8,320 research outputs found
Optimal Vaccination in a SIRS Epidemic Model
No full textFederico S, Ferrari G, Torrente M-L. Optimal Vaccination in a SIRS Epidemic Model. Center for Mathematical Economics Working Papers. Vol 667. Bielefeld: Center for Mathematical Economics; 2022.We propose and solve an optimal vaccination problem within a deterministic compart-mental model of SIRS type: the immunized population can become susceptible again, e.g. because of a not complete immunization power of the vaccine. A social planner thus aims at reducing the number of susceptible individuals via a vaccination campaign, while minimizing the social and economic costs related to the infectious disease. As a theoretical contribution, we provide a technical non-smooth verification theorem, guaranteeing that a semiconcave viscosity solution to the Hamilton-Jacobi-Bellman equation identifies with the minimal cost function, provided that the colosed-loop equation admits a solution. Coditions under which the closed-loop equation is well-posed are then derived by borrowing results from the theory of Regular Lagrangian Flows. From the applied point of view, we provide a numerical implementation of the model in a case study with quadrativ instantaneous costs. Amongst other conclusions, we observe that in the long-run the optimal vaccination policy is able to keep the percentage of infected to zero, at least when the natural reproduction number and the reinfection rate are small.MSC2010 subject classification: 93C15, 49K15, 49L25, 92D3
El derecho a la salud en Argentina
No full textEl capítulo analiza la evolución constitucional y jurisprudencial del Derecho a la Salud en la Argentina (prohibición de regresión arbitraria, tratamiento eficaz y medios alternativos, condiciones de existencia digna, derechos reproductivos, VIH, medicamentos, discapacidad, obligaciones de efectores privados, y vacunación y autonomía familiar).Fil: Aldao, Martin Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Derecho. Instituto de Investigaciones Jurídicas y Sociales "Dr. Ambrosio L. Gioja"; ArgentinaFil: Clérico, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitat Erlangen-Nuremberg; AlemaniaFil: de Fazio, Federico Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Derecho. Instituto de Investigaciones Jurídicas y Sociales "Dr. Ambrosio L. Gioja"; Argentina. Universidad Nacional de La Plata; Argentin
Casimir Delavigne e Marino Faliero
No full textIl Marino Faliero di Casimir Delavigne, fonte del melodramma omonimo di Donizetti, sullo sfondo del teatro francese della prima metà dell'Ottocent
Il curricolo in prospettiva interculturale. Tra istruzione ed educazione e formazione iniziale e in servizio di insegnanti e dirigenti scolastici
No full textIl saggio si distingue nei seguenti paragrafi: 1. Il Master del DESU UNIMORE; 1.1 La reciprocità tra fattori sociali, culturali e psicologici (di tipo cognitivo e affettivo): conoscere per progettare in prospettiva pedagogica; 1.2 Dalla multicultura, all’intercultura e alla transcultura; 1.3 Per una visione e un’azione complesse e plurali, di sistema e integrate: tra
compiti e rete, strumenti e strategie; 1.4 La(le) famiglia(e) come osservatorio e progetto della migrazione, la lingua
e il lavoro come mezzi di integrazione e inclusione culturale e sociale; 1.5 Il curricolo in prospettiva interculturale; 2. La didattica della lingua italiana; 3. La didattica della matematica; 3.1 Per un quadro di riferimento nella cornice del pensiero Occidentale; 3.2 Trasposizione culturale e consapevolezza culturale in didattica della matematica come processo di emancipazione; 3.3 Un riscontro a conclusione; 4. La crescita culturale e professionale tra formazione iniziale e in servizio; Bibliografia. Il contributo è il risultato di un lavoro comune. Gli autori hanno condiviso l’impianto dell’intero
articolo e la bibliografia. Laura Cerrocchi è autrice dei §§ 1 e 4; Federico Zannoni è autore del § 2;
Alessandro Ramploud è autore del § 3.
Laura Cerrocchi è stata Direttrice/Coordinatrice del Master Fami nella edizione della sede del Dipartimento di Educazione e Scienze Umane dell'Università degli Studi di Modena e Reggio Emilia mentre Federico Zannoni e Alessandro Ramploud ne sono stati tutor
Fresh fruit and vegetables: a world of multiple interactions : the case of the Buenos Aires Central Wholesale Market (BACWM)
No full textThis research explores ethnographically the everyday social interactions between the ‘users’ of a particular marketplace, the Buenos Aires Central Wholesale Market (BACWM). The ‘users’ of this marketplace are the social actors who work there everyday, and who bring and buy fresh produce. These ´users´ are the ´makers´ of the BACWM since, through their everyday practices, interactions and interpretations and knowledge, they socially construct this hub of distribution
A Laboratory for Mathematics
No full textMacchine matematiche; dalla storia alla scuola is a book by Maria Grazia Bartolini Bussi and Michela Maschietto that provides a description of the reconstruction of many
historical machines for drawing, and their impact on the history of mathematics. Underlying the book’s thesis are ideas about
education and developments in neuroscience. Laura Tedeschini Lalli discussed the book and the educational experiments and
their goals with author Maria Grazia Bartolini Bussi
Melanoma progression is reduced by the ciliated protozoan toxin climacostol: results from in vitro and in vivo studies
No full textMelanoma progression is reduced by the ciliated protozoan toxin climacostol: results from in vitro and in vivo studies
Authorship:
Federico Buonanno1, Cristiana Perrotta2, Laura Guerra3, Simona Picchietti3, Anna Maria Fausto3, Enrico Marcantoni4, Simone Giorgi4, Claudio Ortenzi1, Davide Cervia2,3
1Laboratory of Protistology and Biology Education, University of Macerata, 62100 Macerata, Italy
2 Department of Biomedical and Clinical Sciences “Luigi Sacco” (DIBIC), Università di Milano, via G.B. Grassi 74, 20157 Milano, Italy
3 Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), Università della Tuscia, via S. Camillo de Lellis snc, 01100 Viterbo, Italy
4School of Sciences and Technologies, Section of Chemistry, University of Camerino, 62032 Camerino, Macerata, Italy
Text:
Melanoma diagnoses have risen sharply over past decades, and despite new lines of therapy have been introduced the need for additional drugs is urgent. Previous findings from our group demonstrated that climacostol, an alkyl resorcinol produced by the ciliated protozoan Climacostomum virens, decreases the viability of five different mammalian cancer cell lines, while it was devoid of effects on endothelial cells. In order to expand these data and due to the availability of the synthetic toxin, we have further analysed different tumoral and non-tumoral cell lines, observing that viability of human and rodent tumoral cells was negatively affected by climacostol with higher potency when compared to non-tumoral cells. We then focused on the B16-F10 mouse melanoma cells, where climacostol caused a concentration-dependent reduction of viability with an EC50 of 6.3 μg/ml, and an Emax of 30 μg/ml. Flow cytometry analyses indicated that cell proliferation was effectively inhibited by climacostol, with a significant increase of apoptotic cells.The data collected prompted us to investigate the effects of climacostol on in vivo melanoma progression using a B16-F10 allograft transplantation tumor model. The results indicate that climacostol decreased tumour weight and increased the content of apoptotic cells, suggesting that the toxin may be considered for the design of cytotoxic and pro-apoptotic new drugs for melanoma therapy
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