162 research outputs found
Neoplasie ereditarie: ruolo dei geni BRCA1 e BRCA2 nei carcinomi eredo-familiari di mammella e ovaio
No full textConcetta Zuccarello cooking in the family kitchen on Bloomfield Avenue.
No full textConcetta Zuccarello, an immigrant from Sicily, in the familiy kitchen 218 Bloomfield Ave., Cold Water Flat. Concetta is grandmother of Josephine Zuccarello, wife of photographer. Both 1910 and 1911 listed as a date for photograph
Periosteum derived stem cells for regenerative medicine proposals: boosting current knowledge
No full textNanoparticle-mediated delivery of IL-2 to T follicular helper cells protects BDF1 mice from lupus-like disease
No full textWe recently reported that poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) loaded with interleukin (IL)-2 and targeted to T cells inhibited the development of lupus-like disease in BDF1 mice by inducing functional T regulatory cells (Tregs). Here we show that the protection from disease and the extended survival of BDF1 mice provided by IL-2-loaded NPs targeted to T cells is not only due to an induction of Tregs but also contributed by an inhibition of T follicular helper (T(FH)) cells. These results identify a dual protective activity of IL-2 in the control of lupus autoimmunity, namely the inhibition of effector T(FH) cells, in addition to the previously known induction of Tregs. This newly recognized activity of IL-2 delivered by NPs can help better explain the beneficial effects of low-dose IL-2 immunotherapy in systemic lupus erythematosus (SLE), and might be considered as a new strategy to slow disease progression and improve outcomes in lupus patients
“L’Animo ciascuna sua passion sotto el contrario manto ricopre”. Guichardin et les passions “italiennes” dans le livre I des Essais
No full textThe article analyzes the relationship between history and the passions thorough the borrowings from the Storia d’Italia. Guicciardini by Francesco Guicciardini. Guicciardini's influence on the author of the Essais seems to extend to both the content and the form of the borrowed texts (their style, description techniques, and so on), and indeed to the treatment of the passions described. The analysis of the examples borrowed from Guicciardini in Book I fo the Essais leads to some initial conclusions ; although, there is further research yet to be done.L’étude analyse le rapport entre l’Histoire et les passions à travers les emprunts à la Storia d’Italia de Guichardin. L’influence de Guichardin sur l’auteur des Essais semble toucher tant le contenu des textes empruntés que la forme (style, modalités de la description, etc.), ainsi que le traitement des passions décrites. L’analyse des exemples empruntés à Guichardin dans le livre I des Essais permet de tirer les premières conclusions ; cependant, la recherche aurait besoin d’être poursuivie
"J'ay un dictionnaire tout à part moy": la pratique du 'dictionnaire' chez Montaigne écrivain italien
No full textThe article focuses on the writing of the italian part of Montaigne's "Journal the voyage". The author has maybe read or used grammar books, dictionaries or linguistic works to learn how to write correctly. The article gives a general overview of such linguistic production in the period of Montaigne's travel to Italy (1580-81)
La formazione filosofica di Orazio nella lettura degli esegeti antichi
No full textIn una delle Vite di Orazio riportate dai manoscritti che conservano gli scolii antichi alla sua opera si legge che il poeta, in seguito alla formazione culturale romana, si sarebbe recato ad Atene per il tradizionale ‘viaggio d’istruzione’ al fine di apprendere la filosofia; tale insegnamento sarebbe stato innanzitutto epicureo. L’elemento costituisce una novità rispetto a quanto riportato da Svetonio, con cui le vite dei manoscritti presentano in generale evidenti affinità. L’autore della Vita riferisce inoltre che Orazio avrebbe ammesso di essere epicureo 'in principio carminis' ritenendo d’altronde felice chi agisce secondo il proprio istinto, chi considera la 'voluptas' il sommo bene. Nella lettura di un commentatore tardoantico ne derivava pertanto che Orazio fosse epicureo in questa prospettiva vengono così lette le Satire e anche - ma in maniera differente, come l’analisi mette in luce - le Epistole.One of the Lives of Horace in the manuscripts preserving the ancient scholia to his work records that the poet, following the Roman cultural education, would have gone to Athens for the traditional ‘educational journey’ in order to learn philosophy; this teaching would have been mostly epicurean. This constitutes a novelty with respect to what is reported by Suetonius, with which the lives of manuscripts generally have evident affinities. The author of the Life also says that Horace would have admitted to being an epicurean in principio carminis, considering happy who acts according to his own instinct and looks at voluptas as the highest good. Thus, in the reading of the late commentator, Horace was epicurean and the Satires and also - but in a different way, as clarified in the analysis - the Epistles are evaluated in this perspective
Selective laser sintering manufacturing of polycaprolactone bone scaffolds for applications in bone tissue engineering
No full textNitric oxide and human sperm motility: an immunohistochemical study
No full textDefective sperm function is a common cause of human male infertility. Human spermatozoa are very susceptible to oxidative stress, probably because they contain high levels of polyunsaturated fatty acids and are exposed to ROS produced by contaminating neutrophils or by the spermatozoa themselves. In addition, due to the cytoplasm scarcity, they lack an adequate reserve of antioxidant enzymes. It has been previously shown that human spermatozoa produce nitric oxide (NO) as well as superoxide anion and consequently peroxynitrite, which can rapidly react with proteins, lipids, and nucleic acids. NO is a short-lived free radical produced by three isoforms of NO synthase (NOS): endothelial (eNOS), neuronal (nNOS), and inducible (iNOS), which are responsible for the conversion of L-arginine to L-citrulline and NO. NO plays an important role in sperm physiology, although at high concentrations it could lead to cytotoxicity accompanied by decreased sperm motility. In recent studies it has been evidenced the presence of a significant negative linear correlation between NO concentration and sperm motility, as well as between peroxynitrite production and the kinetic features of spermatozoa. It has been previously demonstrated that the spermatozoa of fertile men express both eNOS and nNOS, which appear to be involved in sperm motility, metabolism, capacitation and acrosome reaction. However, the specific role of NOS isoforms in gametes is not well understood, even if iNOS seems to negatively affect the sperm function through the production of large amounts of NO, and consequently the nitration of protein tyrosine by peroxynitrite. The aim of the present study was to assess the presence and localization of NOS isoforms in human spermatozoa isolated from controls and asthenozoospermic infertile patients, by means of immunohistochemical techniques, in order to characterize the pattern of NOS expression and to evaluate the correlation with sperm function. In addition we studied the immunoexpression of citrulline, to achieve the microscopic visualization of NOS catalytic activity, and nitrotyrosine, since the protein tyrosine nitration represents a shift from the physiological role of NO toward pathogenetic pathways. The main results of our study are that the immunohistochemical expression of constitutive NOS isoforms is lower in the asthenozoospermic group, while the immunoexpression of iNOS and nitrotyrosine is higher in comparison with normozoospermic fertile subjects, thus suggesting a possible pathogenetic role of NO in the reduction of sperm motility
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