2,277 research outputs found
Immunological responses in cervical neoplasia Immunological status of patients with cervical carcinoma and HPV-specific cytotoxic lymphocyte responses in women with cervical neoplasia
No full textSIGLEAvailable from British Library Document Supply Centre-DSC:DXN016734 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Repositioning the graphic designer as researcher
No full textIn academic terms, the discipline of graphic design is relatively young. Consequently the position of the discipline within academic territory, and the role of the designer, continue to be debated. In part, these debates have been a product of attempts to define and defend the discipline’s borders from within, in order to establish a sense of the role of graphic design and the graphic designer as commensurate with other disciplines both within and beyond art and design. In recent years graphic designers have variously been defined as ‘authors’, ‘producers’ and ‘readers’, yet none of these definitions seem to have provided any kind of productive or lasting impact within the academy. This paper suggests that rather than continue to seek territorial definitions and positions from within, it could be more productive to look beyond the confines of the discipline. Gaining a broader, interdisciplinary perspective on, and understanding of, qualitative research methods from other disciplines may enable the graphic designer to more fully position his or her practice within the wider academy. Such a perspective could help facilitate the repositioning and redefinition of the graphic designer as ‘researcher’ - a move that would be productive in relation to the future development of postgraduate research within the discipline
Quantitative measurement of Human Papillomavirus type 16 L1/L2 DNA methylation correlates with cervical disease grade
No full textBackgroundPersistent infection with Human Papillomavirus (HPV) type 16 causes the majority of cervical cancers. Genital HPV infection is very common, but neoplastic progression is uncommon. There is an urgent need to identify biomarkers associated with cervical neoplasia that can be used to triage women who test positive for HPV.ObjectivesTo assess the ability of quantitative measurement of HPV16 DNA methylation to separate samples of different cytology grades and cervical cancers, and determine which of the assessed regions of the HPV genome and individual CpGs are most informative.Study designDNA methylation was quantified by pyrosequencing of bisulphite converted DNA from liquid based cytology samples from 17 women with normal cytology and 20 women with severe dyskaryosis, and from fixed tissue from 24 women with cervical cancer. Methylation was assessed in the HPV Long Control Region (LCR), E2 and L1/L2 regions.ResultsIn cervical cancers, increased HPV DNA methylation was present in all regions. Increased methylation was also observed in severely dyskaryotic relative to normal samples, but only in the E2 and L1/L2 regions. The ability of methylation based classifiers to separate the three classes of material was assessed by ROC curve analyses. The best separation between normal and dyskaryotic samples was achieved by assessment of the L1/L2 CpGs at nucleotide positions 5600 and 5609 (AUC = 0.900, 95% CI: 0.793–1).ConclusionsThis study demonstrates the potential of quantification of HPV DNA methylation as a biomarker of cervical neoplasia. An algorithm considering methylation at specific L1/L2 CpGs appeared the most promising model
Interview with Alison Frank, September 25, 2009
No full textInterview Themes: How Frank chooses research topics (00:50)
Aspects of her training as a historian Frank found useful (07:00)
Books that have inspired and informed Frank's work (11:11)
On the role of area studies for scholarship on East-Central Europe (14:00)
"Internationalizing" the history of East-Central Europe (19:30)
Advice to young historians/scholars working on the region (22:11)Interview with Alison Frank, John L. Loeb Associate Professor of the Social Sciences at Harvard University. Interview conducted in Ithaca, NY on September 25, 2009. Professor Frank is the author of a number of articles and an excellent book on the oil industry in the Habsburg Monarchy entitled Oil Empire: Visions of Prosperity in Austrian Galicia. She is now working on a project on the coastline of Austria-Hungary.1_9lz5ekh
Veteran Law Students: Institutional Initiatives To Transform Their Law School Experiences
No full textPeer reviewe
Introduction: The Politics of Resilience and Recovery in Mental Health Care
No full textThe articles included in this special issue engage these themes across a number of national settings, institutional spaces, and empirical sites, from universities to mental health commissions, to national policy in an international context. They focus, especially, on Canada, Ireland and the United Kingdom, where recent and significant changes in mental health governance have relied heavily on the notions of recovery and resilience, often to questionable effect. They deal, as we have said, with some of the most central themes in social justice studies. As a collection, the articles help us think through some of the pressing political questions about social justice that have arisen with the adoption of the mantras of resilience and recovery in mental health governance
Negotiating the Culture of Resistance: A Critical Assessment of Protest Politics
No full textBoth for those within the movement and the public at large, the anti-globalization movement has become increasingly defined by large-scale protests such as those opposing the Free Trade Area of the Americas (FTAA) in Quebec City. Such events successfully render visible the strength of the movement, expose an emerging global elite, politicize neoliberal restructuring, and capture the media and public's attention. Yet the privileging of large-scale protest for advancing anti-globalist politics is increasingly being questioned both by those involved in the movement and by the Left in general.Peer reviewe
Human Papillomavirus DNA Methylation Predicts Response to Treatment Using Cidofovir and Imiquimod in Vulval Intraepithelial Neoplasia 3
No full textAbstractPurpose: Response rates to treatment of vulval intraepithelial neoplasia (VIN) with imiquimod and cidofovir are approximately 57% and 61%, respectively. Treatment is associated with significant side effects and, if ineffective, risk of malignant progression. Treatment response is not predicted by clinical factors. Identification of a biomarker that could predict response is an attractive prospect. This work investigated HPV DNA methylation as a potential predictive biomarker in this setting.Experimental Design: DNA from 167 cases of VIN 3 from the RT3 VIN clinical trial was assessed. HPV-positive cases were identified using Greiner PapilloCheck and HPV 16 type-specific PCR. HPV DNA methylation status was assessed in three viral regions: E2, L1/L2, and the promoter, using pyrosequencing.Results: Methylation of the HPV E2 region was associated with response to treatment. For cidofovir (n = 30), median E2 methylation was significantly higher in patients who responded (P ≤ 0.0001); E2 methylation &gt;4% predicted response with 88.2% sensitivity and 84.6% specificity. For imiquimod (n = 33), median E2 methylation was lower in patients who responded to treatment (P = 0.03; not significant after Bonferroni correction); E2 methylation &lt;4% predicted response with 70.6% sensitivity and 62.5% specificity.Conclusions: These data indicate that cidofovir and imiquimod may be effective in two biologically defined groups. HPV E2 DNA methylation demonstrated potential as a predictive biomarker for the treatment of VIN with cidofovir and may warrant investigation in a biomarker-guided clinical trial. Clin Cancer Res; 23(18); 5460–8. ©2017 AACR.</jats:p
Portrait of Alison Dolling, author and historian, Adelaide, 1978 [picture] /
No full textTitle devised by cataloguer from accompanying information.; "Dolling, Alison. Writes under Mary Broughton, Hazel de Berg collection. From Adelaide Festival, South Australia"--Compactus card.; Condition: Scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4764650; Conversation with Alison Dolling (Mary Broughton); located at; National Library of Australia Oral History collection ORAL TRC1/1067
Novel method for detection, typing, and quantification of human papillomaviruses in clinical samples
No full textWe report the development of a novel detection and typing methodology for human papillomaviruses (HPV) based on real-time PCR with the self-probing fluorescent primers known as Scorpions. This technique is quick, el simple, specific, sensitive, and capable of estimating viral load per cell. We report the results of over 100 typing reactions performed on cell lines, biopsies, and cervical cytobrush samples which, when compared to the current reference HPV detection and typing technique, present a kappa value of 0.89. We further report preliminary data suggesting a relationship between viral load per cell and grade of cervical disease
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