133 research outputs found
Design and evaluation of special drug delivery techniques of poorly soluble drug for enhancing skin permeability
No full textPh. D.Includes bibliographical referencesIncludes vitaby Indrajit Ghos
Surface chemistry of carbon nanoparticles functionally select their uptake in various stages of cancer cells
No full textEmbargo set by: Colleen Fallaw for item 102762
Lift date: 2019-08-10T21:27:21Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemRelationship of the surface physicochemical characteristics of nanoparticles with their interactions with biological entities may provide critical information for nanomedicinal applications. In this work, we have presented the systematic synthesis of sub 50nm carbon nanoparticles (CNP) presenting neutral, anionic, and cationic surface headgroups. A subset of CNPs with ~ 10, 20, and 40nm hydrodynamic sizes are synthesized with neutral surface headgroups.
The cellular internalization of these CNPs was systematically quantified for the first time in various stages of breast cancer cells (early, late and metastatic), providing a parametric assessment of charge and size effects. Distinct activities are noticed with these systems as they interact with various stages of the cancer cells. Our results indicated that a metastatic breast cancer could be targeted with a nanosystem presenting anionic phosphate groups. On the contrary, for patients with late stage cancer, drugs could be delivered with sulfonate functionalized carbon nanoparticles with higher probability of intracellular transport.
This study will facilitate a better understanding of nanoparticle-biologic interaction and the integration of this knowledge with pathophysiology would help to engineer nanomedicine with superior likelihoods to cross the endocytic “barrier” for delivering drug inside the cancerous cells.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-05-01The student, Indrajit Srivastava, accepted the attached license on 2017-04-15 at 12:14.The student, Indrajit Srivastava, submitted this Thesis for approval on 2017-04-15 at 12:25.This Thesis was approved for publication on 2017-04-26 at 10:41.DSpace SAF Submission Ingestion Package generated from Vireo submission #10779 on 2017-08-10 at 15:05:38Made available in DSpace on 2017-08-10T20:32:56Z (GMT). No. of bitstreams: 2
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Previous issue date: 2017-04-26U of I Only Restriction Lifted for Item 102762 on 2019-08-11T09:15:21Z
Next generation multi-color carbon dots: A comprehensive understanding of their photophysical properties and subsequent use for biomedical applications
No full textAs an upcoming and emerging class of carbon-based nanomaterials, carbon dots (CDs) have garnered widespread attention amongst researchers over the past decade owing to their strong optical properties, water solubility, excellent biocompatibility, and easy synthetic procedures. These remarkable properties of CDs have resulted in utilizing them for a wide variety of biomedical application ranging from bioimaging, cell labeling, drug delivery, and sensors.
For synthesizing these CDs, multitude of different raw materials and synthetic approaches have been reported. The reported raw materials utilized range from natural products such as glucose, citric acid, etc. to laboratory-synthesized chemical. Furthermore, the synthetic approaches used vary from laser ablation, hydrothermal reactions, microwave treatment, pyrolysis, etc. However, in most of those studies, the photoluminescence (PL) of CDs is broad, with emission raging between blue and green region, and show excitation-dependent emission characteristics indicating that these CDs are produced in complex mixtures. To separate this, a variety of separation techniques including high performance liquid chromatography (HPLC), polyacrylamide gel electrophoresis (PAGE) were the yield is very less. Furthermore, the quantum yield (QY) of these CDs are low with no clear understanding of their PL properties limit their applications in biological applications such as in vivo imaging.
In this thesis, I attempted to perform a comprehensive understanding of the photophysical properties of CDs so that they could be tuned to produce brighter, high QY emitting which could be eventually used in wide variety of biological applications including in vivo animal imaging. Towards this goal, I first performed an in-depth understanding of the PL mechanisms of CDs both at ensemble level as well as single-particle level and found it’s PL to be correlated with their surface defects as well as abundance of oxygen-rich groups on the nanoscale surface of CDs. Subsequently, extrapolating this information, I fabricated CDs with high quantum yield and mutli-color CDs so that they could be used for multiscale in-vivo imaging. Additionally, I synthesized CDs having switchable PL which can switch off-switch on their PL by an external trigger such as surface passivation, UV light or hypoxia. I also attempted to study its interaction with enzymes: studying their biodegradation patterns in presence of human digestive enzymes, proteins: examining the protein corona formation with varying surface chemistry using an on-chip electrical monitoring setup, and oligonucleotides: utilizing them to deliver intracellular cargo and monitoring of biological events. Overall, I believe that this thesis provides a comprehensive understanding , a of the photophysical phenomenon of these CDs so that it would allow any researchers to fabricate them in an application-specific manner as well as knowing the likely mechanism of their complete degradation in living systems could pave a faster route for their applications in a clinically relevant setup.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2022-05-01The student, Indrajit Srivastava, accepted the attached license on 2020-04-27 at 17:31.The student, Indrajit Srivastava, submitted this Dissertation for approval on 2020-04-27 at 17:48.This Dissertation was approved for publication on 2020-05-05 at 16:52.DSpace SAF Submission Ingestion Package generated from Vireo submission #15092 on 2020-08-25 at 17:41:20Made available in DSpace on 2020-08-27T00:50:05Z (GMT). No. of bitstreams: 2
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Previous issue date: 2020-05-05Embargo set by: Seth Robbins for item 115896
Lift date: 2022-08-27T00:50:22Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 115896
Lift date: 2022-08-27T00:51:40Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemAuthor requested closed access (OA after 2yrs) in Vireo ETD systemLimite
The role of land administration domain model and spatial data infrastructure in improving ease of doing business in Indonesia
No full textLand management has four functions that are interlinkage to each other: land tenure, land valuation, land use planning and land development. These functions are the foundation of Indonesia's new strategy for improving its Ease Of Doing Business (EODB), directly in dealing with construction permits and registering property. Ideally, each permit includes Rights, Restrictions, and Responsibilities (RRRs) from land management functions. However, in a decentralization, it is difficult to manage RRRs sourced from different activities and managed by multiple data custodians. Our study applies the conceptual data modeling of spatial planning information in the revision of ISO 19152 on the Land Administration Domain Model (LADM) to ensure the interoperability of RRRs information. This paper is focus on how to establish interoperability of land information and disseminate to enable economic actors in doing complex tasks such as issuing business license and registering properties.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.GIS TechnologieGeo Informatio
Spectres of journalism
No full textThe report discussed the spectres of journalism.Bachelor of Communication Studie
National perspectives of COVID-19: case of Sri Lanka
No full textCOVID-19 pandemic has given insights into the systemic risks of a hazard, demonstrating the potency of biological hazards to not only render one sector dysfunctional but also fail the entire system. The grave and devastating impacts of the current COVID-19 call for the need to assess the state of global and national preparedness for future pandemics. This chapter provides an outline of Sri Lanka's response to the COVID-19 pandemic while delving into the current status and gaps concerning preparedness for pandemics in the country. The analysis is aimed at providing key recommendations for policymakers to improve national-level preparedness for anticipated pandemic threats. This chapter has drawn on a review of secondary literature and primary data gathered through in-depth interviews conducted with key informants in the disaster management and public health sectors in the country. Findings show that while preparedness planning for biological hazards is predominantly a responsibility of the health sector in the country, there is a pressing need to strengthen such preparedness through a unified legal framework and system of governance that allow for the transfer of relevant expertise, infrastructure, and lessons learned from previous hazards contexts to situations of pandemics; the incorporation of pandemic preparedness into national-level DRR efforts and subnational-level DRR planning; intensifying national focus on building economic and social resilience; emulating a multisectoral approach, enhancing private sector participation, and establishing a national framework to foster preparedness for parallel hazards
4d open spatial information infrastructure: Participatory urban plan monitoring in indonesian cities
No full textAn urban plan contains a set of agreements from all stakeholders that may directly impact livelihood. However, many cities show a ‘plan and forget’ behavior by not monitoring and evaluating their urban plans. While local citizens are often excluded after the urban plan is enacted. Gibbs (2016) warned of the risk of this behavior by saying, “local communities are given the impression that the risk is being managed, when in fact it is not.” Therefore, as the affected party, local citizens should be included in the development of the plan and the monitoring, evaluating, and reporting of urban plan implementation. However, in reality, a collaboration between authorities and local citizens in monitoring land development is rare. In some cases, cities do not share urban plans with society. This situation motivates this research by developing a framework to make urban plans interoperable and accessible to the broader community by determining four particular objectives: (i) to identify what type and specification of spatial data are required to support participatory monitoring of the implementation of the urban plan; (ii) to design information interoperability of land-use plans for participatory urban plan monitoring; (iii) to construct spatial data governance that allows two-way information flows between stakeholders in participatory urban plan monitoring; and (iv) to develop a prototype for PUPM that enables two-way information flows and multidimensional spatial representation to support participatory urban plan monitoring. This study was built upon the four functions of land management: land tenure, land valuation, land-use planning, and land development. Information interoperability is essential for allowing interaction between these functions, particularly in PUPM. This study supports the revision of the ISO 19152 on the Land Administration Domain Model (LADM) by developing Spatial Plan Information Package (SP Information Package) for accommodating information from land-use planning and land development planning. In recent years, cities have adopted the digital twin concept to represent physical urban objects by exploiting 3D spatial information for improving the spatial thinking of all stakeholders. A common interest of urban planners in using an updated 3D spatial information for Rights, Restrictions, and Responsibilities (RRRs) was depicted for further analysis. Therefore, this study proposes the digital triplets concept for representing the legal situation of the land in four-dimensional representation (3D geometry with temporal aspect managed as an attribute). This thesis presents the development of a prototype using 4D spatial representation for supporting PUPM. The prototype enables two-way information flows between urban planners and citizens to enable the co-production of urban information. This study also proposes user-centered and data governance aspects in a holistic approach to implementing the proposed standard and technology, particularly for sharing RRRs with all stakeholders through an Open Spatial Information Infrastructure. The result of this study is implemented with actual urban plan data in the two biggest Indonesian cities: Jakarta and Bandung City. A usability test was conducted to assess the implementation of participatory urban plan monitoring using RRRs. The result shows that our approach can accommodate RRRs from the spatial planning process, providing a complete overview of the legal situation of the land or urban space to all stakeholders to monitor the implementation of urban plans to support the Sustainable Development Goals: ‘plan and progress’.A+BE | Architecture and the Built Environment (2021)GIS Technologi
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