78 research outputs found
LincRNA Expression Discriminates Cytogenetic Subtypes In B-Lymphoblastic Leukemia and Plays a Functional Role In Leukemia Cell Survival
No full textScenography of Heritage: An Urban think Tank
No full textAs a result of long time colonisation and trade, the city of Semarang in Indonesia has a large stock of built heritage that share a history with the Netherlands. The Dutch colonial buildings, left to decay have become a backdrop for tourists and feed into the 'insta culture' sweeping the current decade. At the same time the city suffers deeply from a neglected river, Kali Semarang, and lack of accessibility to water. How can we confront the current issues of water, waste and neglected built heritage? The idea that we are all connected, spatially, politically, environmentally and by memory and so on are confronted while finding solutions to empower the communities, and provide better access to a basic human right; water.Architecture, Urbanism and Building Sciences | Heritage & Architectur
Supercapacitor assisted low dropout regulators (SCALDO) with reduced switches: A new approach to high efficiency VRM designs
No full textSupercapacitor assisted low dropout (SCALDO) regulator is a new approach to develop high efficiency DC-DC converters with supercapacitors used for energy recovery. One limitation in these topologies is that in some configurations a large number of low-speed switches are required. If the SCALDO technique is adapted to build voltage regulator modules (VRM), it is necessary to reduce number of switches combined with a high current capable LDO. A new topology-variation with less number of switches can be achieved by reconfiguring the original SCALDO and adding an extra LDO to the circuit. The paper presents a summary of some preliminary work, and experimental results for a 2.5V proof of concept-prototype
Adverse Childhood Experiences and Diet Quality in young African American women: A descriptive analysis of a community-based survey
No full textBackground: High exposure to ACEs (4+) is associated with an increased risk of CVD and poorer health behaviors in adulthood. However, evidence is limited in young adults2-4. Aims. To describe diet quality and exposure to ACEs in AA women aged 18-35 years old. Methods: Descriptive analysis of survey data collected in self-identified AA women aged 18-35 (N=512). Assessments included self-reported ACE exposure (4+ indicates high risk) and WELL Diet score (range 0-120; higher score = better diet quality). Results: XX% of our sample reported high ACEs exposure. Mean Well Diet score was xx (sd:) out of 120. Further research is warranted.
2Su, S., Jimenez, M. P., Roberts, C. T., & Loucks, E. B. (2015). The role of adverse childhood experiences in cardiovascular disease risk: a review with emphasis on plausible mechanisms. Current cardiology reports, 17(10), 88. https://doi.org/10.1007/s11886-015-0645-1
3Nikulina, V., & Widom, C. S. (2014). Do race, neglect, and childhood poverty predict physical health in adulthood? A multilevel prospective analysis. Child abuse & neglect, 38(3), 414–424. https://doi.org/10.1016/j.chiabu.2013.09.007
4Sonu, S., Post, S., & Feinglass, J. (2019). Adverse childhood experiences and the onset of chronic disease in young adulthood. Preventive medicine, 123, 163–170. https://doi.org/10.1016/j.ypmed.2019.03.03
RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation
No full textPosttranscriptional control of gene expression is important for defining both normal and pathological cellular phenotypes. In vitro, RNA-binding proteins (RBPs) have recently been shown to play important roles in posttranscriptional regulation; however, the contribution of RBPs to cell specification is not well understood. Here, we determined that the RBP insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is specifically overexpressed in mixed lineage leukemia-rearranged (MLLrearranged) B-acute lymphoblastic leukemia (B-ALL), which constitutes a subtype of this malignancy associated with poor prognosis and high risk of relapse. IGF2BP3 was required for the survival of B-ALL cell lines, as knockdown led to decreased proliferation and increased apoptosis. Enforced expression of IGF2BP3 provided murine BM cells with a strong survival advantage, led to proliferation of hematopoietic stem and progenitor cells, and skewed hematopoietic development to the B cell/myeloid lineage. Cross-link immunoprecipitation and high throughput sequencing uncovered the IGF2BP3-regulated transcriptome, which includes oncogenes MYC and CDK6 as direct targets. IGF2BP3 regulated transcripts via targeting elements within 3' untranslated regions (3'UTR), and enforced IGF2BP3 expression in mice resulted in enhanced expression of Myc and Cdk6 in BM. Together, our data suggest that IGF2BP3-mediated targeting of oncogenic transcripts may represent a critical pathogenetic mechanism in MLL-rearranged B-ALL and support IGF2BP3 and its cognate RNA-binding partners as potential therapeutic targets in this diseas
ADAPTING BOTTOM OF PYRAMID PEOPLE FOR A MOBILE LEARNING ENVIRONMENT: A MOTIVATIONAL PERSPECTIVE
No full textA Study of Indian and US Trademark Law Relating to the Effect of ‘Non-Use’ of a Trademark
No full text236-243This paper surveys the operation of user requirements and the effect of non-use of trademarks in USA and India and examines what constitutes ‘use’ of a trademark and then also examines non-use and its effects. Even though proof of use is not required in many countries for either registration or renewal it is critical for maintaining trademark rights. Generally, the right to exclusive use of a mark grows out of its use in connection with an established business or trade. The user who first appropriates the mark obtains an enforceable right to exclude others from using it, as long as the initial appropriation and use are accompanied by an intention to continue exploiting the mark commercially. Accordingly, failure to use the mark can result in a loss of that right and trademarks may be attacked on the ground of abandonment or non-use. Almost all countries in the world permit a third party to petition the Trademark Office to cancel a registration for non-use. The author briefly examines the position laid own in the Paris Convention and TRIPS Agreement with regard to the issue of non-use. However, it has to be noted that whereas the legal position regarding the issue is pretty much settled in USA, India is still at the nascent stages of development of relevant law
Phenotypic and genotypic landscape of antibiotic resistance through One Health approach in Sri Lanka : A systematic review
No full textFor the purpose of open access, the corresponding author's affiliated institute (University of Aberdeen) has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.Peer reviewe
Identifying the Mental Health Needs of Adults with Type 1 Diabetes
No full textBackground: People with type 1 diabetes (T1D) are at an increased risk for mental illness, which can adversely affect diabetes self-care and glycemic control. Though effective medications and behavioral interventions exist for the management of mental disorders, implementation is low and interventions for patients with T1D largely target children and adolescents. This study aimed to explore the mental health needs of adults with T1D and how those needs may change over the life course.
Methods: We conducted focus group discussions (n=5) with adults diagnosed with T1D who have sought mental health care and/or been diagnosed with a mental illness. Focus group transcripts were analyzed using a rapid qualitative analytic approach where templates summarizing the main discussion topics were compared to identify shared themes related to mental health across participants and life transitions.
Results: Participants identified a range of mental health conditions that stem from living with T1D, with the acknowledgement that common mental disorders are inevitable for people living with this complex and life-threatening condition. Disordered eating, obsessive compulsive disorder, post-traumatic stress, and hypervigilance were reported as common experiences within the initial years of being diagnosed and learning to manage T1D, adolescence and emerging adulthood, and following critical life events (pregnancy), while depression, anxiety, distress, and burnout were reoccurring across the life course. Groups advocated for improved mental health screening among people with T1D, improved provider education on how to counsel and support the mental health of patients with T1D, and to recognize the unique mental health needs of patients with type 1 versus type 2 diabetes and to tailor mental health promotion interventions accordingly.
Conclusions: Challenges of living with T1D vary across the life course and contribute to poor mental health, with certain periods necessitating tailored behavioral support and mental health intervention.
Keywords: mental health, diabetes, health promotio
Fitting regression models using the LINEX loss function: Properties and applications
No full textResearchers in statistical shape analysis often analyze outlines of objects. Even though these contours are infinite-dimensional in theory, they must be discretized in practice. When discretizing, it is important to reduce the number of sampling points considerably to reduce computational costs, but to not use too few points so as to result in too much approximation error. Unfortunately, determining the minimum number of points needed to achieve sufficiently approximate the contours is computationally expensive. In this paper, we fit regression models to predict these lower bounds using characteristics of the contours that are computationally cheap as predictor variables.
However, least squares regression is inadequate for this task because it treats overestimation and underestimation equally, but underestimation of lower bounds is far more serious. Instead, to fit the models, we use the LINEX loss function, which allows us to penalize underestimation at an exponential rate while penalizing overestimation only linearly. We present a novel approach to select the shape parameter of the loss function and tools for analyzing how well the model fits the data. Through validation methods, we show that the LINEX models work well for reducing the underestimation for the lower bounds.
The LINEX regression model works well in reducing the underestimation with an appropriate shape parameter value. Our study does not focus on model selection in regression analysis under the LINEX loss function. The main goal is to develop the regression model using the Ordinary Least Squares (OLS) regression model as the basic model, which will enhance the prediction performance by reducing the underestimation or overestimation by using the LINEX loss function. Since there is no closed-form solution for LINEX estimators, from the simulation study, we show that regardless of the error distribution, it provides a bias estimator. We also show that increasing the shape parameter value in a large amount will not reduce the underestimation a lot after some point. Finally, we illustrate the usage of the LINEX loss function to reduce the underestimation in data fitting for dynamical models rather than using the squared error loss function.Embargo status: Restricted until 09/2027. To request the author grant access, click on the PDF link to the left
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