14 research outputs found
EVALUATION OF NEUTROPHIL TO LYMPHOCYTE RATIO AS AN INDICATOR OF PRESENCE OF CORONARY ARTERY DISEASE IN DIABETIC PATIENTS
No full textIntroduction: Cardiovascular disease (CVD) is the leading cause of death in type 2 diabetes mellitus (DM). DM is a substantial risk factor in atherosclerotic cardiovascular disease. We aimed to investigate relationship between the presence of established neutrophil to lymphocyte ratio (NLR) and coronary artery disease (CAD) in DM.
Methods: 104 diabetic patients who had coronary lesion with a diameter stenosis of at least 50% and 64 diabetic patients who had normal coronary anatomy matched with age and sex were retrospectively selected and classified CAD (+) and CAD (-) group respectively. Baseline NLR in two groups was compared.
Results: NLR was higher in CAD (+) group compared to group without CAD (-) (2.69±1.74 vs. 1.98±.85, p<0.001). C reactive protein (CRP) was higher in CAD (+) group compared to group without CAD (-) (1.71±99 vs. 1.38±.99 p=0.02). Multivariate analysis indicated CRP and NLR were an independent indicator of presence of CAD in diabetic patients (Odds ratio: 1.405, %CI: 1.035-1.908, p=0.029 and odds ratio: 1.759, %CI: 1.226-2.525, p=0.002 respectively).
Conclusion: NLR was higher in diabetic patients with angiographically proven CAD compared to those without CAD. NLR may be a useful marker to predict the presence of CAD in type 2 diabetic patients
Red cell distribution width is correlated with extensive coronary artery disease in patients with diabetes mellitus
No full textCoronary Ectasia Is Associated with Impaired Left Ventricular Myocardial Performance in Patients without Significant Coronary Artery Stenosis
No full textObjectives: To determine both ventricular functions and tissue Doppler echocardiography (TDE)-derived myocardial performance index (MPI) in patients with coronary artery ectasia (CAE). Subjects and Methods: Twenty-five patients with CAE (13 men; mean age 57 +/- 9 years) and 25 age- and sex-matched controls without CAE (8 men; mean age 54 +/- 10 years) were enrolled in the study. Left and right ventricular functions were detected using conventional echocardiography and TDE. Results: Left ventricle-lateral wall (0.61 +/- 0.17; 0.50 +/- 0.10, p = 0.02), interventricular septum (0.66 +/- 0.17; 0.52 +/- 0.10, p = 0.007) and mean MPI (0.63 +/- 0.15; 0.51 +/- 0.09, p = 0.004) were increased in the CAE group compared to the control group. Right ventricular MPI was similar in both the CAE and control groups (0.58 +/- 0.18; 0.52 +/- 0.19, p > 0.05). Conclusion: The findings show that left ventricular MPI is different in CAE patients without obstructive coronary artery disease compared to the normal control group. Also in these patients, right ventricular MPI was similar to the control group. Copyright (C) 2011 S. Karger AG, Base
Presence of Angina Pectoris Is Related to Extensive Coronary Artery Disease in Diabetic Patients
No full textBackground Due to sensorial autonomic neuropathy, the type and severity of angina pectoris in patients with diabetes mellitus (DM) may be rather different from the type and severity of angina pectoris in patients without DM. Hypothesis The aim of the study was to understand if angina pectoris is related to extensive coronary artery disease (CAD) in patients with DM. Methods The study included 530 patients with DM who underwent coronary angiography at our center in 2009 and 2010. Patients were divided into 4 groups according to type of chest pain: group 1, noncardiac chest pain or no pain; group 2, angina equivalent; group 3, atypical angina; and group 4, typical angina. All angiograms were re-evaluated and Gensini scores were calculated. Three-vessel disease was diagnosed in the presence of stenosis >50% in all 3 coronary artery systems. Results There were no statistically significant differences between the groups with regard to age, sex, systolic or diastolic blood pressures, body mass index, creatinine clearance, or lipid profile. Fasting blood glucose was significantly higher in group 4 than in group 2. Gensini scores were not statistically different between groups 1 and 2 or between groups 3 and 4; however, the scores for groups 3 and 4 were higher than the score for either group 1 or group 2. Prevalence of 3-vessel disease was significantly higher in groups 3 and 4 compared with the other groups. Conclusions The presence of angina pectoris was related to extensive CAD in patients with DM. The extent of CAD was not correlated with the type of angina (typical or atypical)
Echocardiographic assessment of right ventricular functions in healthy subjects who migrated from the sea level to a moderate altitude
No full textObjective: The aim of this study was to evaluate right ventricle (RV) functions using echocardiography in healthy subjects who migrated from the sea level to moderate altitude (1890 m). Methods: The prospective observational in this study population consisted of 33 healthy subjects (23 men; mean age 20.4 +/- 3.2 years) who migrated from the sea level to a moderate altitude (Erzurum city centre, 1890 m above sea level) for long-term stay. Subjects underwent echocardiographic evaluation within the first 48 h of exposure to the moderate altitude and at the sixth month of arrival. Conventional echocardiographic parameters such as RV sizes and areas, systolic, and diastolic functional indices [fractional area change (FAC), tricuspid flow velocities, myocardial performance index (MPI), and tricuspid annular plane systolic excursion (TAPSE)] were obtained. Systolic (S) and diastolic (E', A') velocities were acquired from the apical four-chamber view using tissue Doppler imaging. Kolmogorov-Smirnov test, student's t-test, Wilcoxon test, and chi-square test were used in this study. Results: There were no significant changes in RV size, FAC, MPI, TAPSE, inferior inspiratory vena cava collapse, tricuspid E velocity, and tricuspid annulus E' velocity. Compared with the baseline, there was a significant increase in mean pulmonary artery pressure (p=0.001); RV end systolic area (p=0.014); right atrial end diastolic area (p=0.021); tricuspid A velocity (p=0.013); tricuspid annulus S and A' velocity (p=0.031 and p=0.006, respectively); and RV free wall S, E', and A' velocity (p=0.007, p<0.001, and p=0.007 respectively) at the sixth month. Also, there was a significant decrease in tricuspid E/A ratio (1.61 +/- 0.3 vs. 1.45 +/- 0.2, p=0.038) and tricuspid annulus E'/A' ratio (1.52 +/- 0.5 vs. 1.23 +/- 0.4, p=0.002) at the sixth month. Conclusion: Our study revealed that right ventricular diastolic function was altered while the systolic function was preserved in healthy subjects who migrated from the sea level to a moderate altitude
Serum levels of γ-glutamyl transferase are associated with cardiovascular disease in obstructive sleep apnea syndrome
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Is evaluation of placenta with real-time sonoelastography during the second trimester of pregnancy an effective method for the assessment of spontaneous preterm birth risk?
No full textWOS: 000383305400020PubMed ID: 27183142Purpose: The aim of this study is to investigate the effectiveness of placental strain ratio (SR) values measured by real-time sonoelastography (SE) in the second trimester in the prediction of spontaneous preterm birth (sPTB). Methods: This study included 70 pregnant women who applied to our clinic for routine second-trimester screening. Placental SR measurements were performed with the SE method. Two different SR measurements were performed by taking two different tissues as references. The SR value measured when taking the rectus abdominis muscle as a reference was termed the muscle-to-placenta strain ratio (MPSR), while the SR value measured when taking subcutaneous tissue as a reference was termed the fat-to-placenta strain ratio (FPSR). Women whose gestational age at birth was less than 37 weeks 0 days were accepted as sPTB. The association between gestational age at birth and MPSR and FPSR was investigated. Receiver operating characteristics analysis was used to calculate the sensitivity and specificity of the elastographic outcomes. Results: There was a low-level negative correlation between MPSR and gestational age at birth (r = 0.300, P=.012) and there was a moderate-level negative correlation between FPSR and gestational age at birth (r=-0.513, P<.001). The multivariate linear regression analysis showed that the FPSR (beta=0.609, P=.002) was the significant predictor for the sPTB. Conclusions: Our data indicate that the FPSR value measured with real-time SE in the second trimester of pregnancy may be effective in the prediction of sPTB. (C) 2016 Elsevier Inc. All rights reserved
Sodium Bicarbonate Versus Isotonic Saline for the Prevention of Contrast-Induced Nephropathy in Patients With Diabetes Mellitus Undergoing Coronary Angiography and/or Intervention: A Multicenter Prospective Randomized Study
No full textIntroduction: Contrast-induced nephropathy (CIN) is a leading cause of acute renal failure and affects mortality and morbidity. Although the incidence of CIN is quite low in the general population, CIN incidence is significantly increased in patients with diabetes mellitus (DM). Introduction: Contrast-induced nephropathy (CIN) is a leading cause of acute renal failure and affects mortality and morbidity. Although the incidence of CIN is quite low in the general population, CIN incidence is significantly increased in patients with diabetes mellitus (DM). Objectives: We compared the efficacy of prophylactic use consisting of a saline infusion or a sodium bicarbonate infusion for the prevention of CIN in patients with DM. Materials and Methods: A total of 195 DM patients who had unselected renal function were randomized into 2 groups: 101 patients were assigned to saline infusion, and 94 patients were assigned to bicarbonate infusion. The primary end point was the maximum increase in the serum creatinine (SCr) level, whereas the secondary end point was the development of CIN after the procedure. Results: The maximum increase in SCr levels was significantly lower in the saline group than in the bicarbonate group: j0.03 mg/dL (IQR, j0.09 to 0.10 mg/dL) versus 0.02 mg/dL (IQR, j0.09 to 0.13 mg/dL) (P = 0.014). The rate of CIN was significantly lower in the saline group than in the bicarbonate group (5.9% vs 16%, P = 0.024). In the subset of study participants with a baseline creatinine clearance of less than 60 mL/min, the maximum increase in SCr levels was significantly lower, j0.08 mg/dL (IQR, j0.13 to j0.04 mg/dL), in the saline group than in the bicarbonate group, 0.03 mg/dL (IQR, j0.13 to 0.12 mg/dL) (P = 0.004). Conclusions: The use of prophylactic hydration with isotonic saline before coronary procedures may decrease SCr levels and reduce the incidence of CIN in patients with DM with unselected renal functions to a greater extent than sodium bicarbonate can.</p
