1,720,969 research outputs found
Acute kidney injury and ischemic stroke
Get PDFPatients with kidney dysfunction have an increased risk of renoparenchymal hypertension and cardiovascular complications (myocardial infarction, stroke, heart failure, cardiovascular death). In general, patients with kidney damage more often die not from end-stage renal failure, but from cardiovascular complications, in particular from stroke. The leading mechanisms for this include activation of the sympathetic and adrenal system, increased atherogenesis, endothelial dysfunction, increased inflammatory factors, changes in the level of lipoproteins, hypertrophy of the left ventricle, and the presence of hypertension
Epidemiology and Management of Stroke in Western Ukraine: Results from a Population-Based Stroke Registery
No full textThe trends of stroke incidence in Chernivtsi: analysis of epidemiological data for a ten-year period and assessment of statistical calculation
No full textEndocrine comorbidity and ischemic stroke: the impact on stroke severity and case fatality
No full textSecondary pathogenetic mechanisms of neural tissue damage in brain concussion
No full textThe state of pro - and antioxidant systems in patients with brain concussion has been studied. The definite patterns of the functioning of these systems in this pathology have been disclose
Stroke-associated pneumonia and acute stroke: frequency, prognostic value and impact of comorbidities
Get PDFThe aim of research was to evaluate the frequency of nosocomial pneumonia and other hospital-acquired complications after acute ischemic stroke, to assess the impact of somatic comorbidity on pneumonia occurrence, and to determine the relation of pneumonia to 28-day stroke case fatality. Methods. We performed a prospective study among 207 patients hospitalized for acute ischemic stroke. Stroke severity was evaluated with National Institutes of Health Stroke Scale. Somatic comorbidity was analyzed and graded with Modified Charlson Comorbidity Index. Post-stroke complications were diagnosed using standardized criteria. Results. Mean score of the admission stroke severity in all patients was 12.3±0.4. Of all strokes, 87.4% developed against a background3 2 of preexisting somatic pathology. Low comorbidity was recorded in 101 patients (48.8%), moderate in 58 (28.0%), high in 48 (23.2%); mean Charlson index score was 1.8±0.07 During admission, one or more medical complications occurred in 61 patients (29.5%). The frequency of pneumonia was 19.3% (40 cases): 27.8% in patients with fatal stroke vs. 8.7% in stroke survivors (ð<0.01). The highest was the frequency of pneumonia in patients with high comorbidity (37.5%) compared to those with low (11.9%) or moderate index scores (17.2%). The further analysis showed positive correlation between the increase of Charlson comorbidity index and pneumonia occurrence (r =0,389). Nosocomial pneumonia was related to 28 days case fatality in ischemic stroke (ф=0,241) and this complication significantly increased the probability of death in acute period -OR=3.94 (95% CI 1.59-9.76). Conclusions. Nosocomial pneumonia is a life-threatening complication that affects almost every 5th patient with acute ischemic stroke. The occurrence of stroke-associated pneumonia positively correlates with the higher level of preexisting somatic comorbidity. Development of pneumonia after acute ischemic stroke is an adverse prognostic factor, which increases the probability of 28-days case fatality by 3.9-fold
Correlations of the index of evaluating somatic pathology with the severity of the course during the acutest реriod of cerebral stroke
No full textПроведено клінічно-неврологічне обстеження 333 пацієнтів у найгострішому періоді мозкового інсульту з оцінкою загальномозкових, вогнищевих симптомів, а також тяжкості фонової соматичної патології з використанням індексу коморбідності Чарлсона. Встановлено зворотний кореляційний зв'язок індексу Чарлсона з рівнем свідомості за шкалою коми Глазго і позитивну кореляцію з тяжкістю інсульту за шкалою NIHSS. Результати дослідження свідчать про значущість індексу та можливості його використання з метою прогнозування наслідків інсульту і подальшої корекції тактики лікування, реабілітації і вторинної профілактики.
Проведено клинико-неврологическое обследование 333 больных в острейшем периоде мозгового инсульта с оценкой общемозговых, очаговых симптомов, а также тяжести фоновой соматической патологии с использованием индекса коморбидности Чарлсона. Установлена обратная корреляционная связь индекса Чарлсона со степенью нарушения сознания по шкале комы Глазго и положительная корреляция с тяжестью инсульта по шкале NIHSS. Результаты исследования свидетельствуют о значимости индекса и возможности его использования с целью прогнозирования последствий инсульта и дальнейшей коррекции тактики лечения, реабилитации и вторичной профилактики.
The author has carried out a cliniconeurological examination of 333 patients during the acutest period of cerebral stroke with an evaluation of general cerebral, focal signs, as well as the severity of background somatic pathology, using the Charlson comorbidity index. A correlative feedback of the Charlson index with the level of consciousness according to the Glasgow Coma Scale and the positive correlation with the severity of stroke based on the NIHS scale have been estabilished. The results of the investigation are indicative of the significance of the index and possibilities of its use for the purpose of prognosticating the consequences of stroke and further correction of the therapeutic approach, rehabilitation and secondary prophylaxis
Stroke burden in Ukraine: analysis of the official stroke statistics and overview of population-based epidemiological studies
Get PDFAnalysis of the official statistical reports has shown an increase in stroke incidence rate in Ukrainian population, considerable diversities in stroke occurrence and dissimilar trends of incidence in different geographical areas for the last 19 years. High-quality, population-based stroke epidemiology studies are necessary to provide a reliable data on key indicators of stroke burden. The establishment of effective stroke observation system in Ukraine will allow prevention strategies planning, decreasing stroke incidence and improving stroke management
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