1,720,984 research outputs found
Persistence of superficial basal cell carcinoma during pembrolizumab treatment for metastatic melanoma
No full textTopical propranolol for a chronic recalcitrant wound
No full textA 68 year‐old patient presented to our attention with a deep ulcerating lesion of the right sole.
He reported the substance loss had manifested after a corticosteroid infiltration at the same site for anti‐inflammatory purposes about 11 months before. He reported no other medical condition.
At physical examination a 2 × 1 cm ulcer was present, with irregular and undermined borders. The substance loss involved completely the skin and the subcutaneous tissue, sparing the plantar fascia which was left exposed (FIG. 1). No sign of infection was noticeable. The lesion had been treated with a variety of topical and systemic drugs, including advanced dressings, dermal substitute (Integra), and subcutaneous low molecular weight heparin as well as aspirin, with no significant clinical response whatsoever. At time of consultation, vacuum‐assisted closure therapy was proposed, but the patient refused. Based on various reports on successful use of topical timolol for chronic ulcers, we discussed the possibility of using a similar off‐label treatment. With written consent, we started the patient on a three times/day topical application of a galenic preparation of 1% propranolol‐hydrochloride in a hydrophilic cream, covered by a nonadhering silicone dressing (Adaptic) while withdrawing any other specific treatment. We chose propranolol instead of timolol for the excellent safety profile and minor systemic absorption, as supported by the vast experience on ulcerated infantile hemangiomas 1. After 3 weeks of continued application, the ulcer had dramatically improved, and after another week the lesion had completely healed (FIG. 2). No irritation or other local or systemic adverse effects were noticed. The cream was then suspended; follow up at 1 year did not show any sign of recurrenc
An inexpensive wound closure strip
No full textThe use of adhesive suture strips after placement of buried and subcuticular sutures is commonly accepted as
a means to further reduce wound tension, approximate the wound edges, and protect wounds from external
environmental factors such as microbiological contamination. However, such devices are not always readily
available and have a relatively high cost depending on wound length (even more so when placed over skin
glues) and their use can be time consuming
A single black ulcer in a child with acute lymphocytic leukemia
Full text linkEcthyma gangrenosum is an uncommon dermatological manifestation characterized by round, indurated ulcers with a central necrotic black eschar and surrounding erythema. This report describes the case of a 5-year-old girl, affected by acute lymphocytic leukemia, presenting with a black eschar on her right thigh. Such lesions should always be correctly identified to avoid potentially fatal bacteraemia. Furthermore, because of its similar clinical presentation, cutaneous anthrax must be ruled out
Acute urethritis and balonoposthitis associated to Neisseria elongate
No full texta case of a 39-year-old man
who presented at the sexually transmitted
disease outpatient service of our
Dermatology Unit with a frank acute purulent
balonoposthitis and urethral discharge
Cutaneous mastocytosis and infantile hemangioma. Only a coincidence?
No full textThis work considers a possible clinical correlation between hemangiomas and mastocytosis in 5
patients.
Retrospectively, we analyzed 96 patients with CM, consecutively observed between November
2008 and April 2017. Among them, 5 children were also affected by cutaneous hemangioma
(Figure 1).
Clinical characteristics of patients with cutaneous hemangioma and mastocytosis were collected, as
well as pregnancy and maternal history
Recurrent cutaneous leiomyosarcoma of the inner thigh
Full text linkA 55-year-old African male from Senegal presented
with a large nodular lesion on the inner surface of
the left thig
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