170,188 research outputs found
TIMED FLAT INFUSION OF 5-FLUOROURACIL INCREASES THE TOLERABILITY OF 5-FLUOROURACIL/DOCETAXEL REGIMEN IN METASTATIC BREAST CANCER: A DOSE-FINDING STUDY.
No full textJournal home > Archive > Clinical > Abstract Clinical British Journal of Cancer (2004) 91, 618–620. doi:10.1038/sj.bjc.6601971 www.bjcancer.com Published online 3 August 2004 Timed flat infusion of 5-fluorouracil increases the tolerability of 5-fluorouracil/docetaxel regimen in metastatic breast cancer: a dose-finding study C Ficorella1, M F Morelli1, E Ricevuto1, K Cannita1, G Porzio1, P Lanfiuti Baldi1, G Cianci1, ZC Di Rocco1, C Natoli2, N Tinari2, F De Galitiis1, F Calista1 and P Marchetti1 1Medical Oncology, University of L'Aquila, Italy 2Department of Oncology and Neuroscience Section of Medical Oncology, University of Chieti, Italy Correspondence: Dr C Ficorella, Department of Experimental Medicine, University of L'Aquila, Via Vetoio, Coppito, L'Aquila 67100, Italy. E-mail: [email protected] Received 4 February 2004; Revised 7 May 2004; Accepted 10 May 2004; Published online 3 August 2004. Top of pageAbstract A dose-finding study was undertaken to determine the maximum-tolerated dose, and the recommended dose of docetaxel in combination with 12-h timed (22:00–10:00) flat infusion of 5-fluorouracil (5-FU) in metastatic breast cancer patients. This schedule seems to reduce the occurrence of stomatitis of the docetaxel and infusional 5-FU regimen. Keywords: breast cancer, docetaxel, 5-fluorouracil Top of page MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REVIEWS Mechanisms of Disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases Nature Clinical Practice Gastroenterology & Hepatology Review (01 Sep 2005
Multimodality treatment in metastatic gastric cancer: From past to next future
No full textGastric cancer (GC) still remains an incurable disease in almost two-thirds of the cases. However, a deeper knowledge of its biology in the last few years has revealed potential biomarkers suitable for tailored treatment with targeted agents. This aspect, together with the improvement in early supportive care and a wiser use of the available cytotoxic drugs across multiple lines of treatment, has resulted in incremental and progressive survival benefits. Furthermore, slowly but surely, targeted therapies and immune checkpoint inhibitors are revising the therapeutic scenario even in metastatic GC and especially in particular subgroups. Moreover, important study results regarding the possible role of an integrated approach combining systemic, surgical, and locoregional treatment in carefully selected oligometastatic GC patients are awaited. This review summarizes the state-of-the-art and the major ongoing trials involving a multimodal treatment of metastatic GC
Effect of cell size on ambient light rejection in SiPM-based Time-of-Flight range sensors
No full textSilicon PhotonMultipliers (SiPM) have recently been proposed for Time-of-Flight ranging applications thanks to their high gain and excellent performances in terms of timing resolution. This work reports on the preliminary evaluation of a SiPM-based receiver for a Time-of-Flight (ToF) range meter at different ambient light intensities. A low-power 10-MHz picosecond pulsed laser was used as a light source and a Time-Correlated Single Photon Counting (TCSPC) module was employed to measure the time delay distribution between the emitted and reflected laser signal. Three different SiPMs with the same active area of 1×1 mm^2 but different cell-size (40×40μm^2, 20×20μm^2 and 15×15μm^2) have been considered for the receiver. The system dynamic range, distance measurement precision and accuracy have been analysed at different ambient light intensities. Devices with smaller cell size exhibit greater ambient light rejection, with a better single-shot precision, a time walk lower than 25ps and a factor 3 improvement in the maximum tolerated ambient light intensity
Knowledge, attitudes and associated behaviors of young Italian medical oncologists in management of cancer pain: Preliminary data of a National survey
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Endocrine resistance in breast cancer: biological mechanisms and clinical implications to develop new treatment strategies
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