1,721,008 research outputs found
Humidity sensation, cockroaches, worms and humans: are common sensory mechanisms for hygrosensation shared across species?
No full textAlthough the ability to detect humidity (i.e. hygrosensation) represents an important sensory attribute in many animal species (including humans), the neurophysiological and molecular bases of such sensory ability remain largely unknown in many animals. Recently, Russell and colleagues (Russell J, Vidal-Gadea AG, Makay A, Lanam C, Pierce-Shimomura JT. Proc Natl Acad Sci U S A 111: 8269-8274, 2014) provided for the first time neuromolecular evidence for the sensory integration of thermal and mechanical sensory cues which underpin the hygrosensation strategy of an animal (i.e. the free-living roundworm Caenorhabditis elegans) which lacks specific sensory organs for humidity detection (i.e. hygroreceptors). Due to the remarkable similarities in the hygrosensation transduction mechanisms used by hygroreceptor-provided (e.g. insects) and hygroreceptor-lacking species (e.g. roundworms and humans), Russell and colleagues' findings highlight potentially universal mechanisms for humidity detection which could be shared across a wide range of species, including humans
Neurophysiology of Skin Thermal Sensations
Full text linkUndoubtedly, adjusting our thermoregulatory behavior represents the most effective mechanism to maintain thermal homeostasis and ensure survival in the diverse thermal environments that we face on this planet. Remarkably, our thermal behavior is entirely dependent on the ability to detect variations in our internal (i.e., body) and external environment, via sensing changes
in skin temperature and wetness. In the past 30 years, we have seen a significant expansion of our understanding of the molecular, neuroanatomical, and neurophysiological mechanisms that allow humans to sense temperature and humidity. The discovery of temperature-activated ion
channels which gate the generation of action potentials in thermosensitive neurons, along with the characterization of the spino-thalamo-cortical thermosensory pathway, and the development of neural models for the perception of skin wetness, are only some of the recent advances which have provided incredible insights on how biophysical changes in skin temperature and wetness
are transduced into those neural signals which constitute the physiological substrate of skin thermal and wetness sensations. Understanding how afferent thermal inputs are integrated and how these contribute to behavioral and autonomic thermoregulatory responses under normal brain function is
critical to determine how these mechanisms are disrupted in those neurological conditions, which see the concurrent presence of afferent thermosensory abnormalities and efferent thermoregulatory
dysfunctions. Furthermore, advancing the knowledge on skin thermal and wetness sensations is crucial to support the development of neuroprosthetics. In light of the aforementioned text, this review will focus on the peripheral and central neurophysiological mechanisms underpinning skin thermal and wetness sensations in humans
Characteristics of the local cutaneous sensory thermo-neutral zone
No full textSkin temperature detection thresholds have been used to measure human cold and warm sensitivity across the temperature continuum. They exhibit a sensory zone within which neither warm nor cold sensations prevail. This zone has been widely assumed to coincide with steady-state local skin temperatures between 32 and 34°C, but its underlying neurophysiology has been rarely investigated. In this study we employ two approaches to characterize the properties of sensory thermoneutrality, testing for each whether neutrality shifts along the temperature continuum depending on adaptation to a preceding thermal state. The focus is on local spots of skin on the palm. Ten participants (age: 30.3 ± 4.8 yr) underwent two experiments. Experiment 1 established the cold-to-warm inter-detection threshold range for the palm’s glabrous skin and its shift as a function of 3 starting skin temperatures (26, 31, or 36°C). For the same conditions, experiment 2 determined a thermally neutral zone centered around a thermally neutral point in which thermoreceptors’ activity is balanced. The zone was found to be narrow (~0.98 to ~1.33°C), moving with the starting skin temperature over the temperature span 27.5–34.9°C (Pearson r = 0.94; P < 0.001). It falls within the cold-to-warm inter-threshold range (~2.25 to ~2.47°C) but is only half as wide. These findings provide the first quantitative analysis of the local sensory thermoneutral zone in humans, indicating that it does not occur only within a specific range of steady-state skin temperatures (i.e., it shifts across the temperature continuum) and that it differs from the inter-detection threshold range both quantitatively and qualitatively. These findings provide insight into thermoreception neurophysiology
Thermosensory mapping of skin wetness sensitivity across the body of young males and females at rest and following maximal incremental running
Full text linkKey points: Humans lack skin receptors for wetness (i.e. hygroreceptors), yet we present a remarkable wetness sensitivity. Afferent inputs from skin cold-sensitive thermoreceptors are key for sensing wetness; yet, it is unknown whether males and females differ in their wetness sensitivity across their body and whether high intensity exercise modulates this sensitivity. We mapped sensitivity to cold, neutral and warm wetness across five body regions and show that females are more sensitive to skin wetness than males, and that this difference is greater for cold than warm wetness sensitivity. We also show that a single bout of maximal exercise reduced the sensitivity to skin wetness (i.e. hygro-hypoesthesia) of both sexes as a result of concurrent decreases in thermal sensitivity. These novel findings clarify the physiological mechanisms underpinning this fundamental human sensory experience. In addition, they indicate sex differences in thermoregulatory responses and will inform the design of more effective sport and protective clothing, as well as thermoregulatory models. Abstract: Humans lack skin hygroreceptors and we rely on integrating cold and tactile inputs from A-type skin nerve fibres to sense wetness. Yet, it is unknown whether sex and exercise independently modulate skin wetness sensitivity across the body. We mapped local sensitivity to cold, neutral and warm wetness of the forehead, neck, underarm, lower back and dorsal foot in 10 males (27.8 ± 2.7 years; 1.92 ± 0.1 m2 body surface area) and 10 females (25.4 ± 3.9 years; 1.68 ± 0.1 m2 body surface area), at rest and post maximal incremental running. Participants underwent our quantitative sensory test where they reported the magnitude of thermal and wetness perceptions (visual analogue scale) resulting from the application of a cold (5°C below skin temperature) wet (0.8 mL of water), neutral wet and warm wet (5°C above skin temperature) thermal probe (1.32 cm2) to five skin sites. We found that: (i) females were ∼14% to ∼17% more sensitive to cold-wetness than males, yet both sexes were as sensitive to neutral- and warm-wetness; (ii) regional differences were present for cold-wetness only, and these followed a craniocaudal increase that was more pronounced in males (i.e. the foot was ∼31% more sensitive than the forehead); and (iii) maximal exercise reduced cold-wetness sensitivity over specific regions in males (i.e. ∼40% decrease in foot sensitivity), and also induced a generalized reduction in warm-wetness sensitivity in both sexes (i.e. ∼4% to ∼6%). For the first time, we show that females are more sensitive to cold wetness than males and that maximal exercise induce hygro-hypoesthesia. These novel findings expand our knowledge on sex differences in thermoregulatory physiology
Independent and interactive effects of thermal stress and mental fatigue on manual dexterity
Full text linkMany occupations and sports require high levels of manual dexterity under thermal stress and mental fatigue. Yet, multistressor studies remain scarce. We quantified the interactive effects of thermal stress and mental fatigue on manual dexterity. Seven males (21.1 ± 1.3 yr) underwent six separate 60-min trials characterized by a combination of three air temperatures (hot, 37C; neutral, 21C; cold, 7C) and two mental fatigue states (MF, mental fatigue induced by a 35-min cognitive battery; no-MF, no mental fatigue). Participants performed complex (O'Connor test) and simple (hand-tool test) manual tasks pre- and posttrial to determine stressor-induced performance changes. We monitored participants' rectal temperature and hand skin temperature (Thand) continuously and assessed the reaction time (handclick test) and subjective mental fatigue (5-point scale). Thermal stress (P < 0.0001), but not mental fatigue (P = 0.290), modulated Thand (heat, +3.3C [95% CI: +0.2, +6.5]; cold, 7.5C [10.7, 4.4]). Mental fatigue (P = 0.021), but not thermal stress (P = 0.646), slowed the reaction time (10%) and increased subjective fatigue. Thermal stress and mental fatigue had an interactive effect on the complex manual task (P = 0.040), with cold-no-MF decreasing the performance by 22% [39, 5], whereas neutral-MF, cold-MF, and heat-MF by 36% [53, 19], 34% [52, 17], and 36% [53, 19], respectively. Only mental fatigue decreased the performance in the simple manual task (30% [43, 16] across all thermal conditions; P = 0.002). Cold stress-induced impairments in complex manipulation increase with mental fatigue; yet combined stressors' effects are no greater than those of mental fatigue alone, which also impairs simple manipulation. Mental fatigue poses a greater challenge to manual dexterity than thermal stress
The effects of vibration during maximal graded cycling exercise: A pilot study
Full text linkWhole Body Vibration training is studied and used in different areas, related to sport performance and rehabilitation. However, few studies have investigated the effects of Vibration (Vib) exposure on aerobic performance through the application of this concept to cycling exercise. A specifically designed vibrating cycloergometer, the powerBIKETM, was used to compare the effects of Vib cycling exercise and normal cycling on different physiological parameters during maximal graded exercise test. Twelve recreationally active male adults (25 ± 4.8 yrs; 181.33 ± 5.47 cm; 80.66 ± 11.91 kg) performed two maximal incremental cycling tests with and without Vib in a blockrandomized order. The protocol consisted of a 4 min warm up at 70 rev·min -1 followed by incremental steps of 3 min each. Cycling cadence was increased at each step by 10 rev·min -1 until participants reached their volitional exhaustion. Respiratory gases (VO 2, VCO 2), Heart Rate, Blood Lactate and RPE were collected during the test. Paired t-tests and Correlation Coefficients were used for statistical analysis. A significantly greater (P<0.05) response in the VO 2, HR, BLa and RPE was observed during the Vib trial compare to normal cycling. No significant differences were found in the maximal aerobic power (Vib 34.32 ± 9.70 ml·kg -1·min -1; no Vib 40.11 ± 9.49 ml·kg -1·min -1). Adding Vib to cycling exercise seems eliciting a quicker energetic demand during maximal exercise. However, mechanical limitations of the vibrating prototype could have affected the final outcomes. Future studies with more comparative setting are recommended to deeply appraise this concept. © Journal of Sports Science and Medicine (2012)
IS HYPOXIA A TRAINING STIMULUS FOR ENDURANCE ATHLETES’ PERFORMANCE? A BRIEF REVIEW.
No full textABSTRACT: Background. There is increasing popularity among elite
athletes to endorse altitude training to enhance performance levels. Altitude
training may be used for enhanced performance at sea level, or to acclimatise
to a competition at altitude. Enhancement of muscle oxidative capacity,
muscle glycolytic capacity, skeletal muscle oxygenation, oxygen transport
and storage within the muscle, and hormonal regulation have been reported
with altitude training. Aim. The aim of this review is to analyse current
knowledge on hypoxic training and its possible relation to enhanced
endurance performance. This paper will consider factors including the
process of enhanced sea level performance in relation to natural hypoxic
exposures to altitude conditions. Methods. A literature search was
performed from the years 1968 to 2011 on the electronic databases
PUBMED. Key search words included endurance, altitude and performance.
Results/Conclusion. This brief review has highlighted the lack of
homogeneity in the scientific approach to the evaluation of hypoxic exposure
effectiveness in endurance performance. However, relevant performance
benefits have been shown in several studies and represent a realistic support
in order not to exclude the possibility to implement altitude training in the
annual training plan of endurance athletes
Tactile cues significantly modulate the perception of sweat-induced skin wetness independently of the level of physical skin wetness.
Full text linkHumans sense the wetness of a wet surface through the somatosensory integration of thermal and tactile inputs generated by the interaction between skin and moisture. However, little is known on how wetness is sensed when moisture is produced via sweating. We tested the hypothesis that, in the absence of skin cooling, intermittent tactile cues, as coded by low-threshold skin mechanoreceptors, modulate the perception of sweat-induced skin wetness, independently of the level of physical wetness. Ten males (22 yr old) performed an incremental exercise protocol during two trials designed to induce the same physical skin wetness but to induce lower (TIGHT-FIT) and higher (LOOSE-FIT) wetness perception. In the TIGHT-FIT, a tight-fitting clothing ensemble limited intermittent skin-sweat-clothing tactile interactions. In the LOOSE-FIT, a loose-fitting ensemble allowed free skin-sweat-clothing interactions. Heart rate, core and skin temperature, galvanic skin conductance (GSC), and physical (wbody) and perceived skin wetness were recorded. Exercise-induced sweat production and physical wetness increased significantly [GSC: 3.1 μS, SD 0.3 to 18.8 μS, SD 1.3, P < 0.01; wbody: 0.26 no-dimension units (nd), SD 0.02, to 0.92 nd, SD 0.01, P < 0.01], with no differences between TIGHT-FIT and LOOSE-FIT (P > 0.05). However, the limited intermittent tactile inputs generated by the TIGHT-FIT ensemble reduced significantly whole-body and regional wetness perception (P < 0.01). This reduction was more pronounced when between 40 and 80% of the body was covered in sweat. We conclude that the central integration of intermittent mechanical interactions between skin, sweat, and clothing, as coded by low-threshold skin mechanoreceptors, significantly contributes to the ability to sense sweat-induced skin wetness
One repetition maximum bench press performance: A new approach for its evaluation in inexperienced males and females: A pilot study
Full text linkSummary The aim of this study was to evaluate a new method to perform the one repetition
maximum (1RM) bench press test, by combining previously validated predictive and practical
procedures. Eight young male and 7 females participants, with no previous experience of resistance
training, performed a first set of repetitions to fatigue (RTF) with a workload corresponding
to 1/3 of their body mass (BM) for a maximum of 25 repetitions. Following a 5-min
recovery period, a second set of RTF was performed with a workload corresponding to 1/2 of
participants’ BM. The number of repetitions performed in this set was then used to predict
the workload to be used for the 1RM bench press test using Mayhew’s equation. Oxygen consumption,
heart rate and blood lactate were monitored before, during and after each 1RM
attempt. A significant effect of gender was found on the maximum number of repetitions
achieved during the RTF set performed with 1/2 of participants’ BM (males: 25.0 6.3; females:
11.0x 10.6; t Z 6.2; p < 0.001). The 1RM attempt performed with the workload predicted
by Mayhew’s equation resulted in females performing 1.2 0.7 repetitions, while males
performed 4.8 1.9 repetitions. All participants reached their 1RM performance within 3 attempts,
thus resulting in a maximum of 5 sets required to successfully perform the 1RM bench
press test. We conclude that, by combining previously validated predictive equations with
practical procedures (i.e. using a fraction of participants’ BM to determine the workload for an RTF set), the new method we tested appeared safe, accurate (particularly in females) and
time-effective in the practical evaluation of 1RM performance in inexperienced individuals
Biophysical, thermo-physiological and perceptual determinants of cool-seeking behaviour during exercise in younger and older women
Full text linkWomen continue to be under-represented in thermoregulatory research despite their undergoing unique physiological changes across the lifespan. This study investigated the biophysical, thermo-physiological, and perceptual determinants of cool-seeking behaviour during exercise in younger and older women. Eleven younger (25 ± 5 years; 1.7 ± 0.1 m; 63.1 ± 5.2 kg) and 11 older women (53 ± 6 years; 1.7 ± 0.1 m; 65.4 ± 13.9 kg) performed a 40-min incremental cycling test in a thermoneutral environment (22 ± 1.7°C; 36 ± 4% relative humidity). Throughout the test, participants freely adjusted the temperature of a cooling probe applied to their wrists to offset their thermal discomfort. We continuously recorded the probe–wrist interface temperature to quantify participants’ cool-seeking behaviour. We also measured changes in participants’ rate of metabolic heat production, core and mean skin temperatures, and skin wetness. Finally, we body-mapped participants’ skin heat, cold and wetness sensitivity. Our results indicated that: (1) older and younger women exhibited similar onset and magnitude of cool-seeking behaviour, despite older women presented reduced autonomic heat-dissipation responses (i.e., whole-body sweat losses); (2) older women's thermal behaviour was less determined by changes in core temperature (this being a key driver in younger women), and more by changes in multiple thermo-physiological and biophysical parameters (i.e., physical skin wetness, temperature and heat production); (3) older women did not present lower regional skin thermal and wetness sensitivity than younger women. We conclude that predictions of female cool-seeking behaviours based on thermo-physiological variables should consider the effects of ageing. These findings are relevant for the design of wearable cooling systems and sports garments that meet the thermal needs of women across the lifespan
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