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Echoes of counterculture in Stefano Benni's humour
No full textStefano Benni’s first novel, Terra! (1983) - a sci-fi spoof and a satire of contemporary life - set the trend for his subsequent fiction. Blending fantasy, pop culture, literary pastiche and current affairs, Benni’s political and social satires have been nationally and internationally successful. Less known yet crucial to the understanding of his fiction as well as to his use of humour are his earlier writings and their engagement with social and political issues. This study aims to show that the roots of Benni’s humour, with its coarse language, puns, pastiche and mocking tone, are to be found in the student spirit and political protest of the 1970s. Adopting an interdisciplinary approach which draws on social history as well as structuralist methods of literary analysis, it argues that the subtle rhetorical strategies employed, as well as the strong underlying political intent, militate against the dismissive label of ‘popular fiction writer’ attached to him by some critics
Democrazia protetta
No full textIl testo si concentra sul modo tradizionale di protezione della democrazia, ossia sul divieto di partiti antisistema tra Costituzioni nazionali e giurisprudenza della Corte di Strasburgo per rilevare che in realtà, quasi ovunque, si sono preferiti e sono risultati efficaci strumenti più flessibili, come le convenzioni costituzionaliThe text focuses on the traditional way of protection of democracy , namely the prohibition of anti-system parties, in national constitutions and in case law of the Strasbourg Court to point out that in fact , almost anywhere , are preferred and effective more flexible instruments , such as the conventions of the Constitution
Microdynamics of water and ion homeostasis in the brain: role of aquaporins and ion channels of astroglial cells
No full textThere is no abstract since is a book chapte
Who is the author of the 1876 Stefano manuscript?
No full textFor over one hundred years the Stefano manuscript was a private document in the possession of the Baccich family and descendants. It told a story of the 1875 Stefano shipwreck as narrated by the shipwreck survivor and the founding family patriarch Miho Baccich. In these circumstances the question of authorship of the manuscript was immaterial and did not arise as an issue. However, with the publication of the manuscript the author‟s name, or names, need to be formally attributed to it. It turns out that this is not such a clear-cut matter.
As we shall see, all informed sources attributed the authorship, and the ownership, of the manuscript to Miho Baccich. But the manuscript itself was written by Canon Stjepan Skurla – a priest from Miho‟s hometown of Dubrovnik. The question then arises: should Skurla also be considered as an author of the manuscript, or, even as the sole author (as some would have it)
Correction: Ferroni et al. A Hyaluronan-Based Scaffold for the in Vitro Construction of Dental Pulp-Like Tissue. Int. J. Mol. Sci. 2015, 16, 4666–4681
No full textIn the original publication [...
Fashion Culture: Power In Fashion with Stefano Tonchi and Grazia d'Annunzio
No full textStefano Tonchi, global chief creative officer for L’Officiel Group, and Grazia d’Annunzio, former deputy director of Vogue Italia, discuss the power of military uniforms and their influence on high fashion. Tonchi is co-author of the book "Uniform: Order and Disorder.
Water transport between CNS compartments: functional and molecular interactions between aquaporins and ion channels
No full textThe physiological ability of the mammalian CNS to integrate peripheral stimuli and to convey information to the body is tightly regulated by its capacity to preserve the ion composition and volume of the perineuronal milieu. It is well known that astroglial syncytium plays a crucial role in such process by controlling the homeostasis of ions and water through the selective transmembrane movement of inorganic and organic molecules and the equilibration of osmotic gradients. Astrocytes, in fact, by contacting neurons and cells lining the fluid-filled compartments, are in a strategic position to fulfill this role. They are endowed with ion and water channel proteins that are localized in specific plasma membrane domains facing diverse liquid spaces. Recent data in rodents have demonstrated that the precise dynamics of the astroglia-mediated homeostatic regulation of the CNS is dependent on the interactions between water channels and ion channels, and their anchoring with proteins that allow the formation of macromolecular complexes in specific cellular domains. Interplay can occur with or without direct molecular interactions suggesting the existence of different regulatory mechanisms. The importance of molecular and functional interactions is pinpointed by the numerous observations that as consequence of pathological insults leading to the derangement of ion and volume homeostasis the cell surface expression and/or polarized localization of these proteins is perturbed. Here, we critically discuss the experimental evidence concerning: (1) molecular and functional interplay of aquaporin 4, the major aquaporin protein in astroglial cells, with potassium and gap-junctional channels that are involved in extracellular potassium buffering. (2) the interactions of aquaporin 4 with chloride and calcium channels regulating cell volume homeostasis. The relevance of the crosstalk between water channels and ion channels in the pathogenesis of astroglia-related acute and chronic diseases of the CNS is also briefly discussed
Intracellular Na+ inhibits volume-regulated anion channel in rat cortical astrocytes
No full textAccumulating evidence indicates that increased intracellular Na+ concentration ([Na+]i) in astroglial cells is associated with the development of brain edema under ischemic conditions, but the underlying mechanisms are still elusive. Here, we report that in primary cultured rat cortical astrocytes, elevations of [Na+]i reflecting those achieved during ischemia cause a marked decrease in hypotonicity-evoked current mediated by volume-regulated anion channel (VRAC). Pharmacological manipulations revealed that VRAC inhibition was not due to the reverse mode of the plasma membrane sodium/calcium exchanger. The negative modulation of VRAC was also observed in an astrocytic cell line lacking the predominant astrocyte water channel aquaporin 4, indicating that [Na+]i effect was not mediated by the regulation of aquaporin 4 activity. The inward rectifier Cl- current, which is also expressed by cultured astrocytes, was not affected by [Na+]i increase. VRAC depression by high [Na+]i was confirmed in adult astrocytes, suggesting that it was not developmentally regulated. Altogether, these results provide the first evidence that intracellular Na+ dynamics can modulate astrocytic membrane conductance that controls functional processes linked to cell volume regulation and add further support to the concept that limiting astrocyte intracellular Na+ accumulation might be a favorable strategy to counteract the development of brain edema
Introduzione [a I cartolari del notaio Stefano di Corrado di Lavagna]
No full textSaggio introduttivo all’edizione dei frammenti dei protocolli del notaio Stefano di Corrado di Lavagna nel quale viene fatta l’analisi codicologica dei frammenti e si ricostruisce la biografia del notaio. Vengono inoltre esaminate la tipologia dei documenti, le tecniche redazionali del notaio e l’organizzazione burocratica della Chiesa genovese nella seconda metà del secolo XIII.
Introduction essay to the edition of the fragments of the protocols of the notary Stefano di Corrado of Lavagna in which the analysis of the codex fragments and reconstructs the biography of the notary is made by the author. She also examined the types of documents, the technical drafting of the notary and the bureaucratic organization of the Church of Genoa in the second half of the thirteenth century
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