3,874 research outputs found
“We Must be Able to Show How Science is Beneficial to Society”
No full textBen L. Feringa Interviewed on the Occasion of SCS Spring Meeting
Prelog Lecture 2005
No full textOn Monday, November 7, 2005, the rector Prof. Dr. K. Osterwalder presented the Prelog Medal 2005 to Prof. Dr. Ben L. Feringa, University of Groningen, The Netherlands. The title of the lecture that followed was \u27In Control of Chirality, from Asymmetric Catalysis to Nanomachines\u27
Spatiotemporal Control Over Circadian Rhythms With Light
No full textABSTRACT Circadian rhythms are endogenous biological oscillators that synchronize internal physiological processes and behaviors with external environmental changes, sustaining homeostasis and health. Disruption of circadian rhythms leads to numerous diseases, including cardiovascular and metabolic diseases, cancer, diabetes, and neurological disorders. Despite the potential to restore healthy rhythms in the organism, pharmacological chronotherapy lacks spatial and temporal resolution. Addressing this challenge, chrono‐photopharmacology, the approach that employs small molecules with light‐controlled activity, enables the modulation of circadian rhythms when and where needed. Two approaches—relying on irreversible and reversible drug activation—have been proposed for this purpose. These methodologies are based on photoremovable protecting groups and photoswitches, respectively. Designing photoresponsive bioactive molecules requires meticulous structural optimization to obtain the desired chemical and photophysical properties, and the design principles, detailed guidelines and challenges are summarized here. In this review, we also analyze all the known circadian modulators responsive to light and dissect the rationale following their construction and application to control circadian biology from the protein level to living organisms. Finally, we present the strength of a reversible approach in allowing the modulation of the circadian period and the phase
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