1,721,622 research outputs found
Our second genome and the impact on metabolic disorders: why gut microbiome is an important player in diabetes and associated abnormalities
No full textGut microbiome and microbial metabolites: a new system affecting metabolic disorders
No full textIntroduction The gut microbiome is emerging as an important player in the field of metabolic disorders. Materials and methods Currently, several studies are ongoing to determine whether the effect of gut microbiome on obesity, type 2 diabetes, non-alcoholic fatty liver disease, and other metabolic diseases is determined by singular species or rather by a functional role of bacterial metabolism at higher taxonomical level. Deciphering if a single or more species are responsible for metabolic traits or rather microbial metabolic pathways are responsible for effects on host metabolism may help to identify appropriate dietary interventions to support microbial functions according to the prevalent host disease. Furthermore, the combination of metagenomics and metabolomics-based signature might be applied in the future to improve the risk prediction in healthy subjects. Conclusion In this review, I will summarize the current findings regarding the role of gut microbiome and metabolites in metabolic disorders to argue whether the current achievements may be translated into clinical practice
Effect of ezetimibe on cholesterol absorption and lipoprotein composition in diabetes and metabolic syndrome
No full textEzetimibe exerts multiple favorable effects on the lipoprotein profile and reduces some inflammatory markers. Decreasing cholesterol synthesis with statin treatment can cause a compensatory increase in cholesterol absorption that reduces the efficacy of statin therapy, whereas addition of a cholesterol absorption inhibitor can improve outcomes. Recent evidence suggests a beneficial effect on atherosclerosis. In patients with diabetes, the effect of insulin resistance on low-density lipoprotein metabolism combined with the effect of hyperglycemia on cholesterol absorption may further diminish the favorable effects of statins. Further analysis is needed also to determine whether the stronger effects of ezetimibe seen in patients with diabetes are a consequence of an interaction of the drug with specific mechanisms
The strange case of G972R IRS-1 variant and diabetes. Do type 1 and type 2 diabetes share common genes?
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MicroRNA manipulation to boost endothelial regeneration: Are we ready for the next steps?
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L'edilizia sociale di fronte all'immigrazione a Modena: politiche abitative e domanda potenziale (o inevasa)(DEP, Materiali di discussione, n. 651)
No full textVenous distal bypass should be considered as the gold standard to finally attempt limb salvage in patients with severe critical limb ischemia and diabetic foot, or under dialysis
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