131,901 research outputs found
Profilo clinico-epidemiologico della sclerosi multipla nella provincia di Ferrara
No full textStudio descrittivo sulla prevalenza e sull'incidenza della sclerosi multipla nella provincia di Ferrara, Italia
Materialidad difusa. Prácticas de diseño y tendencias. Introduction by the School of Design of Politecnico di Milano
No full textIn the contemporary panorama of design, materials are gained an important
role. We are the witnesses of an incredible acceleration in the evolution of the design
practices and processes related to materials developments and applications.
In the present issue, we want to introduce and formalized the concept of “diffuse
materiality” for describing these significant changes in the field of materials for design.
In fact, all the classes of materials are transforming into something different: plastics
become bio, composite materials change into smart, agricultural wastes turn into growing
materials and those of industrial production in advanced materials, and the organic
materials become the border of the future design.
For defining the concept of diffuse materiality we focused on the European context, and
we collected various contributions from scholars describing their personal approach to
materials. In the following introduction, there is a short description of all these articles
Matematica e idraulica a Ferrara nell'età del Tasso
No full textAttraverso un'ampia documentazione inedita vengono illustrati i principali e più impegnativi problemi idraulici del Ducato di Ferrara nel secolo XVI che ebbero come conseguenza lo sviluppo di competenze e conoscenze sia teoriche che pratiche in questo ambito disciplinare nel tessuto culturale ferrarese
Statuti di Comacchio, sec. XV
No full textSupplemento al volume 68 degli Atti dell'Accademia delle Scienze di Ferrara, 168° anno accademico 1990-199
L'Università degli scolari di medicina e d'arti dello Studio ferrarese (sec. XV- XVIII)
No full textpubblicazione ufficiale nell'ambito delle celebrazioni dell'Università degli Studi di Ferrara per il VI centenario della sua fondazione (1391-1991
Personal experience on antibiotic resistance in Ferrara
No full textClinical relevance of antibiotic resistance among propionibatteria carried by acne patients in Ferrara (Italy) is discusse
Amazonian plants from ethnomedicine to biotechnology through pharmaceutical biology approaches: a PhD experience in connecting forest with laboratory
No full textThe South american Natives, Shuar and Achuar people and their ethnomedical culture constitute the
background subject of the Phd research, performed both in Ecuador (Salesian Politechnic University,
Quito), and in Italy (Pharmaceutical biology labs, University of Ferrara). Based on ethnomedical
responses, Piper aduncum, Maytenus macrocarpa, Schinus molle, Tecoma stans and Eugenia hallii were
chosen as amazonian plant species subject of the research.
AIMS
The research has been focused on:
− checking the presence of endophytic fungi in plants;
− isolating and subculturing pure endophytic strains;
− checking the biotransformation capacity of the isolated endophytes on pure compounds; the most
performing endophytes were also tested on phytocomplexes and pure chemicals obtained by the
plant from which the fungi were isolated;
− phytochemical characterization and bioactivity assays of plant extracts: P. aduncum.
−
METHODS
Biotransformations. Fresh aerial plant parts were properly washed in sanitizing solutions and in vitro
cultured using adequate solid media to isolate endophytes. (+/-)-cis-bicyclo[3.2.0]hept-2-en-6-one,
acetophenone, 1-indanone, 2-furyl methyl ketone, 2-methylcyclopentanone, 2-methylcyclohexanone, 2-
methoxycyclohexanone were chosen as substrate model for biotransformations. The cultures were
sampled after 1, 3, 7, 10 days of culturing, and ethyl acetate extracted to verify by GC-MS the presence of
possible biotransformation products. Biotransformations were also checked on P. aduncum whole
essential oil and on dillapiol, cis-ocimene, piperitone, (-)-terpinen-4-ol as most abundant chemicals.
Chemical fingerprinting of P. aduncum essential oil. Steam distillation was adopted to obtain the essential
oil, then characterized by GC-MS, NMR analyses.
In vitro bioassays of P. aduncum essential oil. Antimicrobial activities were checked in vitro using proper
agarized media to reach MIC. Antioxidant capacities were checked through DPPH test, ABTS and
photochemiluminescence assays. Born's turbidimetric method and Writhing test were respectively
adopted to check platelet-aggregation and anti-nociceptive properties. Mutagenic, antimutagenic
properties and toxicity were assayed using classical and modified Ames test.
MAIN RESULTS
364 fungal strains were in vitro isolated. Among all, 5 strains performed biotransformations on
acetophenone to (S)-1-phenylethanol, with important yields (78-97%) and enantiomeric excess (78-
100%). Three strains gave also phenols probably by enzymatic reactions (Baeyer-Villiger oxidations). 15
fungal strains gave the lactones (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one and (-)-(1R,5S)-3-
oxabicyclo[3.3.0]oct-6-en-2-one from (+/-)-cis-bicyclo[3.2.0]hept-2-en-6-one, probably as result of
monooxygenase activation. Phytochemical characterization of P. aduncum essential oil has evidenced
dillapiol as the most abundant terpene, followed by cis-ocimene, piperitone and terpinen-4-ol. Only cisocimene
and piperitone gave several biotransformation products through dehydrogenation and
hydroxylation reactions. The essential oil has evidenced non-mutagenic properties and interesting
antifungal and antioxidant activities.
CONCLUSIONS
Several endophytic fungal strains from Amazonian plants were isolated and checked for
biotransformations on pure chemicals and on P. aduncum essential oil. Data obtained will be useful for
possible following patents about micro-organisms able to transform pharmaceutically interesting
chemicals. Taxonomical characterization of the most performing fungal strains is still in progress. P.
aduncum essential oil can be considered genotoxically safe and provides interesting antifungal and
antioxidant properties, supporting its ethnomedical use as cicatrising and disinfectant crude drug and
suggesting an extension of its employ as preservative ingredient
[Descrizioni bibliografiche nel catalogo della mostra 'Natura naturata. Capolavori librari dell'Università degli Studi di Ferrara']
No full textCatalogo dell'omonima mostra tenuta presso la Biblioteca chimico-biologica S. Maria delle Grazie dell'Università di Ferrara (19 aprile -1 maggio 2019)
Self healing capacity of concrete with crystalline additives: natural vs. accelerated exposure conditions
No full textThe presence of cracks may significantly affect the life-cycle of structures, as a results of its influence on the designed structural response vs. persistent or even severe accidental load and exposure conditions, when requested. Repairing damaged concrete in existing structures needs important investments to recover the pristine level of serviceability and extend their designed service life. In this respect, the ability of cementitious composites to \u93self-repair\u94 the cracks, because of autogenous or suitably engineered mechanisms, is a challenging opportunity, making concrete more and more attractive in future sustainable developments of civil engineering. In this study a methodology will be presented to assess the aforementioned capacity, based on three point bending tests on un-cracked and pre-cracked beams, upon exposure to suitable environmental conditions. The paper will focus on the difference between accelerated exposure, in a climate chamber, and \u93natural conditioning\u94 in air; comparison with immersion in water will also be performed
Epidemiologic approach to huntington's disease in northern Italy (Ferrara area)
No full textAs part of a multidisciplinary study program, an epidemiological descriptive survey was carried out in the province of Ferrara, northern Italy. The temporal trend of Huntington chorea (HC) in the last century (1871-1987) was determined in the study area, and the patients and subjects at risk were identified with the aim of creating genetic advisory councils offering preventive interventions to eliminate the disease. The final study population consisted of 10 unrelated families with HC and 47 HC cases who lived in the province of Ferrara in the survey period. The estimate of the prevalence rate varied over the time period considered between 3.09 and 0.36 cases per 100,000 inhabitants. The temporal trend was characterized by increasing and decreasing phases, reflecting the incidence (varying between 0.20 and 0.00 annual cases per 100,000 inhabitants) and mortality (varying between 0.21 and 0.00 annual deaths per 100,000 inhabitants) rates. This trend shows that the frequency of HC in the study area was not stable. It was characterized by a cyclic course with a period of about 50 years. In the recent decades of the study, the incidence and the prevalence rates showed a relative increase. Thus, HC persists in the Ferrara population despite a greater public awareness and the recent lower birth rate. A new peak of prevalence is likely in the near future
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