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Immunoreactive ACTH, immunoreactive human chorionic somatomammotrophin (HCS) and 11-OH steroids plasma levels in normal and pathological pregnancies.
No full textPlasma immunoreactive ACTH (I.R.ACTH), immunoreactive human chorionic somatomammotrophin (I.R.HCS) and 11-OH steroids levels were measured during normal and pathological pregnancies. Plasma I.R.ACTH levels were found to be above normal during pregnancy, with a slight decrease near term. This observation correlates well with the recent description of human chorionic corticotrophin (HCC), i.e. a factor of placental origin possessing a high biological adrenocorticotrophic activity and presenting partial immunological cross-reaction with human ACTH. The 11-OH steroids levels, as measured by a fluorimetric method, increased regularly during pregnancy but, unlike ACTH, reached their highest value near term, I.R.HCS increased progressively until term when a slight decrease was observed. In pathological pregnancies, I.R.ACTH levels behaved like other placental hormones. On the contrary, 11-OH steroids levels remained generally unmodified. Treatment with high doses of prednisolone caused no inhibition of the plasma I.R.ACTH and of plasma 11-OH steroids levels. These data suggest placental autonomy of the secretion of HCC and low adrenal responsiveness to endogenous ACTH variations throughout pregnancy
[Changes in pancreatic and plasmatic immuno-reactive insulin (IRI) in rats treated with human chorionic somato-mammotropin (HCS). Preliminary note].
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DIFFERENTIAL-EFFECTS OF INSULIN AND HYPERGLYCEMIA ON INTRACELLULAR GLUCOSE DISPOSITION IN HUMANS
No full text[Glucose metabolism in rat epididymal adipose tissue in vitro, in presence of human chorionic somato-mammotropin (HCS). Preliminary note].
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Note sulla produzione degli ormoni steroidei ovarici nella pre e nella post-menopausa
No full textThis paper is a review of up to date published work on the changes in ovarian production of steroids that take place in connection with menopause. The major groups of hormonal steroids (estrogens, progestagens and androgens) are considered one by one. The importance of these variations is briefly discussed
The double effect of human chorionic somatomammotropin (HCS) and pregnancy on lipogenesis and on lipolysis in the isolated rat epididymal fat pad and fat pad cells.
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Glucose and insulin tolerance throughout the menstrual cycle
No full textOn the basis of the behaviour during menstrual cycle of the pituitary hormones plasma levels, the Authors have studied during the different periods of the cycle (follicular, ovulatory and luteal) the effects of OGTT and ITT's on the plasma levels of Glucose, insulin, HGH and Cortisol. Significantly lower levels of IRI, HGH and Cortisol were found in follicular phase compared to ovulatory period and luteal phase except for Cortisol in luteal phase. A slightly higher glucose tolerance was found in follicular phase as well as a reduced hypoglicemia under insulin load. Reduced HGH response to ITT was found in follicular phase as well as a reduced Cortisol response compared to the results observed in ovulatory and luteal phase. These data sustain the concept that hormonal variations occurring in an ovulatory cycle are also capable of modifying the woman's body response to various stimuli such as OGTT and ITT
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