1,356,248 research outputs found
Bleached Montipora and Favia Coral
No full textA close-up of bleached Montipora and partially bleached Favia coral on a reef.https://digitalcommons.usf.edu/ogden2_images/1013/thumbnail.jp
Template for assessing bone quality and methods of use thereof
No full textUnited States Patent Application 20080119719
Kind Code A1
Ascenzi; Maria-Grazia ; et al. May 22, 2008
TEMPLATES FOR ASSESSING BONE QUALITY AND METHODS OF USE THEREOF
Abstract
The present invention relates to the preparation and use of novel bone templates that can be prepared using a
comprehensive approach to observing microstructural features of bone, including trabecular thickness and
trabecular density. These features are assessed in regions of interest in a bone (e.g., proximal femur, distal
femur, wrist, spine, etc.) as observed using digital radiographic techniques or clinical imaging, such as Dual
Energy X-ray Absorptiometry (DEXA) and computed tomography (CT) scanners. The microstructural
features are presented in the form of data based on scanning results and are also assessed and/or organized in
terms of age, gender, race, pathology, clinical history, and other patient population parameters. The template
can be used to assess bone quality, predict the likelihood of bone fracture, and evaluate prosthesis design and
placement, based on an image of a corresponding subject bone, e.g. the bone of a patient.
Inventors: Ascenzi; Maria-Grazia; (Santa Monica, CA) ; Favia; Angela; (Bari, IT)
Assignee: The Regents of the University of California
Oakland
CA
Class at Publication: 600/410; 435/4
International Class: C12Q 1/00 20060101 C12Q001/00; A61B 5/05 20060101
A61B005/0
La ricostruzione degli edifici A e B / The reconstruction of the Buildings A and B, in P. Favia, R. Giuliani (eds.), Gli edifici nella parte meridionale del sito
No full text
NON INVASIVE MODERATE LOADING IN VIVO AND OSTEOARTHRITIS DEVELOPMENT
No full textMechanical loading is known to modify joint structure through a mechano-adaptative response and to increase proinflammatory cytokines, as IL-1β, modulating VEGF secretion by condrocytes1. VEGF is a potent angiogenic factor, also detectable in later stages of OA, able to increase matrix MMPs playing an important role in the development of OA2. The aim of this study is to evaluate “in vivo” changes of bone and cartilage leading to OA by means of nonsurgical intermittent moderate loading. Forty day-old mice was randomly divided into two groups of six animals each: sedentary and exercised. The exercised group was subjected to a treadmill running at 12m/min, two times a week for four weeks. The sedentary group did not undergo any physical training and was left free to walk inside the cages. After the sacrifice the femur heads were removed and processed for paraffin embedding. On 5μm coronal sections, safranine-O staining and immunostaining for IL-1 β, MMP-13 and VEGF was performed to evaluate: articular cartilage and subchondral bone trabeculae thickness; chondrocytes number/mm2; chondrocytes volume; % cell number expressing VEGF, IL-1β and MMP-13 in articular cartilage and bone. Significant increase of chondrocytes volume, VEGF and MMP-13 expression in cartilage was detected. These data seem indicate that our non-invasive experimental model could induce early alterations in articular cartilage only, confirming chondrocytes to play a central role in the pathogenesis of OA. Other alterations, such as articular cartilage cracking and thickening and sub-chondral bone sclerosis, would appear later
Intervertebral disc calcification in childhood: Case report and review of relevant literature
No full textThe authors report the case of a 10-year-old girl with intervertebral disc calcifications from the levels C6/C7 to Th1/Th2, presenting with a herniated calcified intervertebral disc at the C7/Th1 level, causing spinal cord compression with subsequent progressive paresis and sensory loss of her left leg. After anterior cervical discectomy and fusion the neurological deficits completely resolved within 2 weeks. It can be concluded that calcification of an intervertebral disc is a rare syndrome in childhood, causing progressive neurological deficit only in a few reported cases. Although the treatment of choice is conservative, surgery is required in patients who develop progressive neurological deficit
Ricerche archeologiche a Canne della Battaglia (BT)
No full textImpostazione di nuove ricerche archeologiche a Canne della Battaglia (BT). La campagna di ricerche si è prefissa di revisionare tutta la documentazione relativa agli scavi pregressi, di effettuare ricognizioni nei magazzini dell'Antiquarium per verificare la consistenza dei reperti da sottoporre a studio, di effettuare prime indagini geofisiche nell'area della Cittadella e nel suo suburbio, di impiantare primi saggi di scavo in punti strategici per la conoscenza della storia dell'insediamento (area dell'episcopio-saggio I; area dell'abitato, a Sud (saggio II) e a Nord (saggio III) del 'Decumano'; area prospiciente le mura (saggio IV)
White sponge naevus with minimal clinical and histological changes: report of three cases
No full textNaringenin as a novel inhibitor of Two-Pore Channel 2 controlling the angiogenic process in vitro and in vivo
No full textTwo Pore Channels (TPCs) are an emerging family of intracellular channels,
expressed on acidic compartments, which mediate calcium signaling evoked by
NAADP. In particular, we demonstrated that TPC2 isoform has a main role in angiogenesis
(Favia et al. PNAS 2014 Nov 4;111(44):E4706-15). TPC2 inhibition is emerging
as a key therapeutic step in a range of important pathological conditions including
the progression and metastatic potential of cancer, Parkinson’s disease, and Ebola
virus infection. We introduce naringenin, a natural flavonoid, as a novel TPC2 inhibitor
as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis
vacuoles lacking endogenous TPCs. In view of the control exerted by TPC2
on intracellular calcium signaling and angiogenesis, we demonstrate that naringenin
dampens intracellular calcium responses of human endothelial cells stimulated with
VEGF, histamine or NAADP-AM, but not with ATP or Angiopoietin-1. The ability of
naringenin to impair TPC2-dependent biological activities was further explored in
an established in vivo model in which VEGF-containing matrigel plugs implanted in
mice failed to be vascularized in the presence of naringenin. Our present data suggest
that naringenin inhibition of TPC2 activity and the observed inhibition of angiogenic
response to VEGF are linked by impaired intracellular calcium signaling. The relationship
we describe here between naringenin and TPC2 is therefore likely to have
wider implications in systems other than the vascular system, thus representing a
novel tool for experimental, and possibly even clinical, research purposes
PHACES Syndrome: Diode Laser Photocoagulation of Intraoral Haemangiomas in Six Young Patients
No full textINTRODUCTION: The acronym PHACES describes the association of posterior fossa malformations, facial hemangiomas, arterial anomalies (cardiovascular or cerebrovascular), coarctation of the aorta and cardiac defects, eye abnormalities, and sternal or ventral defects. In this study we report on 6 patients affected by the PHACES syndrome and showing 34 intraoral hemangiomas (IH), treated by diode laser photocoagulation (DLP).
CASE PRESENTATION: IH appeared as red-bluish soft masses, smooth or lobulated, from a few millimetre to several centimetres in size, covered by intact mucosa and blanching on pressure. IHs were treated by DLP with 320μm fibres at a wavelength of 800±10nm. The diode laser techniques applied were: Transmucosal DLP (DLTP), a no-contact technique in which laser energy is delivered by a flexible optic quartz fiber, which is kept 2-3mm apart from the lesion, and Intralesional DLP (DLIP), in which the fibre is introduced into the lesion through a transmucosal access. DLTP was used for 20 flat, superficial IHs and, after a variable number of laser sessions (average=3) depending on the size of the lesion, 65% completely regressed, while in the remaining 35% shrinkage of the lesion was achieved with minor and few complications. The remaining 14 deep/multi-lobulated IHs were treated by DLIP, resulting in complete regression of 79% of them.
CONCLUSIONS: DLP techniques are an effective and minimally invasive procedure for IH in patients with PHACES, in consideration of the multiple lesions to treat, of the necessity of multiple interventions and the higher compliance of the patients
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