2 research outputs found
Epidemiology of congenital heart disease among pediatric patients in Northwest, Saudi Arabia
Get PDFBackgroundCongenital heart defect (CHD) is considered one of the commonest major birth defects, causing children’s morbidity and mortality.AimsTo define the frequency and epidemiology of congenital heart disease among children in Tabuk, Saudi Arabia.Methods This was a retrospective observational study based on the medical hearts. The study population consisted of pediatric patients with confirmed CHD, who were referred to the pediatric cardiology clinic at the King Salman Armed Forces Hospital, Tabuk, Saudi Arabia between January 2015 and June 2019. Of patients with CHD, those with patent ducts arteriosus (PDA) and persistent foramen oval spontaneously resolved during the first four weeks of life were excluded.Results A total of 1,647 pediatric patients were referred to the pediatric cardiology clinic. Of these, 851 were confirmed to have CHD. The diagnosis was made most frequently during the neonatal period. The following three were most frequently observed (in the order of): Ventricular septal defect (VSD: 42 per cent), atrial septal defect (ASD: 32.6 per cent), PDA (16.2 per cent). Down syndrome (DS) was the most frequent underlying condition. Approximately two-thirds of cases were managed conservatively.ConclusionWe demonstrated the characteristics of children’s CHD in this referral center. The data may be important to further make health-policy-making in this area
Efficacy of tranexamic acid administration in traumatic brain injury patients: A review
Get PDFBackgroundAnti-fibrinolytic medications decrease traumatic intracranial haemorrhage (ICH). Tranexamic acid (TXA) is an anti-fibrinolytic, which recently has shown effectiveness in management of traumatic haemorrhage.AimsTo summarize the randomized control trials (RCTs) that evaluate the efficacy of tranexamic acid administration in traumatic brain injury (TBI) patients.Methods An electronic literature review, including PubMed, Google Scholar, and EBSCO that examining RCTs, observational, and experimental studies which study the efficacy of TXA administration in (TBI) patients.ResultsThe current review included 7 randomized studies reported the efficacy of TXA in management of TBI. TXA limit secondary brain injury by preventing the expansion of ICH. Administration of TXA exhibited a tendency to decrease head trauma-related mortality.ConclusionTXA significantly lower the risk of ICU expansion m and prevent brain injury related deaths
