5,395 research outputs found
Targa d'Argento U.I.D. (Unione Italiana per il Disegno).
No full textIl premio è stato dato al contributo che Emanuela Chiavoni ha dato nell'analisi e nel rilevamento diretto, strumentale e fotogrammatrico della Sala dell'Oratorio dei Filippini, di Francesco Borromini in Roma.Il progetto di restituzione fotogrammetrica ha consentito di definire la genesi geometrica della volta della Sala dell'Oratorio e di fare confronti con i disegni esistenti
L'oratorio dei Filippini in Roma: disegni di progetto a confronto.
No full textSono stati analizzati e messi a confronto i disegni di progetto relativi all'Oratorio dei Filippini, opera seicentesca dell'architetto Francesco Borromini in Roma. La comparazione tra i diversi progetti ha consentito di fare ipotesi e riflessioni attente sull'opera barocc borrominiana
L'intervento pubblico nell'economia delle Regioni e degli enti locali, tra aiuti di Stato e tutela della concorrenza
No full text«Un esilio in patria»: l’impegno irredentista e fascista di Anton Francesco Filippini attraverso «L’Idea Còrsa»
No full textFrom the second half of the 1920s, some young Corsican irredentists left their island to settle in Italy: emigration? immigration? or even, beyond these two readings, a «fascist migration» materializing a «return to the sources», a sort of rimpatriata. This «esilio in patria» is embodied in the personality of Anton Francesco Filippini, one of the figures of the fascist networks of Corsican irredentism. The content of «L’Idea Còrsa», a periodical that he founded in Rome in 1942, illustrates the construction of a political discourse mixing these two ideologies
Pandemic Avian Influenza and Intra/Interhaemagglutinin Subtype Electrostatic Variation among Viruses Isolated from Avian, Mammalian, and Human Hosts
No full textHost jump can result in deadly pandemic events when avian influenza A viruses broaden their host specificity and become able to infect mammals, including humans. Haemagglutinin—the major capsid protein in influenza A viruses—is subjected to high rate mutations, of which several occur at its “head”: the receptor-binding domain that mediates specific binding to host cell receptors. Such surface-changing mutations may lead to antigenically novel influenza A viruses hence in pandemics by host jump and in vaccine escape by antigenic drift. Changes in haemagglutinin surface electrostatics have been recently associated with antigenic drift and with clades evolution and spreading in H5N1 and H9N2 viruses. We performed a comparative analysis of haemagglutinin surface electrostatics to investigate clustering and eventual fingerprints among representative pandemic (H5 and H7) and nonpandemic (H4 and H6) avian influenza viral subtypes. We observed preferential sorting of viruses isolated from mammalian/human hosts among these electrostatic clusters of a subtype; however, sorting was not “100% specific” to the different clusters. Therefore, electrostatic fingerprints can help in understanding, but they cannot explain alone the host jumping mechanism
Normal Modes Analysis and surface electrostatics of haemagglutinin proteins as fingerprints for high pathogenic type A influenza viruses
No full textBackground Type A influenza viruses circulate and spread among wild birds and mostly consist of low pathogenic strains. However, fast genome variation timely results in the insurgence of high pathogenic strains, which when infecting poultry birds may cause a million deaths and strong commercial damage. More importantly, the host shift may concern these viruses and sustained human-to-human transmission may result in a dangerous pandemic outbreak. Therefore, fingerprints specific to either low or high pathogenic strains may represent a very important tool for global surveillance. Results We combined Normal Modes Analysis and surface electrostatic analysis of a mixed strain dataset of influenza A virus haemagglutinins from high and low pathogenic strains in order to infer specific fingerprints. Normal Modes Analysis sorted the strains in two different, homogeneous clusters; sorting was independent on clades and specific instead to high vs low pathogenicity. A deeper analysis of fluctuations and flexibility regions unveiled a special role for the 110-helix region. Specific sorting was confirmed by surface electrostatics analysis, which further allowed to focus on regions and mechanisms possibly crucial to the low-to-high transition. Conclusions Evidence from previous work demonstrated that changes in surface electrostatics are associated with the evolution and spreading of avian influenza A virus clades, and seemingly involved also in the avian to mammalian host shift. This work shows that a combination of electrostatics and Normal Modes Analysis can also identify fingerprints specific to high and low pathogenicity. The possibility to predict which specific mutations may result in a shift to high pathogenicity may help in surveillance and vaccine development
I nuovi mostri: tra vecchie e nuove antibioticoresistenze nel nostro Paese
No full textinquadramento epidemiologico ed economico delle AM
L'intervento pubblico nell'economia delle Regioni e degli enti locali tra aiuti di Stato e tutela della concorrenza
No full textPlanning mm-Wave Access Networks Under Obstacle Blockages: A Reliability-Aware Approach
No full textMillimeter-wave (mm-wave) technologies are the main driver to deliver the multiple-Gbps promise in next-generation wireless access networks. However, the GHz-bandwidth potential must coexist with a harsh propagation environment. While strong attenuations can be compensated by directional antenna arrays, the severe impact of obstacle blockages can only be mitigated by smart resource allocation techniques. Multi-connectivity, as multiple mm-wave links from a mobile device to different base stations, is one of them. However, the higher reliability provided by several access alternatives can be fully exploited only if uncorrelated link statuses are guaranteed. Therefore, spatial diversity must be enforced. Moreover, since interposing obstacles can block a link, short access links allow reducing the link unavailability probability. Smart base-station selections can be made once the network is deployed, however, our results show that much better results are achievable if spatial diversity and link-length aspects are directly included in the network planning phase. In this article, we propose an mm-wave access network planning framework that considers base-station spatial diversity, link lengths, and achievable user throughput, according to channel conditions and network congestion. The comparison against traditional k-coverage approaches shows that our approach can obtain much better access reliability, thus providing higher robustness to random obstacles and self-blockage phenomena
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