5,177 research outputs found
Precision-scored parental report questions and HL-scaled tympanometry as informative measures of hearing in otitis media 1 : Large-sample evidence on determinants and complementarity to pure-tone audiometry
No full textIntroduction: In otitis media with effusion (OME), hearing loss is a core sign/symptom and basis of concern, with absolute pure-tone threshold sensitivity (in dB HL) by air-conduction providing the default measure of hearing. However several fundamental problems limiting the value of HL measures in otitis media are insufficiently appreciated. To appraise the joint value and implications of multiple hearing measures towards more comprehensive hearing assessment in OM, we examine in two related articles the interrelations and common or diverging determinants of three measures, two of them objective: binaural HL, and ACET (the published quasi-continuous scaling of binaural tympanometry to HL). The third measure is partly subjective: parentally reported hearing difficulties (RHD-4); this is the precision-scored total of the 4 items selected for the OM8-30 general purpose questionnaire for parents in OM. Methods: The Eurotitis-2 study (Total N = 2886) internationally standardises OM8-30 and its OMQ-14 short form. The clinical and parent-response variables acquired cover many issues in diagnosis, symptomatology and impact of OM. Data acquisition was built upon routine clinic practice, enabling us also to document some properties of that practice, such as patterns of missing HL data. To address possible confounding or loss of representativeness from this, we investigated the implications of substituting tympanometry-based ACET for missing HL to give an HL/ACET hybrid. ACET is the mapping of categorical tympanometry to continuous HL. We simulated degrees of artificial missingness of HL up to 35% on the 1430 complete-data cases, using random deletion, with 1000-version bootstrapping. Correlations of this HL/ACET hybrid with pure (100%) HL then documented the degree of correlation retained under dilution of HL by an admixture of ACET; we also documented distribution shapes. For RHD-4, we then probed the determining influences on severity of score as an auditory disability measure, both background ones (from centre, age, sex, socio-economic status, length of history, diagnosis and season) and the two underlying objective hearing measures (HL, ACET). We ran these multiple regressions (GLMs), for representativeness and generality, both on 1430 complete-data cases (i.e. all 3 hearing variables present) and also on supplemented samples according to data required only for particular analyses (N increased by +56% to +68%). A further method of sample supplementation (by up to +96%) used the HL/ACET hybrid. Results: Sex made negligible difference in any analysis. The particular collaborating centre, age, season and diagnosis collectively influenced presence/absence of HL data very strongly. (Area under ROC 0.944). Socio-economic status did not influence HL presence; surprisingly, nor did RHD, ACET or length of history, after control for centre, age, diagnosis and season. Of the inter-correlations between hearing measures, only the one between ACET and RHD was influenced (slightly reduced) by the inclusion of cases without HL data. In the simulated substitutions, Pearson correlation of hybrid HL/ACET with true HL remained above 0.90 for substitution by ACET of up to 30% rate of artificially 'missing' HL. Centre differences were adequately summarised by simple absolute additive differences in mean local case severity. In the determinant models for RHD on the 1430 complete-data cases, HL and the set of background determinants collectively explained broadly similar proportions of RHD's variability, totalling 36.8% explained. On the larger maximum case samples, slightly less absolute variability was explicable than on complete-case data, but relative magnitudes of contribution from individual determinants, both background and hearing measures, remained similar. The expected mean differences in RHD between diagnoses (RAOM, OME, and combined) were found, but the patterns of background and objective measure influences determining RHD did not differ significantly between the diagnoses. Conclusions: (1) In the Eurotitis-2 database, descriptive differences in various background demographic and clinical measures between cases on whom HL data were obtained versus not, were only of material magnitude for length of history and reported hearing difficulties. Such descriptive differences are not necessarily bases of confounding, so using our framework of 6 background adjuster variables, (particular collaborating centre, age, season, diagnosis, socioeconomic status and length of history) we isolated the determinants of HL data presence. The first four listed strongly predicted HL data presence/absence so are sufficient to control analyses well for any bias or confounding by HL data presence.(2) Diagnoses as OME and combined (OME + RAOM) had higher probability of HL data being present relative to RAOM, indicating that HL acquisition is chiefly seen as confirming and quantifying hearing loss in (suspect) OME, not as ruling it out (e.g. in suspected RAOM). Given this, also using RHD and or ACET as pre-triage to efficiently target capacity and/or reduce costs and opportunity costs of acquiring HL would be rational, but there was no evidence of such precise use of initial hearing-related information to decide on HL acquisition.(3) The full six background variables explained comparable variance in Reported Hearing Difficulties (RHD) to what was explained by ACET, but not quite as much as by HL. Achieving a high percentage explained (32-37% from good models) required both classes of determinant to be entered as predictors. The pattern of background determining influences for RHD was largely stable, with or without objective measures as additional predictors, and on maximum or complete-data cases. Length of history strongly determines RHD for a given concurrent HL.(4) Accepting ACET as substitute where HL was missing in OM cases gave a sample-size enhancement of 17% in Eurotitis-2, with negligible difference in the pattern of determinants. This hybrid measure can be recommended as reasonable next-best when moderate percentages of HL data are missing.(5) The stable pattern of prediction of RHD suggests that our six background determinants provide a very promising low-cost yet comprehensive framework for determination. It hence offers pluripotent statistical adjustment against confounding, applicable to RAOM, OME and combined diagnoses in any analysis using this database. Claims that it thereby offers a sufficient framework for full European standardisation of all the scores from the OM8-30 questionnaire measures await parallel demonstrations for symptom areas other than RHD. As 25% of the variance in RHD severity can be explained by the six adjusters in our framework, none of the six variables should be omitted from acquisition and analytic use in future OM research
Dredging Processes I: The Cutting of Sand, Clay & Rock - Theory
No full textThis book gives an overview of cutting theories. It starts with a generic model, which is valid for all types of soil (sand, clay and rock) after which the specifics of dry sand, water saturated sand, clay, rock and hyperbaric rock are covered. For each soil type small blade angles and large blade angles, resulting in a wedge in front of the blade, are discussed. The failure mechanism of sand, dry and water saturated, is the so called Shear Type. The failure mechanism of clay is the so called Flow Type, but under certain circumstances also the Curling Type and the Tear Type are possible. Rock will usually fail in a brittle way. This can be brittle tensile failure, the Tear Type, for small blade angles, but it can also be brittle shear failure, which is of the Shear Type of failure mechanism for larger blade angles. Under hyperbaric conditions rock may also fail in a more ductile way according to the Flow Type of failure mechanism. For each case considered, the equations/model for the cutting forces, power and specific energy are given. The models are verified with laboratory research, mainly at the Delft University of Technology, but also with data from literature.Marine & Transport TechnologyMechanical, Maritime and Materials Engineerin
Work among Japanese in the Salt River Valley of Arizona
No full textDocument written by S.A. Stewart Resident Missionary, East Kyushu Distict, Japan Methodist Church. Stewart discusses the events at the church and the free and restricted zones for Japanese Americans living in Glendale and Phoenix, Arizona.The Bishop James Chamberlain Baker Collection includes letters, documents, and articles about Japanese Americans during World War II. Subjects in the collection include Japanese Americans mass removal, Pearl Harbor and the aftermath, religion, and support from the non-Japanese American community. The collection was digitized and made accessible online by CSUDH Gerth Archives and Special Collections
TP S.A.) (Umowa spoleczna - narzedzie transformacji czy recepta na kryzys? (TP S.A.)
No full textThe author presents the path to the signing of a Social Contract for the years 2009-2011 by all eighteen trade unions active at 'Telekomunikacja Polska S.A. The Contract defines the most important elements of employment policy and worker development, including a plan for the restructuring of the company and voluntary resignation for compensation on the part of the employe
The mining rescure in SRK S.A. – economics and busines
No full textArtykuł podejmuje problematykę ratownictwa górniczego w Polsce w kontekście likwidowanych zakładów górniczych. Na podstawie wybranych przepisów górniczych autor wyjaśnia zasady funkcjonowania ratownictwa przedsiębiorcy i podmiotów zawodowo trudnią-cych się ratownictwem górniczym. Opisuje organizację ratownictwa górniczego w Polsce oraz kompetencje poszczególnych podmiotów w tym zakresie. Przedstawia także etapy tworzenia ratownictwa górniczego w spółce SRK S.A. oraz elementy analizy ekonomicznej związanej z kosztami utrzymania Stacji Ratownictwa Górniczego SRK S.A. Artykuł porusza również problem społeczny związany z próbą przejęcia przez Centralną Stację Ratownictwa Górniczego S.A. w Bytomiu pełni zabezpieczenia w zakresie ratownictwa górniczego 12 oddziałów SRK S.A. w których nadal prowadzone są roboty podziemne. W podsumowaniu autor opisuje paradoksy tego przedsięwzięcia.The article discusses aspect of the mining rescue in Poland in the context of liquidated mining plants. On the basis of selected mining regulations, the principles of the rescue operation of an operator as well as of professional mining rescue workers has been explained. This paper describes the organization of the mining rescue in Poland and the competences of individual entities included in this entity. Described have been also the stages of organizing the mining rescue in SRK S.A. and elements of economic analysis of maintenance costs in SRK S.A. Rescue Station. The article also undertakes the social problem related to the attempted takeover by the Central Mining Rescue Station S.A. in Bytom full security of twelve departments of the mining rescue SRK S.A. where underground works are still being carried out. As a summary the author faces with the paradoxes of this situation
Equity research - Kering S.A.
No full textMestrado em FinançasEquity research a Kering S.A com o intuito de determinar um determinado price target para o valores das acções da Kering S.A a 31 de Dezembro de 2019.
No processo para determinar o price target foram utilizados 3 modelos de avaliação distintos, Discounted Cash Flow Model, Dividend Discount Model e Multiples Valuation dos quais se obteve um price target de 576.44 EUR representando um upside de 8.9% face ao preço base utilizado para esta analise de 520.10 EUR de 1 de Julho de 2019.This project is mainly comprised on an Equity Research of Kering S.A. to determine a certain price target of Kering's stock by 31st December 2019. This assessment is mostly assembled by a set of assumptions, made the author of these document, for the time period of 2019F-2023F which reflect the historical performance of the company and the current market settings that may impact such target price.
In regards of the computations around the price target definition, three valuation models were covered, the Discounted Cash Flow Model, which discounted all future cash flows generated in the period under analysis and through perpetuity, totaling a price of 580.12 EUR / share, and the Dividend Discount Model and Multiples Valuation Model which totaled 567.00 EUR and 582.22 EUR respectively. Based on these there valuation models, by assigning an equal weight to each one of them, a price target of 576.44 EUR was reached translating into a 8.9% upside potential regarding the reference date of analysis of 525.10 EUR in 1st July 2019.
Once, computed the price target, the final recommendation for these equity research document was defined based on the risk criteria that better described Kering S.A market environment settings, providing this way a solid statement for Kering's share price within the period under analysisinfo:eu-repo/semantics/publishedVersio
Equity research - Kering S.A.
No full textMestrado em FinançasEquity research a Kering S.A com o intuito de determinar um determinado price target para o valores das acções da Kering S.A a 31 de Dezembro de 2019.
No processo para determinar o price target foram utilizados 3 modelos de avaliação distintos, Discounted Cash Flow Model, Dividend Discount Model e Multiples Valuation dos quais se obteve um price target de 576.44 EUR representando um upside de 8.9% face ao preço base utilizado para esta analise de 520.10 EUR de 1 de Julho de 2019.This project is mainly comprised on an Equity Research of Kering S.A. to determine a certain price target of Kering's stock by 31st December 2019. This assessment is mostly assembled by a set of assumptions, made the author of these document, for the time period of 2019F-2023F which reflect the historical performance of the company and the current market settings that may impact such target price.
In regards of the computations around the price target definition, three valuation models were covered, the Discounted Cash Flow Model, which discounted all future cash flows generated in the period under analysis and through perpetuity, totaling a price of 580.12 EUR / share, and the Dividend Discount Model and Multiples Valuation Model which totaled 567.00 EUR and 582.22 EUR respectively. Based on these there valuation models, by assigning an equal weight to each one of them, a price target of 576.44 EUR was reached translating into a 8.9% upside potential regarding the reference date of analysis of 525.10 EUR in 1st July 2019.
Once, computed the price target, the final recommendation for these equity research document was defined based on the risk criteria that better described Kering S.A market environment settings, providing this way a solid statement for Kering's share price within the period under analysisinfo:eu-repo/semantics/publishedVersio
Geographic profiling in Nazi Berlin: fact and fiction
No full textGeographic profiling uses the locations of connected crime sites to make inferences about the probable location of the offender’s ‘anchor point’ (usually a home, but sometimes a workplace). We show how the basic ideas of the method were used in a Gestapo investigation that formed the basis of a classic German novel about domestic resistance to the Nazis during the Second World War. We use modern techniques to re-analyse this case, and show that these successfully locate the Berlin home address of Otto and Elise Hampel, who had distributed hundreds of anti-Nazi postcards, after analysing just 34 of the 214 incidents that took place before their arrest. Our study provides the first empirical evidence to support the suggestion that analysis of minor terrorism-related acts such as graffiti and theft could be used to help locate terrorist bases before more serious incidents occur
Equity research - Kering S.A.
No full textMestrado em FinançasEquity research a Kering S.A com o intuito de determinar um determinado price target para o valores das acções da Kering S.A a 31 de Dezembro de 2019.
No processo para determinar o price target foram utilizados 3 modelos de avaliação distintos, Discounted Cash Flow Model, Dividend Discount Model e Multiples Valuation dos quais se obteve um price target de 576.44 EUR representando um upside de 8.9% face ao preço base utilizado para esta analise de 520.10 EUR de 1 de Julho de 2019.This project is mainly comprised on an Equity Research of Kering S.A. to determine a certain price target of Kering's stock by 31st December 2019. This assessment is mostly assembled by a set of assumptions, made the author of these document, for the time period of 2019F-2023F which reflect the historical performance of the company and the current market settings that may impact such target price.
In regards of the computations around the price target definition, three valuation models were covered, the Discounted Cash Flow Model, which discounted all future cash flows generated in the period under analysis and through perpetuity, totaling a price of 580.12 EUR / share, and the Dividend Discount Model and Multiples Valuation Model which totaled 567.00 EUR and 582.22 EUR respectively. Based on these there valuation models, by assigning an equal weight to each one of them, a price target of 576.44 EUR was reached translating into a 8.9% upside potential regarding the reference date of analysis of 525.10 EUR in 1st July 2019.
Once, computed the price target, the final recommendation for these equity research document was defined based on the risk criteria that better described Kering S.A market environment settings, providing this way a solid statement for Kering's share price within the period under analysisinfo:eu-repo/semantics/publishedVersio
The Case of the Eight Turkish Military Personnel who Sought Asylum in Greece after the Failed 2016 Coup Attempt in Turkey: Fair Trial as a Reason Precluding Non-Refoulement and (Stricto Sensu) Proportionality
No full textThis is the author accepted manuscript. The final version is available from Nomiki Bibliothiki S.A via the link in this recor
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