients and when evaluating poor clinical respons
Gli 1,3-Dinitroalcani Come Immediati Precursori di Sistemi Aromatici
No full textI nitroalcani primari e secondari hanno da tempo dimostrato di essere una delle classi di composti più convenienti nella generazione di carbanioni stabilizzati e, quindi, nella formazione di nuovi legami C,C, semplici e doppi.1,2 Inoltre, la capacità della funzionalità nitro di poter contemporaneamente agire da forte gruppo elettron-attrattore e da ottimo gruppo uscente3 ha permesso, nel recente passato, di poter arrivare alla sintesi “one pot” di sistemi aromatici a partire da nitroalcani (Schema 1).
Continuando nello studio dell’applicazione dei nitroderivati nella sintesi di sistemi benzenici, abbiamo ora trovato che attraverso gli 1,3-dinitroalcani è possibile ottenere una serie di benzeni polialchilati e polifunzionalizzati, molto difficili da ottenere per altra via (Schema 2).
Risultati e condizioni di reazione verranno riportati.
1 G, Rosini In Comprehensive Organic Synthesis; B. M. Trost, Ed.; Pergamon: Oxford, 1991, Vol. 2, p. 321.
2 R. Ballini, G. Bosica, D. Fiorini, A. Palmieri, M. Petrini Chem. Rev. 2005, 105, 933.
3 R. Ballini, A. Rinaldi Tetrahedron Lett. 1994, 35, 9247.
4 (a) R. Ballini, L. Barboni, G. Bosica J. Org. Chem. 2000, 65, 6261. (b) R. Ballini, L. Barboni, G. Giarlo, D. Fiorini, A. Palmieri Chem. Commun. In press
Minimalist Jumping Robots for Celestial Exploration
No full textIn this paper we describe a novel approach to the design and deployment of small and minimally actuated jumping or hopping robots that are suitable for exploring the unstructured terrains of celestial bodies. We introduce the basic jumping mobility paradigm, as well as the evolution of our hopping robot concept by way of the main prototypes that we have developed. These prototypes show that a small number of actuators can control the vehicle's steering, hopping, and self-righting motions. The last prototype is equipped with wheels so that precision motion can be combined with gross hopping motion. Lessons learned during the development of these prototypes have general applicability to the design of jumping robots. In addition to reviewing the issues relevant to the design of jumping systems, in this paper we describe some of the key mechanisms that enable our approach, we summarize tests obtained with these systems, and we present our future plans of localization and sensing for hopping mobility
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
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