820 research outputs found
GUEST ARTIST LECTURE-RECITAL ADRIENNE E. WILEY-LIPPOLDT, piano Friday, January 26, 1990 6:00 p.m. in the Shepherd School Recital Hall
No full textRecorded by Ultimo Productions.PROGRAM: Four-voiced fugue for left hand / Frederich Kalkbrenner -- Teaching Literature: Left's turn only / Robert Vandall -- Nocturne / Robert Vandall -- One can tango / Hilda Hubert Tanner -- Prelude in A major / Frédéric Chopin, Felix De Cola -- Prelude in C minor / Frédéric Chopin, Felix De Cola -- Prelude in B minor / Frédéric Chopin, John W Schaum -- Solfeggietto / Carl Philipp Emanuel Bach, A. R. Parsons -- Technical Studies: Study For The Left Hand / Curtis Smith -- Twenty-five studies, book II, Op. 89, nos. 15, 18, 24 / Hermann Berens -- Etude, Op. 92, No. 5 / Meritz Moszkowsky -- Etude, Op. 10, No. 3 / Frédéric Chopin, Leopold Godowsky -- Standard Literature: Prelude and nocturne, Op. 9, Nos. 1 and 2 / Alexander Scriabin -- Chaconne in D minor for the left hand alone / Johann Sebastian Bach, Johannes Brahm
Correction to: Bican, R., Christensen, C., Fallieras, K., Sagester, G., O’Rourke, S., Byars, M., & Tanner, K. (2021). Rapid Implementation of Telerehabilitation for Pediatric Patients During COVID-19
No full textCorrection to: Bican, R., Christensen, C., Fallieras, K., Sagester, G., O’Rourke, S., Byars, M., & Tanner, K. (2021). Rapid Implementation of Telerehabilitation for Pediatric Patients During COVID-19. International Journal of Telerehabilitation, 13(1). https://doi.org/10.5195/ijt.2021.6371
The affiliation for each author was incorrectly stated as: Physical Medicine & Rehabilitation, Children’s Minnesota, Minneapolis, Minnesota, USA
The correct affiliation for each author is: Clinical Therapies, Nationwide Children’s Hospital, Columbus, Ohio, USA
The metadata for the original article has been corrected
Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells.
No full textObjective: Deletion of the mitochondrial gene p66Shc protects from endothelial dysfunction and atherosclerotic plaque formation in mice fed a high-fat diet. However, the molecular mechanisms underlying this beneficial effect have not yet been delineated. The present study was designed to elucidate the proatherogenic mechanisms by which p66Shc mediates oxidized low-density lipoprotein (oxLDL) uptake by the endothelium, a critical step in plaque formation.
Methods and Results: Incubation of human aortic endothelial cells with oxLDL led to phosphorylation of p66Shc at Ser36. Inhibition of lectin-like oxLDL receptor-1 prevented p66Shc phosphorylation, confirming that this effect is mediated by lectin-like oxLDL receptor-1. OxLDL also increased phosphorylation of protein kinase C β2 (PKCβ2) at both Thr641 and Ser660, as well as c-Jun N-terminal kinase (JNK). Furthermore, inhibition of PKCβ2 prevented the activation of JNK, suggesting that PKCβ2 is upstream of JNK. Finally, p66Shc silencing blunted oxLDL-induced O2−. production, underscoring the critical role of p66Shc in oxLDL-induced oxidative stress in endothelial cells.
Conclusion: In this study we provide the molecular mechanisms mediating the previously observed atherogenic properties of p66Shc. Taken together, our data set the stage for the design of novel therapeutic tools to retard atherogenesis through the inhibition of p66Shc
Profile interview: Book author - Journalism ethics at work
No full textInterview with Stephen Tanner, Gail Phillips, Chris Smyth & Suellen Tapsall. Authors of Journalism Ethics at Work, Pearson Education, Frenchs Forest, NSW, 2005
Molecular epidemiology of animal and human brucellosis in Mongolia
No full textIn Mongolia, human brucellosis became an issue in the 1960s. During the 1980s, thanks to livestock vaccination, human incidence was reduced to less than 1 case per 100,000 populations. In the 1990s, human brucellosis re-emerged due to the breakdown of government run disease surveillance and control programs and the lack of resources in the veterinary and medical sectors. Since 2000, the government of Mongolia has been implementing a mass brucellosis vaccination which extended until 2021. The brucellosis mass vaccination was not able to interrupt transmission from livestock to humans. This requires trace-back investigation of brucellosis using molecular epidemiological methods for medical and veterinary sectors in Mongolia. There is still a lack of understanding of the most important livestock-human brucellosis transmission, and no molecular epidemiological data is available for analysis of the current situation.
The principal objective of this PhD thesis was to provide the national brucellosis control program with evidence-based decision making to enhance its effectiveness. The evidences were provided through employing different research methods implemented in the selected areas of the study.
A simultaneous assessment of humans and livestock was conducted to help better understand the disease situation and understand access of the rural people to brucellosis diagnosis and treatment. Another study was carried out sampling of infected livestock and brucellosis patients from a hospital to identify the main Brucella spp. using bacteriological and molecular methods. Brucella melitensis turns out to be the main strain dominantly circulating in the country. The main reservoir host for B. melitensis is the sheep from which the strains spill over to goats and humans. A vaccine cool chain assessment of the national livestock vaccination checked the quality of brucellosis vaccines. Overall these assessments strive to improve the quality of the national brucellosis control program
The Old English Bede: Transmission and Textual History in Anglo-Saxon Manuscripts
No full textAn unknown author translated the Old English version of Bede’s Ecclesiastical History (OEB) around the ninth century. Previous research focused on the text’s authorship, specifically on Mercian linguistic features in its earliest manuscript, rather than the reception and transmission of its manuscripts (Miller, 1890; Whitelock, 1962; Kuhn, 1972). This thesis considers the OEB’s reception and transmission as evident in its copyists’ scribal performances. Conservative and innovative textual variants are identified for the OEB, and scribal behaviour categorised according to the framework devised by Benskin and Laing (1981) in their study of Middle English scribes. A detailed linguistic comparison of OEB witnesses combined with a close examination of the physical manuscripts reveals the working methods of scribes involved in their production. The manuscripts examined are:
Oxford, Bodleian Library Tanner 10 (T)
Oxford, Corpus Christi College 279B (O)
Cambridge, Corpus Christi College 41 (B)
Cambridge, University Library Kk.3.18 (Ca)
Each chapter analyses a particular scribal performance. O’s scribe created a Mischsprache text, combining Mercian and West-Saxon forms, yet conflicting views of what constituted a good text are revealed by O’s producers’ extensive textual corrections. Relict forms in B demonstrate that its exemplar was illegible in places and that the scribe was forced to make several textual repairs. Ca has long been considered a direct copy of O, however my detailed comparison of the two manuscripts reveals that this cannot be the case. Finally, some previously unnoticed and unpublished drypoint annotations to O’s text are presented and explored in the context of other Anglo-Saxon scratched material.
This thesis shows the benefits of examining the OEB from a scribal viewpoint, identifying common modes of scribal behaviour across the medieval period. It proposes a set of features belonging to the original translation, some of which hint at an earlier date of composition than previously supposed
Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease
No full textOBJECTIVE: The interplay between oxidative stress and inflammation is crucial in the pathogenesis of atherosclerosis. The adaptor protein p66Shc is implicated in atherogenesis and oxidative stress related responses in animal models of diseases. However, its role in humans remains to be defined. In this study, we hypothesized that expression of p66Shc increases in peripheral blood monocytes of patients affected by acute coronary syndromes (ACS). METHODS: Male subjects aged 59±4 (mean±SD) years admitted for cardiac catheterization were subdivided in three groups: (a) no local stenosis for the control group, (b) at least one stenosis ≥75% in either left, circumflex or right coronary artery for the coronary artery disease (CAD) group or (c) ST-elevation/non-ST-elevation myocardial infarction for the ACS group. Monocytes were isolated from whole blood and p66Shc RNA levels were determined by quantitative real time PCR. RESULTS: p66Shc RNA levels were increased in ACS patients as compared to CAD (p=0.007) and controls (p=0.0249). Furthermore, malondialdehyde (MDA) and C-reactive protein (CRP) were increased in plasma of ACS patients. Levels of MDA correlated positively to p66Shc (r=0.376, p=0.01). Our data demonstrate increased p66Shc levels in monocytes of ACS but not CAD patients. CONCLUSION: This study suggests an involvement of p66Shc in the transition of a stable CAD to an ACS patient. p66Shc was associated with states of increased oxidative stress. Further work is needed to understand whether p66Shc may represent a possible pharmacological target or whether it represents an interesting novel biomarker
Young women's use of a microbicide surrogate: The complex influence of relationship characteristics and perceived male partners' evaluations
No full textThis is the post-print version of the article. The official published version can be found at the link below.Currently in clinical trials, vaginal microbicides are proposed as a female-initiated method of sexually transmitted infection prevention. Much of microbicide acceptability research has been conducted outside of the United States and frequently without consideration of the social interaction between sex partners, ignoring the complex gender and power structures often inherent in young women’s (heterosexual) relationships. Accordingly, the purpose of this study was to build on existing microbicide research by exploring the role of male partners and relationship characteristics on young women’s use of a microbicide surrogate, an inert vaginal moisturizer (VM), in a large city in the United States. Individual semi-structured interviews were conducted with 40 young women (18–23 years old; 85% African American; 47.5% mothers) following use of the VM during coital events for a 4 week period. Overall, the results indicated that relationship dynamics and perceptions of male partners influenced VM evaluation. These two factors suggest that relationship context will need to be considered in the promotion of vaginal microbicides. The findings offer insights into how future acceptability and use of microbicides will be influenced by gendered power dynamics. The results also underscore the importance of incorporating men into microbicide promotion efforts while encouraging a dialogue that focuses attention on power inequities that can exist in heterosexual relationships. Detailed understanding of these issues is essential for successful microbicide acceptability, social marketing, education, and use.This study was funded by a grant from National Institutes of Health (NIHU19AI 31494) as well as research awards to the first author: Friends of the Kinsey Institute Research Grant Award, Indiana University’s School of HPER Graduate Student Grant-in-Aid of Research Award, William L. Yarber Sexual Health Fellowship, and the Indiana University Graduate and Professional Student Organization Research Grant
Genotyping of Cryptosporidium spp. isolated from human stool samples in Switzerland
No full textIn a study to estimate the frequency of Cryptosporidium infections in Switzerland, stool samples from patients found to be positive for Cryptosporidium spp. by modified Ziehl-Neelson staining and fluorescence microscopy were used for genotyping experiments. With 9 of 12 samples, DNA extraction and subsequent genotyping was successful. All Cryptosporidium-isolates belonged to the bovine genotype. In one stool sample, two strains of Cryptosporidium were demonstrated, suggesting a mixed infection. In comparison with reference strains from calves, one of the isolates showed a full sequence identity and the other a similarity of 97.5%. The fact that only bovine genotypes were detected suggests, that cryptosporidiosis must primarily be considered as a zoonotic disease in Switzerland. This is in contrast to other countries, where the human genotype of C. parvum was shown to dominate the epidemiological situation. The results of our study are supported by the previous finding, that two of the analysed strains originated from patients who used to consume raw milk or raw cream, a known risk factor for cryptosporidiosis
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