43,309 research outputs found
NO.DI - No Discrimination
No full textNo.DI. è un progetto europeo realizzato dalla Regione Umbria in partenariato con Regione Marche, A.C.S.I.M., Cidis Onlus, Fondazione Caritas Senigallia Onlus, Free Woman Onlus, Gruppo Umana Solidarietà G. Puletti, On the road Onlus, Università degli studi di Urbino Carlo Bò e supportato da una rete territoriale composta da Enti Pubblici Locali (Province Comuni), Associazioni, Cooperative. Destinatari degli interventi sono gli operatori pubblici e del terzo settore che operano sui temi dell'immigrazione, integrazione, antidiscriminazione. Destinatari finali degli interventi sono i cittadini dei paesi terzi regolarmente soggiornanti sul territorio nazionale.
Finalità e obiettivi
NO.DI intende promuovere l'inserimento di politiche di prevenzione e contrasto alle discriminazioni etnico - razziali e multiple nelle azioni di governo delle amministrazioni delle regioni coinvolte e negli interventi di enti del Terzo Settore, sindacati, organizzazioni datoriali, forze dell'ordine, funzionali alla costituzione di Sistemi di rete regionali Antidiscriminazioni.
Percorso formativo di aggiornamento
il percorso formativo di aggiornamento previsto dal progetto (per il quale è stata richiesta la consulenza scientifica e l'intervento da parte dell'ACSIM alle dott.ssa FERMANI, MATTUCCI e SANTONI dell'Università di Macerata) ha quale obiettivo la diffusione di una conoscenza approfondita delle tipologie di discriminazione (diretta/indiretta/istituzionale/razziale/di genere/multipla) e degli ambiti della discriminazione (mass media, vita pubblica, servizio pubblico, lavoro, casa, tempo libero, scuola, servizi finanziari, forze dell'ordine, salute, trasporto pubblico). Il percorso di aggiornamento insisterà in particolare sull'approfondimento della normativa nazionale ed europea in materia di discriminazioni e sulla presentazione degli strumenti giuridici e processuali di tutela che la stessa normativa mette a disposizione per l'implementazione delle azioni di contrasto, con particolare riferimento al funzionamento e alle attività dell'Ufficio Nazionale Antidiscriminazioni Razziali (UNAR). Le lezioni saranno supportate dalla presentazione di casi studio e riferimenti pratici rispetto agli ambiti di intervento dei corsisti. Al termine delle lezioni i corsisti avranno maturato competenze teorico pratiche utili alla prevenzione di atteggiamenti ed atti discriminatori, all'individuazione e alla rimozione degli elementi discriminatori, all'informazione e al supporto delle vittime di discriminazione
Editorial: Bullying and cyberbullying: their nature and impact on psychological wellbeing
No full textStructure/funcion studies on type 1 ribosome inactivating proteins.
No full textRibosome inactivating proteins (RIPs) are toxins, which depurinate major RNA inhibiting
protein synthesis1. The cleaved N-glycosidic bond corresponds to a specific adenine located in the
sarcin/ricin loop, highly conserved in rRNAs from different species and essential for interaction with
elongation factors. RIPs depurinate other polynucleotides as RNAs from different sources, DNA,
poly(A), and even poly(ADP-ribosyl)ated proteins2. This action may lead to cell death by apoptosis
or necrosis depending upon the level of damage. The three-dimensional structure of three type 1
RIPs, dianthin 303, bouganin and lychnin4, has been solved in the crystallographic research unit of
Bologna. Their adenine polynucleotide glycosylase activity was also determined together with other
known RIPs: PAP-R, momordin I, ricin A chain and saporin-S6. Saporin-S6 releases the highest
number of adenine molecules from rat ribosomes, and poly(A), while its efficiency is similar to
dianthin 30, bouganin and PAP-R on herring sperm DNA. Measurements of the protein synthesis
inhibitory activity confirmed that saporin-S6 is the most active. The overall structure of the three
studied proteins is similar to the other considered RIPs and the typical RIP fold is conserved. The
superimposition of the Ca atoms highlights some differences in the N-terminal and C-terminal
domains. Detailed structural and potential electrostatic analyses indicates that the efficiency of
saporin-S6 on various polynucleotides may be ascribed to a negative electrostatic surface potential at
the active site and several exposed positively charged residues in the region around that site. These
two conditions, not present at the same time in others examined RIPs, may guarantee to saporin-S6
an efficient interaction with the substrates, characterized by a negatively charged backbone, and an
efficient catalysis.
1. Endo Y, Tsurugi K (1987). J. Biol. Chem., 262:8128-8130.
2. Barbieri L, Brigotti M, Perocco P, Carnicelli D, Ciani M, Mercatali L, Stirpe F (2003). FEBS Lett., 538:178-182.
3. Fermani S, Falini G, Ripamonti A, Polito L, Stirpe F, Bolognesi A. (2005) J Struct Biol., 149:204-212.
4. Fermani S, Tosi G, Farini V, Polito L, Falini G, Ripamonti A, Roveri N, Barbieri L, Chambery A., Bolognesi A
(2008) Proteins: Struct. Func. Bioinf., submitted
Il pathos nella filosofia antica
No full textIl volume raccoglie cinque studi a cura di G. Cornelli; S. Gastaldi; C. Natali e C. Viano, G. Mingucci, M. Ianne sulla nozione di pathos nell'ambito del pensiero antico
Evolution of the G+C content frontier in the rat cytomegalovirus genome
No full textWithin the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%. A region of extremely low G+C content (33.8%) is found in the 5 kb immediately to the right of the frontier, in which there are no predicted coding sequences. To the right of position 147501, the G+C content rises and predicted coding sequences reappear. However, these genes are much shorter (average 848bp, 50% G+C) than those in the left two-thirds of the genome (average 1462bp, 70% G+C). Whole genome alignment of several viruses indicates that the initial ultra-low G+C region appeared in the common ancestor of the genera Cytomegalovirus and Muromegalovirus, and that the lowering of G+C in the right third has been a subsequent process in the lineage leading to RCMV. The left two-thirds of RCMV has stop codon occurrences at 67.5% of their expected level, based on a modified Markov chain model of stop codon distribution, and the corresponding figure for the right third is 78%. Therefore, despite heavy mutation pressure, selective constraint has operated in the right third of the RCMV genome to maintain a degree of gene length unusual for such low G+C sequences
Virtual Place Identity. La percezione dell’autoefficacia negli educatori in formazione durante l’emergenza Covid-19
No full textStructure and morphology of synthetic magnesium calcite
No full textThe X-ray crystal structure refinements of two synthetic calcite single crystals containing 3.1 and 5.7 mol% magnesium were carried out. The structure of the second crystal was also refined at -80°C. No significant structural difference from biogenic magnesium calcite was found. Magnesium within the crystals of calcite forms a solid solution over the compositional range investigated. The principal axes of vibration ellipsoids at -80°C resemble very closely those of calcite suggesting that the large thermal parameters in magnesium calcite reflect increased thermal vibrations more than positional disorder. The crystals of magnesium calcite express new rhombohedral faces due to the interaction of magnesium with growing crystals. The role of magnesium in the morphology of single crystal and globular aggregates of magnesium calcite is discussed in view of its possible relevance in both biomineralization and crystal growth
Cholesterol derivatives make large part of the lipids from epidermal molts of the desert-adapted Gila monster lizard (Heloderma suspectum)
No full textIn order to understand the cutaneous water loss in the desert-adapted and venomous lizard Heloderma suspectum, the microscopic structure and lipid composition of epidermal molts have been examined using microscopic, spectroscopic and chemical analysis techniques. The molt is formed by a variably thick, superficial beta-layer, an extensive mesos-region and few alpha-cells in its lowermost layers. The beta-layer contains most corneous beta proteins while the mesos-region is much richer in lipids. The proteins in the mesos-region are more unstructured than those located in the beta-layer. Most interestingly, among other lipids, high contents of cholesteryl-β-glucoside and cholesteryl sulfate were detected, molecules absent or present in traces in other species of squamates. These cholesterol derivatives may be involved in the stabilization and compaction of the mesos-region, but present a limited permeability to water movements. The modest resistance to cutaneous water-loss of this species is compensated by adopting other physiological strategies to limit thermal damage and water transpiration as previous eco-physiological studies have indicated. The increase of steroid derivatives may also be implicated in the heat shock response, influencing the relative behavior in this desert-adapted lizard
New material perspective for waste seashells by covalent functionalization
No full textSeashells are a calcium-carbonate-based material that can be converted into valuable advanced functional materials. Seashells are also a waste material from aquaculture. They are produced in millions of tonnes per year and represent an environmental issue. They uniquely contain an intraskeletal organic matrix rich in carboxylate groups that so far has not been exploited or has been even removed, when they were used as calcium carbonate substitutes. The intraskeletal organic matrix allows for a so far never reported covalent functionalization. Such a process strengthens the surface functionalization with respect to adsorption and, most importantly, opens up the possibility for the functionalization of the biogenic calcium carbonate with a wide variety of molecules by means of organic chemistry reactions. As a proof of concept, powdered waste oyster shells were covalently functionalized with a fluorescent probe. The impact of this research can be terrific in the valorization of CaCO3 from biogenic wastes providing advanced functional products tailored for individual applications. Moreover, its consequences on the environment and society will epitomize a perfect example of a circular economy
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