196,436 research outputs found
Prefazione a "I volti del principe"
No full textNon la democrazia ma la tirannide è spesso il termine opposto al principato nella civiltà premoderna. Una semantica storica è dunque necessaria per non proiettare i nostri schemi ideologici sull'epoca post-comunale, recuperando invece le ragioni culturali e civili che spingono umanisti come Petrarca a celebrare un principato antitirannico sullo sfondo di memorie classiche (in particolare liviane) e sulla base di una rilettura militante dell'antico
Petrarca: l'invenzione del principe umanista
No full textCome si concilia il classicismo repubblicano e comunale con l'apertura verso un orizzonte principesco nell'Italia delle Signorie? E qual è la relazione tra sovranità principesca e sovranità intellettuale? Proprio nell'affrontare le due questioni, Petrarca dimostra la propria straordinaria lucidità politica, e la capacità di influenzare durevolmente la fisionomia del principe nell'Europa delle Corti
Una proposta per la valutazione interna dei nuovi percorsi universitari
No full textIl lavoro presenta la sperimentazione di uno strumento volto a valutare, nel contesto di alcuni corsi di laurea di recente istituzione, i risultati della Riforma dell'università del 1997, in termini di miglioramento della qualità della didattica e dei servizi erogati. L'idea guida è che la valutazione di un progetto formativo non possa esaurirsi nel considerare la didattica erogata dai singoli docenti, ma che occorra realizzare un approccio d’insieme che sappia coglierne la congruenza complessiva. La rilevazione del punto di vista degli studenti con un questionario di fine anno ha cercato di compendiare valutazioni su aspetti didattici e organizzativi. I risultati hanno fornito importanti indicazioni circa i punti di forza e di debolezza dei percorsi formativi. Il piano complessivo di monitoraggio deve comunque ampliare il suo orizzonte su altre dimensioni d'interesse, quali il punto di vista degli altri attori interessati, e soprattutto considerare gli outcome formativi e occupazionali dei corsi di laurea
Possible effects of sirolimus treatment on the long‐term efficacy of COVID‐19 vaccination in patients with β‐thalassemia: A theoretical perspective
No full textThe pandemic caused by the severe acute respiratory syndrome coronavirus (SARS‐CoV‐2), responsible for coronavirus disease 2019 (COVID‐19) has posed a major challenge for global health. In order to successfully combat SARS‐CoV‐2, the development of effective COVID‐19 vaccines is crucial. In this context, recent studies have highlighted a high COVID‐19 mortality rate in patients affected by β‐thalassemia, probably due to their co‐existent immune deficiencies. In addition to a role in the severity of SARS‐CoV‐2 infection and in the mortality rate of COVID‐19‐infected patients with thalassemia, immunosuppression is expected to deeply affect the effectivity of anti‐COVID‐19 vaccines. In the context of the interplay between thalassemia‐associated immunosuppression and the effectiveness of COVID‐19 vaccines, the employment of immunomodulatory molecules is hypothesized. For instance, short‐term treatment with mammalian target of rapamycin inhibitors (such as everolimus and sirolimus) has been found to improve responses to influenza vaccination in adults, with benefits possibly persisting for a year following treatment. Recently, sirolimus has been considered for the therapy of hemoglobinopathies (including β‐thalassemia). Sirolimus induces the expression of fetal hemoglobin (and this may contribute to the amelioration of the clinical parameters of patients with β‐thalassemia) and induces autophagy (thereby reducing the excessive levels of α‐globin). It may also finally contribute to the mobilization of erythroid cells from the bone marrow (thereby reducing anemia). In the present study, the authors present the hypothesis that sirolimus treatment, in addition to its beneficial effects on erythroid‐related parameters, may play a crucial role in sustaining the effects of COVID‐19 vaccination in patients with β‐thalassemia. This hypothesis is based on several publications demonstrating the effects of sirolimus treatment on the immune system
La flussimetria doppler nella valutazione pre e post operatoria del varicocele essenziale
No full textTesting Bayesian Informative Hypotheses in Five Steps With JASP and R
No full textOne of the most common applications of Bayes's theorem for inferential purposes consists of computing the ratio between the probability of the alternative and the null hypotheses via a Bayes factor, which allows quantifying the most likely explanation of the data between the two. However, the actual scientific questions that researchers are interested in are rarely well represented by the classically defined alternative and null hypotheses. Bayesian informative-hypothesis testing offers a valid and easy way to overcome such limitations via a model-selection procedure that allows comparing highly specific hypotheses formulated in terms of equality (A = B) or inequality (A > B) constraints among parameters. Although packages for testing informative hypotheses in the most used statistical software have been developed in recent years, they are still rarely used, possibly because their implementation and interpretation may not be straightforward. Starting from a brief theoretical overview of the Bayesian theorem and its applications in statistical inference (i.e., Bayes factor and Bayesian informative hypotheses), in this article, we provide two step-by-step tutorials illustrating how to test, interpret, and report in a scientific article Bayesian informative hypotheses using JASP and R/RStudio software for running a 2 x 2 analysis of variance and a multiple linear regression. The complete JASP files, R code, and data sets used in the article are freely available on the OSF page at https://osf.io/dez9b/
Donne, sogni e fantasmi in Antonio Fogazzaro
No full textA partire da "Malombra" Fogazzaro sposta in ambito psicologico (e si direbbe proto-psicanalitico) le tematiche e i luoghi comuni di tanta letteratura gotica e spiritistica: non dall'oltremondo vengono i fanstasmi ma dalla psiche, dalla forza di impulsi non dominati dalla volontà, dall'azione del sogno, dalla crisi della coscienza razionale. L'attenzione vivissima di Fogazzaro alla psicologia del profondo è confermata dal discorso "Per una nuova scienza", dove si propongono ricerche che saranno poi importanti per Pirandello. I romanzi della maturità rappresentano un'estensione della tematica che in "Malombra" è collegata alla psicologia d'eccezione della protagonista. Impulsi, pensieri, sintomi inconsci nei successivi romanzi fogazzariani travolgono anche personaggi che vorrebbero aggrapparsi ostinatamente alla normalità, dando così all'autore la possibilità di rappresentare con efficacia sia la dialettica tra rimozione e ritorno sulla quale si soffermerà Freud, sia la relazione tra pensiero e corporeità
One-lung ventilation to treat hepatic dome lesion - A further step towards minimally invasive surgery: A case report
No full textBackground: Although liver resection is still the best treatment for primary or metastatic hepatic lesions, a conventional surgical approach may be challenging in patients with a history of previous abdominal surgery. We present a case of a 58-year-old white man with paracaval, subdiaphragmatic, recurrent hepatocellular carcinoma; he had a history of multiple abdominal surgeries. Methods: In select patients, percutaneous ultrasound-guided thermal ablation is a valid non-surgical alternative due to its safety, efficacy, and good tolerability. Hepatic lesions located in the posterosuperior segments, however, can be difficult to reach via a percutaneous approach. Result: For these cases, one-lung left-sided ventilation may be particularly helpful in blocking the right hemidiaphragm and improving the acoustic window to the liver. Conclusion: We present a case of paracaval, subdiaphragmatic, recurrent hepatocellular carcinoma in which the tumor was only reachable after one-lung left-sided ventilation that was successfully treated by percutaneous ultrasound-guided microwave ablation. © 2019 The Author(s)
Ultra sensitive plasmonic devices for early cancer diagnosis
No full textULTRAPLACAD aims at the development of a novel robust in vitro diagnostic system for early cancer
diagnosis, prognosis, patient follow-up and therapy efficacy assessment based on molecular analysis
of peripheral blood (liquid biopsy). Although the platform may find wide applications in oncology,
ULTRAPLACAD will focus solely on colorectal cancer (CRC) that is the second most frequently occurring
cancer in the EU with an equal distribution among women and men. ULTRAPLACAD will provide
unique and up to now not existing platform for the comprehensive detection of nucleic acids and protein
CRC biomarkers in blood plasma.
The extremely low concentration of most cancer biomarkers in blood imposes a stringent barrier to the wide
applicability of the liquid biopsy for CRC diagnosis. The ULTRAPLACAD will deliver a disruptive
diagnostic platform for the analysis of cancer biomarkers in blood plasma with unprecedented
sensitivity and reliability. Reaching ULTRAPLACAD goals will significantly contribute to wider spread of
diagnostic and prognostic protocols based on liquid biopsy – an emerging and rapidly developing cancer
diagnostic approach.
The use of innovative optical analytical techniques that take advantage of plasmonic metallic
nanostructures (nanostructure-enhanced surface plasmon resonance imaging -NESPRI – and plasmonenhanced
fluorescence spectroscopy imaging – PEFSI) will advance the state-of-art of CRC biomarkers
detection (Figure 1)
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