6,290 research outputs found
Letter from Robert F. Martin, Surgeon, June 11, 1946
No full textWritten on official letterhead of the U.S. Department of Justice Immigration and Naturalization Service in Crystal City, Texas, Robert F. Martin, the Surgeon and Medical Officer in Charge writes in support of Mr. Harukichi Watanabe, who was employed as an orderly from November 9, 1944 through the date of this letter. He describes Watanabe as an ideal employee and recommends Watanabe for any work "in which he considers himself qualified."Collection of notes, articles, correspondence, photographs, and term papers collected by Yukio Mochizuki, a student at CSU Dominguez Hills, while researching Japanese American incarceration and Japanese Peruvian internment during World War II
[Recombinant proteins as therapeutic compounds in clinical oncology]
No full textThe in vitro production of recombinant protein molecules has fostered a tremendous interest in their clinical application for treatment and support of cancer patients. Therapeutic proteins include monoclonal antibodies, interferons, and haematopoietic growth factors. Clinically established monoclonal antibodies include rituximab (targeting CD20-positive B-cell lymphomas), trastuzumab (active in HER-2 breast and gastric cancer), and bevacizumab (blocking tumor-induced angiogenesis through blockade of vascular-endothelial growth factor and its receptor). Interferons have lost much of their initial appeal, since equally or more effective treatments with more pleasant side effects have become available, for example in chronic myelogenous leukaemia or hairy cell leukaemia. The value of recombinant growth factors, notably granulocyte colony stimulating factor (G-CSF) and erythropoietin is rather in the field of supportive care than in targeted anti-cancer therapy. Adequately powered clinical phase III trials are essential to estimate the true therapeutic impact of these expensive compounds, with appropriate selection of clinically relevant endpoints and sufficient follow-up. Monoclonal antibodies, interferons, and growth factors must also, and increasingly so, be subjected to close scrutiny by appropriate cost-effectiveness analyses to ensure that their use results in good value for money. With these caveats and under the condition of their judicious clinical use, recombinant proteins have greatly enriched the therapeutic armamentarium in clinical oncology, and their importance is likely to grow even further
Salient clinical features of lymphoma and related lymphoproliferative disorders
No full textThe literature on malignant lymphomas has grown to an extent which is hardly palatable for general practitioners and non-lymphoma aficionados. Nevertheless some lymphomas exhibit typical clinical and radiological features which permit to suspect the correct histopathological diagnosis even before a pathology report becomes available. The present article points out such "case vignettes" of particular types of malignant lymphoma.Die Literatur über maligne Lymphome ist unübersichtlich geworden, sogar für Spezialisten. Viele Hausärzte oder Internisten nähern sich dem Thema mit dem unguten Gefühl, als „einfache“ Kliniker ohnehin nicht mithalten zu können. Diese Einschätzung ist nur bedingt richtig. Auch wenn die Pathologie und die Molekularbiologie neue Daten zu diesen Tumoren in der Literatur parkiert haben, so können wir mit einfachen klinischen Mitteln und Routinelabortests sowie mit bildgebenden Verfahren durchaus „typische Vignetten“ einzelner maligner Lymphome finden
Benefits of a Classification Scheme of Granitic Pegmatites Based on Petrogenetic Considerations.
No full textOral presentation-
Communicating author: Martin RF
WHY IS AMAZONITIC K-FELDSPAR AN EARMARK OF NYF-TYPE GRANITIC PEGMATITES?
No full textOral presentation- Communicating author: Martin R
Tumor suppressor genes in myeloid differentiation and leukemogenesis
No full textTumor suppressor genes, such as p53, RB, the INK4-ARF family and PML, suppress malignant transformation by regulating cell cycle progression, ensuring the fidelity of DNA replication and chromosomal segregation, or by inducing apoptosis in response to potentially deleterious events. In myeloid leukemia, hematopoietic differentiation resulting from highly coordinated, stage-wise expression of myeloid transcription and soluble signaling factors is disrupted leading to a block in terminal differentiation and uncontrolled proliferation. This virtually always involves functional inactivation or genetic disruption of one or several tumor suppressor genes in order to circumvent their checkpoint control and apoptosis-inducing functions. Hence, reactivation of tumor suppressor gene function has therapeutic potential and can possibly enhance conventional cytotoxic chemotherapy. In this review, we focus on the role of different tumor suppressor genes in myeloid differentiation and leukemogenesis, and discuss implications for therapy
"The day of the great writer is gone for ever": Author surrogacy in Martin Amis’s Money and J.M. Coetzee’s Summertime.
No full textThis study focuses on the use of author surrogacy in the novels Money: A Suicide Note by Martin Amis and Summertime: Scenes from Provincial Life by J.M. Coetzee. It addresses the connection between their use of author surrogacy and their comments on what scholars classify as the postmodern cultural condition. Both authors have written themselves into their novels with a different purpose but both used strikingly similar themes to incorporate this purpose, although the stress on these themes varies. Authorial power, the distinction between the real and the imagined, and the fading line between high- and lowbrow culture are examples of the topics discussed in this study with regards to author surrogacy and the postmodern cultural condition. This study concludes that, through their use of author surrogacy, J.M. Coetzee mainly aims to critique, while Martin Amis satirises postmodern culture.
Keywords: Amis, author surrogacy, authorial power, Coetzee, fact-fiction distinction, high- and lowbrow culture, postmodern cultural condition
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