86,956 research outputs found
TIMED FLAT INFUSION OF 5-FLUOROURACIL INCREASES THE TOLERABILITY OF 5-FLUOROURACIL/DOCETAXEL REGIMEN IN METASTATIC BREAST CANCER: A DOSE-FINDING STUDY.
No full textJournal home > Archive > Clinical > Abstract Clinical British Journal of Cancer (2004) 91, 618–620. doi:10.1038/sj.bjc.6601971 www.bjcancer.com Published online 3 August 2004 Timed flat infusion of 5-fluorouracil increases the tolerability of 5-fluorouracil/docetaxel regimen in metastatic breast cancer: a dose-finding study C Ficorella1, M F Morelli1, E Ricevuto1, K Cannita1, G Porzio1, P Lanfiuti Baldi1, G Cianci1, ZC Di Rocco1, C Natoli2, N Tinari2, F De Galitiis1, F Calista1 and P Marchetti1 1Medical Oncology, University of L'Aquila, Italy 2Department of Oncology and Neuroscience Section of Medical Oncology, University of Chieti, Italy Correspondence: Dr C Ficorella, Department of Experimental Medicine, University of L'Aquila, Via Vetoio, Coppito, L'Aquila 67100, Italy. E-mail: [email protected] Received 4 February 2004; Revised 7 May 2004; Accepted 10 May 2004; Published online 3 August 2004. Top of pageAbstract A dose-finding study was undertaken to determine the maximum-tolerated dose, and the recommended dose of docetaxel in combination with 12-h timed (22:00–10:00) flat infusion of 5-fluorouracil (5-FU) in metastatic breast cancer patients. This schedule seems to reduce the occurrence of stomatitis of the docetaxel and infusional 5-FU regimen. Keywords: breast cancer, docetaxel, 5-fluorouracil Top of page MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REVIEWS Mechanisms of Disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases Nature Clinical Practice Gastroenterology & Hepatology Review (01 Sep 2005
Effect of cell size on ambient light rejection in SiPM-based Time-of-Flight range sensors
No full textSilicon PhotonMultipliers (SiPM) have recently been proposed for Time-of-Flight ranging applications thanks to their high gain and excellent performances in terms of timing resolution. This work reports on the preliminary evaluation of a SiPM-based receiver for a Time-of-Flight (ToF) range meter at different ambient light intensities. A low-power 10-MHz picosecond pulsed laser was used as a light source and a Time-Correlated Single Photon Counting (TCSPC) module was employed to measure the time delay distribution between the emitted and reflected laser signal. Three different SiPMs with the same active area of 1×1 mm^2 but different cell-size (40×40μm^2, 20×20μm^2 and 15×15μm^2) have been considered for the receiver. The system dynamic range, distance measurement precision and accuracy have been analysed at different ambient light intensities. Devices with smaller cell size exhibit greater ambient light rejection, with a better single-shot precision, a time walk lower than 25ps and a factor 3 improvement in the maximum tolerated ambient light intensity
NanoGraphene Oxide: a new material for a non-invasive and non-destructive strategy to remove biofilms from rock surfaces
No full textWhat is known about theragnostic strategies in colorectal cancer
No full textDespite the paradigmatic shift occurred in recent years for defined molecular subtypes in the metastatic setting treatment, colorectal cancer (CRC) still remains an incurable disease in most of the cases. Therefore, there is an urgent need for new tools and biomarkers for both early tumor diagnosis and to improve personalized treatment. Thus, liquid biopsy has emerged as a minimally invasive tool that is capable of detecting genomic alterations from primary or metastatic tumors, allowing the prognostic stratification of patients, the detection of the minimal residual disease after surgical or systemic treatments, the monitoring of therapeutic response, and the development of resistance, establishing an opportunity for early intervention before imaging detection or worsening of clinical symptoms. On the other hand, preclinical and clinical evidence demonstrated the role of gut microbiota dysbiosis in promoting inflammatory responses and cancer initiation. Altered gut microbiota is associated with resistance to chemo drugs and immune checkpoint inhibitors, whereas the use of microbe-targeted therapies including antibiotics, pre-probiotics, and fecal microbiota transplantation can restore response to anticancer drugs, promote immune response, and therefore support current treatment strategies in CRC. In this review, we aim to summarize preclinical and clinical evidence for the utilization of liquid biopsy and gut microbiota in CRC
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A Linear CMOS Sensor for 3D Vision with Merged I-TOF and OT Techniques
No full text3DJAM is a novel 3D image sensor, implemented with a 3.3V, 0.35μm CMOS technology, that combines the Optical Triangulation (OT) and the Indirect Time of Flight (ITOF) techniques in a single chip for range finding scanners. It has been designed to cover very large depth scenes (up to 20 meters), achieving sub-millimeter resolution over the OT range (below 2 meters), working with a single pulsed laser source and also taking advantage of ambient light removal. The chip embeds also a programmable logic unit, which supervises over all the internal functions (like timing, pipelining, data transfer), a power supply unit (for both the analogue and the digital subsystems) and an analogue output buffer that can drive an external ADC for data acquisitio
HICCUP IN PATIENTS WITH ADVANCED CANCER SUCCESSFULLY TREATED WITH GABAPENTIN: REPORT OF THREE CASES
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