1,721,056 research outputs found
Addressing new therapeutic strategies using models
Full text linkA disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, to establish the pathophysiology of a disease, and to test potential therapeutic approaches.
Models have been long used to study several diseases, including cardiovascular, oncologic, metabolic, infectious, and neurological diseases, among others. Animals or cells displaying pathological processes observed in human or animal diseases have been used as models. Moreover, mathematical models are also of great importance to disease modeling. Animal models offer the unique opportunity to investigate the function of genes and pathways and the in vivo effects of drugs, bridging the gap between basic science and the treatment of diseases. The selection of a suitable model system is a crucial step in research design. For disease modeling to be meaningful, a relevant cellular or genetic phenotype must be observed. Without the use of models, both research and clinical practice worldwide would be vastly different today.
This Special Issue aims to publish original research works or reviews with models of disease, highlighting their importance to search for new therapeutic strategies
Addressing the importance of animal models for breast cancer research
Full text linkBreast cancer is one of the most frequent cancers among women worldwide. According to the World Health Organization, in the year 2020, breast cancer was diagnosed in approximately 2.3 million women and victimized 685.00 women. The increasing number of breast cancer cases leads to the need to search for more
effective diagnostic and therapeutic approaches for breast cancer care. Animal models have been used since early times to understand several diseases. In vivo studies are essential to improve and discover new strategies to prevent and treat cancer more effectively, improving patients’ lifespan and quality of life. This presentation intends to describe the importance of animal models for breast cancer research, focusing on rodent models
Addressing the importance of animal models for breast cancer Research
No full textFaustino-Rocha AI. 2023. Addressing the importance of animal models for breast cancer Research. 13th World Congress on Breast Cancer, 02 de maio (online
2nd International Forum on Animal Science and Veterinary Medicine 2023 (ASVMFORUM2023)
No full text2nd International Forum on Animal Science and Veterinary Medicine (ASVMFORUM2023
Chemical carcinogens: an overview.
No full textFaustino-Rocha AI. 2023. Chemical carcinogens: an overview. 8th Edition of Global Conference on Pharmaceutics and Novel Drug Delivery Systems, 13 a 14 de mai
Are animal models important? An overview of animal models of cancer
No full textFaustino-Rocha AI. 2023. Are animal models important? An overview of animal models of cancer. International Conference on Veterinary Science, 28 a 29 de agosto
Spontaneous Zymbal’s gland tumor in a 25-week old Wistar male rat: a case report
No full textThis work describes a spontaneous Zymbal's gland tumor
Animal models of skin cancer: the example of a chemically- induced rat model
No full textFaustino-Rocha AI. 2023. Animal models of skin cancer: the example of a chemically- induced rat model. 3rd Global Virtual Congress on Cancer research & Drug Development, 15 de maio
Prostate cancer
Full text linkThe prostate is the largest accessory gland of the male reproductive tract. Together with seminal vesicles and bulbourethral glands, the prostate is responsible for the production of an alkaline fluid that forms part of the seminal fluid. The prostate of men over 40 years of age is commonly affected by several pathologies, such as benign prostate hyperplasia and cancer.
Prostate cancer is one of the most frequent cancers among the male population worldwide. According to the World Health Organization (WHO), in the year 2020, prostate cancer affected approximately 1.41 million men and was responsible for the death of 375,304 of them. Prostate cancer development is associated with several risk factors including older age, black ethnicity, a family history of the disease, an increased body mass index, and obesity. The risk of prostate cancer development may be reduced through the consumption of a healthy diet full of fruits and vegetables, practice of physical exercise, and maintenance of a healthy weight.
Despite several approaches being available for prostate cancer treatment, the number of prostate cancer deaths is continuously increasing, which emphasizes the need to search for new methods for precocious diagnosis and more effective treatment. Animal models including rodents have greatly contributed to the study of biopathology and the prevention and treatment of prostate cancer.
This Special Issue entitled “Prostate Cancer II” aims to publish original research works and reviews concerning the diagnosis, treatment, and prognosis of prostate cancer, highlighting new advances in this field
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