1,721,331 research outputs found
First Congress of the Italian Society for Safety and Quality in Transplantation. Preface
No full textNo abstract availabl
Clinical practice and the use of resources in the search for a new organizational ethic
No full textNo abstract availabl
The Italian Society for Safety and Quality in Transplantation (SISQT)
No full textThe Italian Society for Safety and Quality in Transplantation (La Societâ
Italiana per Ia Sicurezza e la Qualità nei Trapianti, SISQT) was founded in 2008
to bring quality and safety issues at the center of donation and transplantation
practice. In doing so, the SISQT seeks to involve, all health care professionals
across the continuum of donation and transplantation, championing a
collaborative, inclusive, inter-disciplinary, inter-professional, and
multi-stakeholder approach, in order to ease translation of the results of
research into clinical practice. The program of the SISQT aims to (1) set a
patient safety agenda with all professionals and stakeholders; (2) design and
implement patient-centered care processes and procedures; 3) help professionals
harmonize and integrate operational practice with policy and regulatory mandates
of the European union; (3) lay the scientific evidence on management of complex
care across the continuum of donation and transplantation; (4) promote behaviors
and cultural attributes in light of quality and safety. Accomplishment of these
results requires cooperation of each care provider at all levels, from hospital
to home to achieve integration of patient expectations within the scope of
current transplant practice
Animal models of fulminant hepatic failure: need to test liver support devices
No full textFulminant hepatic failure is one of the most dramatic entities in clinical medicine, but experimental studies of its pathogenesis, evolution and treatment have, so far been limited by the lack of satisfactory animal models for testing new supportive treatment options. The variable aetiology, complex pathogenetic mechanisms and inconstant clinical evolution of human fulminant hepatic failure make it particularly difficult to establish an "ideal fulminant hepatic failure animal model" suitable for all studies: it is no longer mandatory to develop one single model serving all possible scientific needs, but the use of a specific model for a specific issue is more advisable. The currently available animal models of fulminant hepatic failure are the hepatotoxic, surgical and combined hepatotoxic and surgical models. From a general point of view, surgical models may be particularly appropriate for studying the consequences of hepatic necrosis on cerebral oedema. The anhepatic model is very useful for validating new supportive measures to bridge the period between the onset of fulminant hepatic failure and the time at which a suitable organ becomes available and, despite the many difficulties involved in their development, hepatotoxic models may still be useful for mimicking an acetaminophen overdose. The efficacy and reproducibility of a liver support system can be demonstrated by means of preclinical experimental models that mimic the specific application required in humans as closely as possible
Increase of the mitotic activity of colonic mucosa in patients with multiple non-familial adenomatous polyps
No full textA histological study of colonic mucosa, including the measurement of the mitotic index, was performed in routinely processed specimens from control subjects and patients with multiple non-familial adenomatous polyps, to ascertain whether the onset of adenomatous polyps was accompanied by an increase in mucosal mitotic activity as compared with controls. The mitotic index of both the polyps and the mucosa 20 cm from the anal orifice of the same patients was significantly (P less than 0.01) higher than that of control 20 cm from the anal orifice and a shift of the mitotic activity from the lower two-thirds to the upper third of glands was observed in the polyps. These data suggest that an increase of mitotic activity in the superficial third of the glands as compared with controls plays a pathogenetic role in the onset of adenomatous polyps and that this phenomenon is accompanied by a diffuse increase of mitotic activity in the deeper two-thirds of the glands
Use of elderly donors in liver transplantation: a paired-match analysis at a single center
No full textAminopyrine breath test in cirrhotic patients awaiting liver transplantation: do we really need it ?
No full textNo abstract availabl
Interregional allocation models for liver transplantation
No full textIn light of the persistent donor scarcity, it has been advocated to shift the
current region-based allocation model for liver transplantation (OLT) to an
interregional one, so as to allow sicker patients on the wait list to obtain
timely transplantations. Being convinced that tackling the challenge of organ
donor scarcity requires appropriate measures, we have suggested some initiatives
to be taken at different levels. First, definition of the real need for OLT,
since it is largely unknown to transplant physicians and still represents the
starting line for any initiative in the field. Second, we recommend creation of
liver transplant care processes organized around the concept of smooth, seamless,
and prompt referral of liver disease patients. Third, we suggest continued
efforts in the field of deceased donation, so as to reduce the chasm between
organ donation and demand and limit the persistent variability among regions.
Fourth, we favor patient mobility, so as to expand the opportunity for
transplantation for sicker patients. Finally, we seek to improve the efficiency
of interregional coordination by prompt referral of extended criteria donors,
sicker patients, or patients with rare diseases, so as to expand the opportunity
for better donor-to-recipient matching at a national level
- …
