122,185 research outputs found
La gestione personalizzata del paziente con malattia neurodegenerativa: dai sensori indossabili, alla valutazione online e al training cognitivo a domicilio
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Virtual Naming and Geographic Routing on Wireless Sensor Networks
No full textWe consider the problem of routing with guaranteed delivery in wireless sensor networks where physical locations of the sensors are not known. We propose a naming protocol which defines a 2-dimensional coordinate system and a routing protocol (Ibrid) which ensures guaranteed delivery of packets. We show by means of simulation that in realistic settings where the network includes voids and obstacles, Ibridfinds routess hortest than those obtained with existing geographic routing algorithms over physical coordinates
Il docente tutor nella scuola autonoma
No full textQuesto volume è finalizzato fondamentalmente ad analizzare e discutere le funzioni che è chiamato a svolgere il docente tutor nel contesto di un’istituzione scolastica autonoma, a seguito dell’introduzione di questa nuova figura nell’economia complessiva della nuova organizzazione del sistema-scuola stabilita dalla riforma Moratti (attraverso la legge 53/2003 e i conseguenti decreti attuativi), innovazione che ha immediatamente suscitato un vivacissimo dibattito, talora con pungenti acumi polemici, fra i pedagogisti e nel mondo della scuola e della formazione. Le parti redatte da Emilio Lastrucci, in particolare, sono volte a illustrare e discutere il ruolo che dovrebbe assolvere il docente cui vengono assegnate funzioni tutoriali, nonché ad esporre le linee salienti della proposta di modello applicativo che viene sviluppata nelle parti centrali del libro. Lastrucci, inoltre, presenta un preliminare excursus storico-critico, volto ad inquadrare la funzione dell’attività di tutoring nell’ambito dell’orientamento scolastico, da cui le funzioni tutoriali previste dalla riforma hanno tratto sostanzialmente origine. La necessità di predisporre e porre in essere efficaci interventi di tutoring di natura psico-motivazionale e con finalità eminentemente orientative rappresenta infatti una diretta conseguenza dell’esigenza di intrecciare in modo continuo l’attività formativa ad una attività di supporto psicologico tesa a guidare ed accompagnare l’alunno nella definizione ed eventuale ri-definizione dei suoi percorsi formativi e professionali, così come nel suo processo di maturazione e sviluppo della personalità più complessivamente considerato. L’approfondimento di questo aspetto trova ragione nella convinzione degli autori che se non vi è dubbio che la funzione tutoriale rivolta all’alunno - e che in senso più proprio appare definire anche sul piano terminologico la ragione saliente e fondante del ruolo del docente-tutor – affonda le sue radici nel tutoring orientativo, appare altresì abbastanza evidente come questa rappresenti in qualche modo anche il perno attorno al quale ruotano le altre funzioni, che hanno quali interlocutori il team docente e la famiglia. Lastrucci entra infine nel merito di tutte le principali questioni sulle quali si è imperniato il dibattito attorno alla figura del docente tutor, in particolare sull’attribuzione a quest’ultimo di funzioni di counselling e sul così tanto discusso ruolo di “insegnante prevalente”. In tale discussione l’autore sviluppa argomentazioni che affondano le radici in una approfondita riflessione di natura psico-pedagogica e che trovano altresì riscontro nelle esperienze più significative ed avanzate e nella ricerca e sperimentazione sul campo
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Nuovi approcci molecolari nello studio della fisiopatologia del diabete gestazionale
No full textAbstract research study 1
Cross-talk between foetal membranes and visceral adipose tissue involves HMGB1-RAGE and VIP-VPAC2 pathways in human gestational diabetes mellitus
Introduction: Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is first diagnosed during pregnancy. Foetal membranes (FMs) and maternal visceral adipose tissue (VAT) secrete various molecules that are relevant players in the pathogenesis of GDM.
Aim: This pilot study aimed to comparatively evaluate the expression of high mobility group box 1 protein (HMGB1) and its receptor for advanced glycation end products (RAGE), and vasoactive intestinal peptide (VIP) and its receptors (VPAC1, VPAC2) in FMs and VAT in GDM and in healthy pregnant women.
Patients and Methods: FMs, omental VAT explants, and serum samples were obtained from twelve patients with GDM and twelve pregnant women with normal glucose tolerance (NGT) at delivery. The expression of HMGB1, RAGE and VIP, VPAC1 and VPAC2 was detected by Western Blotting in explants; circulating levels and in vitro release of HMGB1 and VIP were measured by ELISA tests.
Results: HMGB1 tissue expression was higher in FMs obtained from GDM patients (p=0.02) than in FMs from NGT women. VPAC2 (p=0.03) and RAGE (p=0.03) tissue expressions were significantly increased in VAT from GDM patients compared to NGT. Only FMs of NGT released detectable levels of HMGB1, which was not observed in samples obtained from GDM. VAT of GDM released lower levels of VIP (p=0.05) than NGT samples.
Conclusions: This study suggests that a fine tuned regulation exists between FMs and VAT throughout pregnancy to maintain immune metabolic homeostasis. In GDM a balance between pro-inflammatory and anti-inflammatory mediators has been observed. Further studies are needed to establish their exact role on foetal and maternal outcomes in GDM.
Abstract research study 2
MicroRNA expression profile in circulating exosomes and plasma of patients with GDM and healthy pregnant women
Introduction: MicroRNAs are small non-coding RNAs, playing critical roles in modulating gene expression. The deregulation of microRNAs has been observed in GDM, highlighting their crucial involvement both in the pathogenic mechanisms of this condition and in the development of its complications. Circulating microRNAs can be packaged into exosomes, and exosome signalling has emerged as a novel mechanism of cell-to-cell communication. Through exosomes, microRNAs are delivered in distant target cells and are able to affect gene expression.
Aim: The aim of this study was to explore microRNA expression in circulating exosomes and in plasma obtained from patients with GDM and healthy control subjects in the third trimester of gestation, to potentially elucidate some relevant aspects of GDM pathophysiology and individuate novel potential candidate biomarkers for GDM.
Patients and Methods: A profiling cohort of plasma samples collected from GDM (n=3, age: 34.7 ± 4.9 years; BMI 27.0 ± 3.7 Kg/m2) and NGT women (n=3, age: 34.3 ± 3.1 years; BMI 26.4 ± 1.1 Kg/m2) was recruited. In addition, a profiling cohort of healthy non-pregnant age- and BMI-matched women (NP, n=5) was used as negative control. The microRNA patterns of expression in exosomes and plasma have been assessed with the innovative technology NanoString nCounter microRNA expression (NanoString Technologies inc., Seattle, WA, USA). Target gene identification and bioinformatics analysis of the differentially expressed microRNAs have been performed with Ingenuity Pathway Analysis (IPA, QIAGEN Redwood City, USA).
Results: A specific set of microRNAs resulted to be differentially expressed in exosomes and plasma from GDM patients compared to NGT. Specifically, five exosomal microRNAs were significantly upregulated, while 23 were downregulated in GDM compared to NGT. As for plasma, 4 microRNA were upregulated, while 9 were downregulated in GDM compared to NGT. In addition, two microRNAs, miR-196a-5p and miR-652, resulted to be significantly downregulated in GDM compared both to NGT and NP in exosomes and plasma, respectively, suggesting that their deregulation might hallmark GDM pregnancy. In bioinformatics analysis the major predicted target genes and biological processes of the deregulated microRNAs were associated with insulin resistance, abnormal glucose and lipid metabolism, consistently linked to GDM pathophysiology.
Conclusions: GDM might markedly alter microRNA profile in exosomes and plasma, conceivably mirroring the metabolic alterations described in GDM pregnancy. In light of this, exploring circulating microRNA expression might help unravel the molecular events leading to the metabolic alterations observed in GDM
Ruolo dell’attigrafia nello screening e nel follow-up longitudinale della Narcolessia di Tipo 1
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