1,721,139 research outputs found
Unimanual and bimanual dexterity and its association with sensorimotor impairments in children with unilateral cerebral palsy
No full textChildren with unilateral cerebral palsy (uCP) experience sensorimotor impairments, compromising thedevelopment of manual dexterity which is crucial for performing everyday activities. Recently, the TynesidePegboard Test1 (TPT) was developed, to assess unimanual and bimanual dexterity specifically in childrenwith CP.
This study aimed
– to examine the psychometric properties of the TPT.
– to investigate the impact of sensorimotor impairments on unimanual and bimanual dexterity assessedwith the TP
Early motor, cognitive, language, behavioural and social emotional development in infants and young boys with Duchenne Muscular Dystrophy- A systematic review
No full textDuchenne Muscular Dystrophy (DMD) is an X-linked recessive disorder caused by mutations in the dystrophin gene. Deficiency of the dystrophin protein causes not only motor, but also cognitive, language, behavioural and social emotional problems. This is the first systematic review investigating five early developmental domains in boys with DMD between 0 and 6 years old. Interactions between different domains and links with mutation types and sites were explored. A systematic search was performed in PubMed, Web of Science and Scopus. An adapted version of the Scottish Intercollegiate Guidelines Network (SIGN) Checklists for case-control and cohort studies was used to evaluate quality. Fifty-five studies of high or acceptable quality were included. One was an RCT of level 1b; 50 were cohort studies of level 2b; and four were an aggregation of case-control and cohort studies receiving levels 2b and 3b. We found that young boys with DMD experienced problems in all five developmental domains, with significant interactions between these. Several studies also showed relationships between mutation sites and outcomes. We conclude that DMD is not only characterised by motor problems but by a more global developmental delay with a large variability between boys. Our results emphasise the need for harmonisation in evaluation and follow-up of young boys with DMD. More high-quality research is needed on the different early developmental domains in young DMD to facilitate early detection of difficulties and identification of associated early intervention strategies.The authors acknowledge KU Leuven Libraries - 2Bergen - D´esir´e Collen Learning Centre for tips and guidance on starting the review. Special thanks go to Lotte Schols, master’s student in Rehabilitation Sciences at Hasselt University, who contributed to the review process
Identifying bimanual motor control impairments in children with unilateral cerebrals palsy using the Kinarm End-point robot
No full textSensory function influences unimanual and bimanual dexterity in unilateral cerebral palsy
No full textThe recently developed Tyneside Pegboard Test (TPT) assesses both unimanual and bimanual dexterity in children with unilateral cerebral palsy (uCP). Our aim was to explore the TPT psychometric properties and the impact of sensorimotor impairments on unimanual and bimanual dexterity. Forty-nine children with uCP (mean age 9y8m, SD 1y11m, 30 males, 23 right-sided uCP) performed the unimanual and bimanual TPT providing task duration. For the psychometric properties, known-group validity was evaluated using ANCOVA (between MACS levels) and concurrent and construct validity with Spearman's correlations (r) with known and valid tests (Jebsen-Taylor Hand Function test (JTHFT), Assisting Hand Assessment (AHA), ABILHAND-Kids and Children's Hand Use Experience Questionnaire (CHEQ). The impact of sensorimotor impairments (spasticity, grip force, stereognosis and mirror movements) was investigated using multiple linear regression (α<0.05, R 2). Unimanual and bimanual dexterity differed between MACS levels (known-group validity) (p<0.001). The TPT tasks correlated to the JTHFT (concurrent validity, r=0.86-0.88), the AHA, ABILHAND-Kids and CHEQ (construct validity, r=-0.38-(-0.78)). Stereognosis was the main factor influencing all tasks (p<0.001, R²=37%-50%). Unimanual dexterity was further explained by grip strength (p<0.05, R 2 =8%-9%) and mirror movements in the more-impaired hand (p<0.05, R 2 =4%-8%), while bimanual dexterity was additionally explained by mirror movements in the more-impaired hand (p<0.01, R 2 =10%-16%) and spasticity (p=0.04, R 2 =5%). The TPT is a valid assessment to measure unimanual and bimanual dexterity. This study further highlights that stereognosis is the main determinant for unimanual and bimanual dexterity in children with uCP
Identifying bimanual motor control impairments in children with unilateral cerebrals palsy using the Kinarm End-point robot
No full textUnimanual and bimanual dexterity and its association with sensorimotor impairments in children with unilateral cerebral palsy
No full textChildren with unilateral cerebral palsy (uCP) experience sensorimotor impairments, compromising thedevelopment of manual dexterity which is crucial for performing everyday activities. Recently, the TynesidePegboard Test1 (TPT) was developed, to assess unimanual and bimanual dexterity specifically in childrenwith CP.
This study aimed
– to examine the psychometric properties of the TPT.
– to investigate the impact of sensorimotor impairments on unimanual and bimanual dexterity assessedwith the TP
Sensory function influences unimanual and bimanual dexterity in unilateral cerebral palsy
No full textThe recently developed Tyneside Pegboard Test (TPT) assesses both unimanual and bimanual dexterity in children with unilateral cerebral palsy (uCP). Our aim was to explore the TPT psychometric properties and the impact of sensorimotor impairments on unimanual and bimanual dexterity. Forty-nine children with uCP (mean age 9y8m, SD 1y11m, 30 males, 23 right-sided uCP) performed the unimanual and bimanual TPT providing task duration. For the psychometric properties, known-group validity was evaluated using ANCOVA (between MACS levels) and concurrent and construct validity with Spearman's correlations (r) with known and valid tests (Jebsen-Taylor Hand Function test (JTHFT), Assisting Hand Assessment (AHA), ABILHAND-Kids and Children's Hand Use Experience Questionnaire (CHEQ). The impact of sensorimotor impairments (spasticity, grip force, stereognosis and mirror movements) was investigated using multiple linear regression (α<0.05, R 2). Unimanual and bimanual dexterity differed between MACS levels (known-group validity) (p<0.001). The TPT tasks correlated to the JTHFT (concurrent validity, r=0.86-0.88), the AHA, ABILHAND-Kids and CHEQ (construct validity, r=-0.38-(-0.78)). Stereognosis was the main factor influencing all tasks (p<0.001, R²=37%-50%). Unimanual dexterity was further explained by grip strength (p<0.05, R 2 =8%-9%) and mirror movements in the more-impaired hand (p<0.05, R 2 =4%-8%), while bimanual dexterity was additionally explained by mirror movements in the more-impaired hand (p<0.01, R 2 =10%-16%) and spasticity (p=0.04, R 2 =5%). The TPT is a valid assessment to measure unimanual and bimanual dexterity. This study further highlights that stereognosis is the main determinant for unimanual and bimanual dexterity in children with uCP
Do mirror movements relate to hand function and timing of the brain lesion in children with unilateral cerebral palsy?
No full textAim: This study aimed to systematically map the severity of mirror movements in both hands in a prospective cohort of children with unilateral cerebral palsy, and to explore the relationship with hand function and brain lesion type. Method: Seventy-eight children were included (41 males, 37 females; age 9y 4mo, SD 3y 1mo, range 5-15y). Mirror movements were scored during three repetitive tasks following Woods and Teuber criteria. Strength, tone, Melbourne Assessment, Jebsen-Taylor test, and Assisting Hand Assessment were evaluated. Lesions were classified into malformations (n=5), periventricular (n=43), cortico-subcortical (n=22), and postnatally acquired lesions (n=8). Results: Significantly more mirror movements were observed in the non-paretic versus the paretic hand (p≤0.003). Higher mirror movement scores in the non-paretic hand significantly correlated with lower distal strength and lower scores on unimanual and bimanual assessments (r=0.29-0.41). In the paretic hand, significant differences were found between lesion types (p=0.03). Interpretation: The occurrence of mirror movements in the non-paretic hand seems related to hand function while mirror movements in the paretic hand seem more related to the lesion timing, whereby children with earlier lesions present with more mirror movements
The impact of brain lesion characteristics and the corticospinal tract wiring on mirror movements in unilateral cerebral palsy.
Full text linkMirror movements (MM) influence bimanual performance in children with unilateral cerebral palsy (uCP). Whilst MM are related to brain lesion characteristics and the corticospinal tract (CST) wiring pattern, the combined impact of these neurological factors remains unknown. Forty-nine children with uCP (mean age 10y6mo) performed a repetitive squeezing task to quantify similarity (MM-similarity) and strength (MM-intensity) of the MM activity. We used MRI data to evaluate lesion type (periventricular white matter, N = 30; cortico-subcortical, N = 19), extent of ipsilesional damage, presence of bilateral lesions, and damage to basal ganglia, thalamus and corpus callosum. The CST wiring was assessed with Transcranial Magnetic Stimulation (17 CSTcontralateral, 16 CSTipsilateral, 16 CSTbilateral). Data was analyzed with regression analyses. In the more-affected hand, MM-similarity and intensity were higher with CSTbilateral/ipsilateral. In the less-affected hand, MM-similarity was higher in children with (1) CSTcontra with CSC lesions, (2) CSTbilat/ipsi with PVL lesions and (3) CSTbilat/ipsi with unilateralized lesions. MM-intensity was higher with larger damage to the corpus callosum and unilateral lesions. A complex combination of neurological factors influences MM characteristics, and the mechanisms differ between hands
How do fine and gross motor skills develop in preschool boys with Duchenne Muscular Dystrophy?
No full textBackground: Boys with Duchenne Muscular Dystrophy (DMD) experience both fine and gross motor problems. Nowadays, early intervention focuses almost exclusively on gross motor skills. Aims: We aimed to explore early motor development in preschool boys with DMD and investigate the influence of cognition. Methods and procedures: Seventeen boys with DMD (11 months- 6 years) were compared to typically developing (TD) peers and followed-up with the Bayley Scales of Infant and Toddler Development (Bayley-III); Peabody developmental motor scales (PDMS-II) and Motor Function Measure (MFM-20). The longitudinal evolution of fine and gross motor skills was investigated using linear mixed effect models (LMM). Cognition was added to the LMM as a covariate. Outcomes and results: Preschool boys with DMD scored lower compared to TD peers on both fine and gross motor skills (p<0.001). The evolution of motor development was subscale-dependent. A significant influence of cognition was found on different subscales (p= 0.002-0.04). Conclusions and implications: Preschool boys with DMD do not achieve the same functioning level as TD boys. Cognition plays a crucial role in the evolution of motor skills. Our results suggest a shift to a broader psychomotor approach including both fine and gross motor skills, also considering the impact of cognition. What this paper adds?: Our study provides a detailed mapping of early fine and gross motor development in preschool boys with Duchenne Muscular Dystrophy (DMD) and describes the influence of cognition on both fine and gross motor skills. Preschool boys with DMD do not achieve the same functioning level compared to typically developing boys. They score significantly lower on both fine and gross motor skills. The evolution of fine and gross motor development was subscale-dependent e.g. a negative-positive evolution was seen for grasping skills, with a tipping point around the age of four; stationary scaled scores decreased followed by a stabilization around the age four to five and locomotion scaled scores remained stable over time. Finally, we also found that cognition plays a crucial role in the evolution of both fine and gross motor skills. These new insights in the evolution of early motor development could be of added value for future clinical trials in young boys with DMD. Subsequently, increased alertness to early symptoms, e.g. developmental delay, may advance the age of diagnosis, as well as associated early intervention.The authors acknowledge Silke Paulussen and Lotte Schols, master’s students in Rehabilitation Sciences at Hasselt University, who contributed to the data aqcuisition. This work was supported by the Stichting Marguerite-Marie Delacroix
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