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Bone-marrow derived CXCR4-positive tissue-committed stem cell recruitment in human right ventricular remodeling
No full textHum Pathol. 2010 Nov;41(11):1566-76.
Bone-marrow-derived CXCR4-positive tissue-committed stem cell recruitment in human right ventricular remodeling.
Castellani C, Padalino M, China P, Fedrigo M, Frescura C, Milanesi O, Stellin G, Thiene G, Angelini A.
Source
Department of Medical-Diagnostic Sciences and Special Therapies, University of Padua, Medical School, 35121 Padua, Italy.
Abstract
The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular remodeling in a model of pressure volume overload leading to right ventricle hypertrophy. Eleven specimens with hypoplastic left heart syndrome were evaluated and compared with 6 normal hearts from subjects matched for age and weight. All underwent Norwood procedure with the right ventricle becoming a systemic one, with pressure and volume overload leading to right ventricle remodeling. Transmural cardiac tissue samples from the right ventricle were analyzed by immunohistochemistry and morphometry. This is the first study to demonstrate that c-Kit-positive progenitor cells and tissue-committed stem cells (CXCR4+/CD45-) are higher in children with systemic right ventricle remodeling. We also show that the localization of cardiac progenitor and recruited CXCR4+ stem cells in the myocardium is site specific in hearts with right ventricle hypertrophy. These cells are mainly scattered in the interstitium of the epicardial layer. In contrast, myocyte proliferation is not a key process in right ventricular hypertrophy. Induced by the overexpression of SDF-1α by the myocardium, CXCR4 cell mobilization resembles SDF-1 homing factor distribution, showing transmural enhanced expression from the endocardium toward the epicardium. The study provides evidences of the site-specific epicardial localization of stem cells in a model of pressure/volume overload and suggests that the epicardium acts as a permissive niche in normal and pathologic conditions.
Copyright © 2010 Elsevier Inc. All rights reserved.
PMID:
20621330
[PubMed - indexed for MEDLINE
APPROCCIO ORALE NEL TRATTAMENTO CHIRURGICO DI ALCUNE MALATTIE DELLE VIE AERIFERE SUPERIORI DEL CAVALLO
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Improved processing of selective NMR spectra of biopolymers by separation of noise and signal subspaces through singular-value decomposition
No full textLinear prediction and Prony's method for 2D nuclear magnetic resonance spectral parameter estimation
No full textCollecting duct carcinoma of kidney producing alpha-fetoprotein
Full text linkA case of a collecting duct carcinoma (CDC) of the kidney alpha-fetoprotein producing is reported. Serum elevation of alpha-fetoprotein (AFP) is a common marker for hepatocellular carcinoma, although some extrahepatic carcinomas, also of the kidney, with elevated AFP levels have also been reported in the literature.
CASE REPORT:
A 62-year-old man with a collecting duct carcinoma of the kidney presenting as a mediastinal mass and supra-clavicular lymph node enlargement, and with a serum alpha-fetoprotein (AFP) level of 102.8 microg/L.
RESULTS AND CONCLUSIONS:
CDC of the kidney is associated with an aggressive course and extremely poor prognosis. There are no standard treatment regimens, and neither immunotherapy nor chemotherapy has been found to be effective. In the present case, nephrectomy followed by a chemotherapeutic association of carboplatin and gemcitabine gave promising results, with lessening of the patient's symptoms
Use of autocorrelation-like function to improve the performance of linear-prediction parameter estimators
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