2 research outputs found
Efficacy and safety of oral GnRh antagonists in patients with uterine fibroids: A systematic review
No full textObjective: This review aimed to assess the efficacy and safety of GnRH antagonists in patients with symptomatic uterine fibroids.Data sources: A literature search was performed on PubMed, Web of Science, Embase, Cochrane, and clinicaltrials.gov using the MeSH and Emtree terms Leiomyoma and Gonadotropin-Releasing Hormone. Study selection: All clinical trials that provided efficacy and safety data in clinical terms (i.e., reduction in menstrual bleeding and discomfort, changes in the size of leiomyoma and uterine volume, etc.) were included. We excluded all preclinical studies, case reports, meta-analyses, review articles, and clinical studies irrelevant to the study question.Data extraction and synthesis: Two authors extracted data from 9 clinical studies. The extracted data included the study\u27s characteristics, participants\u27 baseline characteristics, treatment drugs, efficacy measures, and toxicity.Conclusion: Among oral GnRH antagonists, relugolix, elagolix, and linzagolix were safe in patients with uterine fibroids. These drugs, alone, and in combination with estradiol/norethindrone acetate (E2/NETA), showed significantly better efficacy than placebo in improving bleeding, discomfort, uterine/leiomyoma sizes, and quality of life in premenopausal patients with symptomatic uterine fibroids. However, more randomized double blind multicenter clinical trials are needed to confirm these results and to see long-term benefits
THE INCIDENCE OF ALCOHOL USE DISORDERS DURING THE COVID-19 PANDEMIC
No full textBackground: The COVID-19 pandemic has introduced a myriad of challenges to healthcare systems and public health policies
across the globe. Individuals with alcohol use disorders are at peaked risk due to mental, socio-demographic, and economic factors
leading to hindered mental health service access, misinformation and adherence.
Methods: Keywords including “alcohol use”, “death”, “hand sanitizer", "overdose" and "COVID-19" were used to obtain 8
media reports for case analysis. A review of 34 manually extracted records were also conducted using PubMed, MEDLINE, Scopus,
and the Embase database with no time and language restrictions.
Results: A total of 2,517 individuals with alcohol overdose across the United States, India, Canada, and Iran were presented.
The majority of cases were male, ages 21-65. Common contributors were linked to socio-economic changes, disruption to mental
health services, and physical isolation.
Conclusion: While original studies are essential to evaluate the etiologies of alcohol use and misuse during pandemics, the
dissemination of misinformation must be curbed by directing vulnerable individuals towards accurate information and access to
mental health services
