1,721,077 research outputs found
A national trainee advisory network: a proposal
No full textTrainees should have a well-defined and consistent communication conduit to the authorities involved with their training. It is important that trainees are involved in the evolution of structured training programmes and for training authorities to receive feedback from individuals in each specialty. This paper proposes a structure for trainee representation on regional and national training authorities to facilitate an advisory network
Fluarix quadrivalent vaccine for influenza
No full textInfluenza A and B infections cause significant morbidity and mortality. Over the past 30 years, two main influenza B strains have been circulating globally. The trivalent influenza vaccine used in the last 25 years contains one B strain, with approximately 31% of B strain disease coverage over the last 10 years. Fluarix quadrivalent vaccine, containing two A and two B strains, combines the components of two existing trivalent vaccines to prevent this mismatch. This review gives an overview of the published data about Fluarix quadrivalent vaccines, showing an immunogenicity and safety profile of the vaccine comparable with the two licensed trivalent vaccines containing the same strains, but with no evidence for efficacy in the literature. Future vaccines aim for a universal influenza vaccine that will give a long-lasting protection against all influenza strains<br/
New therapies for treating infections in infants and children
No full textInfections remain important causes of mortality and morbidity in infants and children. The first part of this review examines evidence for the use of novel or experimental treatments in serious bacterial infections. New therapeutic strategies to treat specific viral and fungal infections are also considered. Finally, we examine novel strategies to prevent infections in the community and in the hospital setting. New treatments for tropical infections are out of the scope of this review
Pathophysiology of meningococcal meningitis and septicaemia
No full textNeisseria meningitidis is remarkable for the diversity of interactions that the bacterium has with the human host, ranging from asymptomatic nasopharyngeal colonisation affecting virtually all members of the population; through focal infections of the meninges, joints, or eye; to the devastating and often fatal syndrome of meningococcal septic shock and purpura fulminans
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