27 research outputs found
Erratum To ‘Response To Early Coenzyme Q10 Supplementation Is Not Sustained In Coq10 Deficiency Caused By Coq2 Mutation’ [Pediatric Neurology 88 (2018) 71–74](S0887899418303795)(10.1016/J.Pediatrneurol.2018.07.008)
No full textThe publisher regrets to inform that the affiliation of the author Fehime Eroglu, Fatih Ozaltin, Rezan Topaloglu and Ali Düzova has been incorrectly published earlier. The publisher would like to apologise for any inconvenience caused. The affiliations should be corrected as follows: Fehime K. Eroglu, MD a , Fatih Ozaltin, MD a,b , Nazli Gönç, MD c , Hülya Nalçacıoğlu, MD d , Z. Birsin Özçakar, MD e , Dilek Yalnızoğlu, MD f , Şafak Güçer, MD g , Diclehan Orhan, MD g , Fatma Tuba Eminoğlu, MD h , Rahşan Göçmen, MD i , Ayfer Alikaşifoğlu, MD c , Rezan Topaloğlu, MD a , Ali Düzova, MD a, * a Division of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey b Nephrogenetics Laboratory, Division of Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey c Division of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey d Division of Pediatric Nephrology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey e Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara, Turkey f Division of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey g Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey h Division of Pediatric Metabolism, Ankara University Faculty of Medicine, Ankara, Turkey i Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey © 2018 Elsevier Inc.Scopu
Origin, petrogenesis and geodynamic implications of the early Eocene Altinpinar adakitic andesites in the eastern Sakarya Zone, northeastern Turkey
No full textEarly Cenozoic magmatism in the eastern Sakarya Zone (NE Turkey) provides an important constraint on the regional tectono-magmatic evolution of the region. Early Eocene syn-collisional adakitic rocks are observed as small stocks with outcropping areas commonly less than 10 km(2). This study presents petrography, whole-rock geochemistry and Sr-Nd-Pb isotope data, as well as in-situ Ar-40/Ar-39 age constraints on one of these adakitic andesites in the Altinpinar area of Gumushane, and discusses source region, petrological processes and geodynamic setting prevailed during their genesis. Andesites commonly show microlitic porphyric and vitrophyric porphyric textures, and include significant amounts of mafic microgranular enclaves (MMEs). Plagioclase, hornblende, Fe-Ti oxides and minor pyroxene are the main mineral phases. In-situ Ar-40-Ar-39 amphibole dating constrains the cooling age of andesites into a time span from 52.8 +/- 1.3-48.8 +/- 1.9 Ma. Andesites are medium to high-K calc-alkaline and display most of the signatures typical of those of the adakites. They are characterized by moderate MgO (1.7-4.1 wt%), low Y (9-14 ppm), Yb (0.9-1.5 ppm), and HREE and high Sr (325-964 ppm) contents, and high Sr/Y (36-76) ratios. Sr-87/Sr-86((t)) (0.704948-0.705100) and Nd-143/Nd-144((t)) (0.512588-0.512628) ratios are in the isotopic range of the adakites. All these geochemical and isotopic data suggest that the parental magma of adakitic andesites has been produced by partial melting of oceanic basalts under amphibole-eclogite facies conditions during the breakoff of the northern Neotethyan oceanic slab.Gumushane University Sci-entific Research Projects Coordination Department (GuBAP) [18, F5114.02.02]This study was financially supported by Gumushane University Sci-entific Research Projects Coordination Department (GuBAP) under the project number 18.F5114.02.02. The author sincerely thanks Enver Akaryal, Emre Aydncakr and Cem Yucel for their support during the field and laboratory studies. Many thanks also go to Alison Halton (The Open University, UK) for performing Ar-Ar dating and Frank C. Ramos (New Mexico State University, USA) for the isotope analyses. I would also like to thank Abdurrahman Dokuz for discussions on adakites and regional geology. The author would like to thank reviewers for their contribution and suggestions, which improved the quality of the manuscript. I am also grateful to Handling Editor Dewashish Upadhyay and Editor-in-Chief Astrid Holzheid for their helpful feedback and timely processing of the paper.WOS:0006946675000012-s2.0-8511042787
Robot-assisted laparoscopic transperitoneal infrarenal lymphadenectomy in patients with locally advanced cervical cancer by single docking: Do we need a backup procedure?
No full textAr-40-Ar-39 age, petrography and geochemistry of the Yoncayolu Metamorphic Rocks (NE Turkey): Subduction-related metamorphism under greenschist fades conditions
No full textThe Yoncayolu Metamorphic Rocks (YMR), exposed in the Sakarya zone (Erzincan, NE Turkey), consists mainly of greenschist rocks which are chlorite schists, muscovite-chlorite schists, metabasic rocks and lesser extent of pyhllites and calc-schists. All YMR are fine-grained, weakly foliated and often cut by quartz veins. The common mineral assemblage is chlorite+albite+epidote+quartz+/-clinozoisite+/-actinolite+/-opaques. Geochemically, protoliths of the YMR resemble calc-alkaline volcanic arc rocks. The YMR have high contents of large ion lithophile elements (LILEs) and low contents of high field strength elements (HFSEs) similar to mid-ocean ridge basalt (MORB). (La/Lu)(CN) values are between 0.26 and 6.16. The REE patterns show slight or no Eu anomalies (Eu-CN/Eu* of 0.48 to 1.13), suggesting minor plagioglase fractionation. Ar-40-Ar-39 dating on plagioclases from the metabasic samples of the YMR gave ages of 100.8+/-3.4 Ma (Albian) and 94.1+/-3.3 Ma (Cenomanian), suggesting that metamorphism was related to the closure of the Neo-Tethyan Ocean. Metamorphism took place during subduction of the Neo-Tethyan Ocean between similar to 90-70 Ma. Chlorite geothermometry yielded a temperature of 320-350 degrees C and a pressure around 4 kbar. All these findings lend support for greenschist facies metamorphic conditions during the formation of the YMR.Karadeniz Technical University Scientific Research FundThis article is derived from the MSc thesis of the first author. The study was financially supported by the Karadeniz Technical University Scientific Research Fund. The authors thank WOLFGANG SIEBEL, for general improvement of the manuscript and HEINZ-GUNTER STOSCH for his editorial input. Special thanks to MEHMET ARSLAN and ARAL OKAY for constructive criticism, OMER BOZKAYA and BEKTAS UZ for reviews. Thanks also go to LANG SHI for performing the microprobe analyses at McGill University, Canada. AARON STALLARD improved the English of the manuscript.WOS:00033880570000
Breast cancer, ovarian gonadoblastoma and cervical cancer in a patient with Peutz-Jeghers Syndrome
No full textBackground Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder characterized by gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. Patients with PJS have increased risk for gastrointestinal, breast, and female genital tract cancers. Case Multiple genital tract cancers in a 34-year-old woman with PJS are described. The patient, who was admitted to our department with severe vaginal bleeding, was performed right salpingo-oophorectomy because of pure gonadoblastoma in 1996. In 2003, concomitant to cervical carcinoma, breast cancer was diagnosed. Patient underwent left modified radical mastectomy due to the invasive papillary carcinoma. The patient received six cycles combination chemotherapy and radiation therapy because of stage IIIB cervical cancer. Conclusion(s) This is the first case report presenting PJS associated with multiple genital tract tumors including ovarian gonadoblastoma in literature. The clinical significance of these tumors in PJS patients has been reviewed
Purpura fulminans as the presenting manifestation in a patient with juvenile SLE
No full textWe present a 12-year-old girl with systemic lupus erythematosus and associated antiphospholipid syndrome who developed an unusual manifestation of purpura fulminans in an accelerated fashion. The patient improved after prompt treatment with anticoagulants, aggressive immunosuppressive drugs and plasmapheresis. This is the first pediatric case of purpura fulminans due to secondary antiphospholipid syndrome of systemic lupus erythematosus. We suggest that SLE patients with lupus anticoagulant should be followed closely for similar complications
OC-7 Cresentic glomerulonephritis (CGN) in childhood; classification of aetiology and clinicopathological importance of cd163 positive (M2) macrophages
No full textExpression of Bcl-2 and Ki-67 in tamoxifen-associated endometrial polyps: Comparison with postmenopausal polyps
No full textBackground: The aim of this study was to evaluate the expression of Bcl-2 and Ki-67 in tamoxifen (TAM)-associated endometrial polyps and postmenopausal polyps. Material and Methods: For this purpose, a retrospective analysis of paraffin-embedded specimens was carried out. Polyps of 20 postmenopausal and 14 TAM-treated patients, 11 simple endometrial hyperplasia, 10 atypical complex endometrial hyperplasia and 8 endometrial adenocarcinoma specimens were included in the study. Hematoxylin/eosin-stained sections were evaluated. Immunohistochemical staining was performed to investigate the expression of Bcl-2 protein and the Ki-67 proliferation index. Results: There was no statistically significant difference between the 5 groups with regard to Bcl-2 staining (p > 0.05). However, Bcl-2 expression in TAM-associated polyps was higher (86%) than in the postmenopausal control group (80%). Positive Ki-67 was highest in the endometrial adenocarcinoma specimens, followed by the atypical complex endometrial hyperplasia group (p < 0.0001). Compared to these 2 groups, Ki-67 expression was lower in TAM-associated polyps, but Ki-67 indexes were significantly higher in the TAM-associated group than in the control group (p < 0.0001). Conclusion: Since TAM-associated polyps tend to have higher proliferation indexes and Ki-67 ratios than control groups, we suggest that they are likely to have a higher malignant potential
Nature of clays in Late Cretaceous dacitic rocks in the eastern Sakarya Zone (NE Turkey): a geochemical and isotopic approach
No full textLate Cretaceous felsic rocks are common in the eastern Pontides (NE Turkey). These rocks developed as an island arc from the Jurassic to the Miocene; they also host numerous volcanogenic massive sulfide deposits. The Late Cretaceous dacites that outcrop around Zigana Mountain (Gumushane, NE Turkey) were exposed to intensive hydrothermal alteration. Widespread hydrothermal alteration of Late Cretaceous dacite in Zigana Mountain has led to the formation of well-developed clay minerals. Their main alteration products are sericite, chlorite, and carbonates (ankerite and calcite). The clay minerals identified by X-ray diffraction and differential thermal analysis include illite, chlorite, small amounts of kaolinite, and smectite. The polytype of illite is 2M(1). Illites formed as a result of hydrothermal alteration of feldspars; they are also Fe- and Mg-poor. Chlorite is characterized by decreasing Fe/(Fe+ Mg) ratio with increasing alteration grade and has a trioctahedral structure. Chlorite geothermometer calculations (100-300 degrees C) reflect the activities of hydrothermal solutions. Chlorite forms in more alkaline conditions compared with illite, as its formation is associated with the presence of carbonates. Oxygen and hydrogen stable isotope values, K-Ar dating of Mites, and textural and chemical evidence suggest that clays might have formed mainly by alteration of minerals in dacitic rocks with hydrothermal fluids of magmatic origin during the Campanian under acidic-weak alkaline conditions.Karadeniz Technical University Research Funds [2001.112.005.1]This research is a part of the PhD study of the first author. The authors thank Dr. Tayfur Kucukomeroglu from Karadeniz Technical University (Trabzon, Turkey) for XRD measurements, Karadeniz Technical University Research Funds (Project No: 2001.112.005.1) for financial support, and Dr. Yakov Kapusta for the K-Ar dating. The authors also thank Dr. Maarten A.T.M. Broekmans who improved the content of the manuscript.WOS:0005677171000012-s2.0-8509136245
Effect of IGF-1 and HGF induced bone marrow mesenchymal stem cells on focal segmental glomerulosclerosis in Sprague-Dawley rats: a pilot study
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